Parasitic infection and autoimmunity.

abstract：:Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specifi...

journal_title：Lupus

authors： Tandon A,Anupam K,Kaushal J,Gautam P,Sharma A,Bhatnagar A

更新日期：2020-12-01 00:00:00

abstract：:The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...

journal_title：Lupus

authors： Wallace DJ

更新日期：2008-02-01 00:00:00

abstract：:The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...

journal_title：Lupus

authors： Lui SL,Lam MF,Tse KC,Lo WK

更新日期：2002-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial advice against pregna...

journal_title：Lupus

authors： Schreiber K

更新日期：2016-04-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...

journal_title：Lupus

authors： Salem D,Subang R,Laplante P,Levine JS,Rauch J

更新日期：2014-10-01 00:00:00

abstract：:This study was designed to investigate whether Foxp3( +) regulatory T (Treg) cells play a role in the histopathologic changes of primary Sjögren's Syndrome (pSS) and to evaluate other factors possibly associated with Foxp3(+) Treg cells in pSS patients. The number of FoxP3-expressing T cells in peripheral blood (PB) o...

journal_title：Lupus

authors： Sarigul M,Yazisiz V,Bassorgun CI,Ulker M,Avci AB,Erbasan F,Gelen T,Gorczynski RM,Terzioglu E

更新日期：2010-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multiple organ involvement. B-lymphocyte activity plays a pivotal role in the development and course of the disease. A newly developed agent called belimumab has recently been approved to treat active, autoantibody positive SLE as an add-on to st...

journal_title：Lupus

authors： Parodis I,Axelsson M,Gunnarsson I

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...

journal_title：Lupus

authors： Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

更新日期：2004-01-01 00:00:00

abstract：:Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...

journal_title：Lupus

authors： Li M,Li J,Wang J,Li Y,Yang P

更新日期：2018-01-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：:The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...

journal_title：Lupus

authors： Catania G,Rossi E,Marmont A

更新日期：2012-05-01 00:00:00

abstract：:Eosinophilic gastroenteritis (EGE) is an uncommon disease and has rarely been reported in association with connective tissue diseases as systemic lupus erythematosus. We report a 36-year-old woman who developed recurrent episodes of abdominal pain, nausea, vomiting and melena. Complete blood counts showed elevated eos...

journal_title：Lupus

authors： Jaimes-Hernandez J,Aranda-Peirera P,Melendez-Mercado CI

更新日期：2009-04-01 00:00:00

abstract：:Poly(ADP-ribose) metabolism is altered in patients with SLE. In order to localize the defect, the levels of poly(ADP-ribose) polymerase-specific mRNA were measured from dot blots of total RNA from peripheral blood lymphocytes. In this preliminary study, eleven patients with SLE and two with antiphospholipid syndrome w...

journal_title：Lupus

authors： Lee JS,Haug BL,Sibley JT

更新日期：1994-04-01 00:00:00

abstract：:Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...

journal_title：Lupus

authors： Mulliez SM,De Keyser F,Verbist C,Vantilborgh A,Wijns W,Beukinga I,Devreese KM

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...

journal_title：Lupus

authors： Gunashekar S,Prakash M,Minz RW,Sharma A,Sharma S,Dhir V

更新日期：2018-11-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：:The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed b...

journal_title：Lupus

authors： Toloza SM,Cole DE,Gladman DD,Ibañez D,Urowitz MB

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to examine some solid tumors incidence in patients with systemic lupus erythematosus (SLE) derived from population-based cohort studies by means of meta-analysis. METHODS:Relevant electronic databases were searched for studies characterizing the associated risk of overall malig...

journal_title：Lupus

authors： Ni J,Qiu LJ,Hu LF,Cen H,Zhang M,Wen PF,Wang XS,Pan HF,Ye DQ

更新日期：2014-03-01 00:00:00

abstract：:An assessment of prevalence for systemic lupus erythematosus (SLE) has been attempted for the population of far north Queensland in Australia. This huge area has a majority Caucasian population living in a tropical environment. Roughly 10% of the population comprises people of Australian Aboriginal or Torres Strait Is...

journal_title：Lupus

authors： Bossingham D

更新日期：2003-01-01 00:00:00

abstract：:Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...

journal_title：Lupus

authors： Rattazzi M,Faggin E,Bertipaglia B,Pauletto P

更新日期：2005-01-01 00:00:00

abstract：:Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupu...

journal_title：Lupus

authors： Di Matteo A,Satulu I,Di Carlo M,Lato V,Filippucci E,Grassi W

更新日期：2017-03-01 00:00:00

abstract：:Central nervous system (CNS) involvement may occur in 20-70% of systemic lupus erythematosus (SLE) patients where neurological symptoms are overt; this is termed neuropsychiatric lupus or NPSLE. This review summarizes evidence that damage to the brain endothelium forming the blood-brain barrier (BBB) is a contributory...

journal_title：Lupus

authors： Abbott NJ,Mendonça LL,Dolman DE

更新日期：2003-01-01 00:00:00

abstract：:Leukopenia and anaemia are observed in about a fifth of all patients with systemic lupus erythematosus (SLE) and may be due either to the destruction of blood cells or their decreased production. The former may be humoral or cell-mediated or result from apoptosis of peripheral blood cells. Several observations suggest...

journal_title：Lupus

authors： Tiefenthaler M,Bacher N,Linert H,Mühlmann O,Hofer S,Sepp N,Amberger A,Geisen F,Obermoser G,Konwalinka G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...

journal_title：Lupus

authors： Zhang X,Lindwall E,Gauthier C,Lyman J,Spencer N,Alarakhia A,Fraser A,Ing S,Chen M,Webb-Detiege T,Zakem J,Davis W,Choi YS,Quinet R

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...

journal_title：Lupus

authors： Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

更新日期：2020-01-01 00:00:00

abstract：:Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...

journal_title：Lupus

authors： Zoma A

更新日期：2004-01-01 00:00:00

abstract：:Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular...

journal_title：Lupus

authors： Glesse N,Vianna P,Paim LMG,Matte MCC,Aguiar AKK,Palhano PL,Monticielo OA,Brenol CV,Xavier RM,Chies JAB

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...

journal_title：Lupus

authors： Huang Y,Chen L,Chen K,Huang F,Feng Y,Xu Z,Wang W

更新日期：2019-03-01 00:00:00