Antiphospholipid antibodies in primary Sjögren's syndrome: prevalence and clinical significance in a series of 74 patients.

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：:Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...

journal_title：Lupus

authors： Zoma A

更新日期：2004-01-01 00:00:00

abstract：:We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...

journal_title：Lupus

authors： Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

更新日期：2011-10-01 00:00:00

abstract：:In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...

journal_title：Lupus

authors： Ungprasert P,Sagar V,Crowson CS,Amin S,Makol A,Ernste FC,Osborn TG,Moder KG,Niewold TB,Maradit-Kremers H,Ramsey-Goldman R,Chowdhary VR

更新日期：2017-03-01 00:00:00

abstract：:Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...

journal_title：Lupus

authors： Piette JC

更新日期：1996-10-01 00:00:00

abstract：:Only recently Bartonella species have been recognized as important human pathogens. Cat scratch disease (CSD), caused by infection with Bartonella henselae, shows a steady increase in the number of cases throughout the world. We report a case of an 18-year-old woman with systemic lupus erythematosus (SLE) who presente...

journal_title：Lupus

authors： Gaubitz M,Herrmann M,Shahin M,Schotte H,Willeke P,Domschke W

更新日期：2001-01-01 00:00:00

abstract：:Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...

journal_title：Lupus

authors： Jarrett P,Thornley S,Scragg R

更新日期：2016-11-01 00:00:00

abstract：:We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...

journal_title：Lupus

authors： Cicarini WB,Duarte RCF,Ferreira KS,Loures CMG,Consoli RV,Neiva CLS,de Pádua PM,Nunes FFC,Alves LCV,Reis EA,Moreira CC,Guimarães TMPD,de Toledo VPCP,Carvalho MDG

更新日期：2020-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and...

journal_title：Lupus

authors： Ippolito A,Wallace DJ,Gladman D,Fortin PR,Urowitz M,Werth V,Costner M,Gordon C,Alarcón GS,Ramsey-Goldman R,Maddison P,Clarke A,Bernatsky S,Manzi S,Bae SC,Merrill JT,Ginzler E,Hanly JG,Nived O,Sturfelt G,Sanchez-Gu

更新日期：2011-03-01 00:00:00

abstract：:Cytotoxic therapy is a cornerstone for patients with severe systemic lupus erythematosus (SLE). High-dose cyclophosphamide, 200 mg/kg, can induce a complete remission without the need for stem cell rescue in patients with autoimmune illnesses. Here we report on our first four patients treated for severe SLE with this ...

journal_title：Lupus

authors： Gladstone DE,Prestrud AA,Pradhan A,Styler MJ,Topolsky DL,Crilley PA,Hoch S,Huppert A,Brodsky I

更新日期：2002-01-01 00:00:00

abstract：:This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...

journal_title：Lupus

authors： Dhillon V,Latchman D,Isenberg D

更新日期：1991-11-01 00:00:00

abstract：:The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...

journal_title：Lupus

authors： Vlachoyiannopoulos PG,Tsiakou E,Chalevelakis G,Raptis SA,Moutsopoulos HM

更新日期：1994-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...

journal_title：Lupus

authors： Nannini C,Crowson CS,Matteson EL,Moder KG

更新日期：2009-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multiple organ involvement. B-lymphocyte activity plays a pivotal role in the development and course of the disease. A newly developed agent called belimumab has recently been approved to treat active, autoantibody positive SLE as an add-on to st...

journal_title：Lupus

authors： Parodis I,Axelsson M,Gunnarsson I

更新日期：2013-04-01 00:00:00

abstract：:Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ...

journal_title：Lupus

authors： de Groot K,Gross WL

更新日期：1998-01-01 00:00:00

abstract：:Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...

journal_title：Lupus

authors： Tripodi A,Chantarangkul V,Pengo V

更新日期：2012-06-01 00:00:00

abstract：:Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...

journal_title：Lupus

authors： Su-Angka N,Khositseth A,Vilaiyuk S,Tangnararatchakit K,Prangwatanagul W

更新日期：2017-08-01 00:00:00

abstract：:Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...

journal_title：Lupus

authors： Kiani AN,Aukrust P,Ueland T,Hollan I,Barr E,Magder LS,Petri M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pregnancies in women with systemic lupus erythematosus (SLE) and lupus nephritis are considered high-risk due to high rates of maternal and fetal complications. However, there has not been a formal analysis addressing the issue of maternal deaths in these women. The aim of this study was to pe...

journal_title：Lupus

authors： Ritchie J,Smyth A,Tower C,Helbert M,Venning M,Garovic V

更新日期：2012-04-01 00:00:00

abstract：:To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...

journal_title：Lupus

authors： Appenzeller S,Li LM,Costallat LT,Cendes F

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:We compared the 1997 update of the 1982 American College of Rheumatology (ACR-97) and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria, for earlier classification of systemic lupus erythematosus (SLE) in a multiethnic urban Asian SLE population. METHODS:Patients from a retrospe...

journal_title：Lupus

authors： Low ESH,Krishnaswamy G,Thumboo J

更新日期：2019-01-01 00:00:00

abstract：:To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...

journal_title：Lupus

authors： Cavazzana I,Sala R,Bazzani C,Ceribelli A,Zane C,Cattaneo R,Tincani A,Calzavara-Pinton PG,Franceschini F

更新日期：2009-07-01 00:00:00

abstract：:This brief review is focused on those heavy metals (cadmium, gold and mercury) that have strong associations with autoimmunity. Cadmium treatment of rats and mice results in autoimmune responses that vary with species and inbred strain of animals. However, there is no solid evidence demonstrating that the renal pathol...

journal_title：Lupus

authors： Bigazzi PE

更新日期：1994-12-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...

journal_title：Lupus

authors： Donohoe S,Kingdom JC,Mackie IJ

更新日期：1999-01-01 00:00:00

abstract：:Lupus nephritis (LN) is usually associated with widespread effacement of the podocytes' foot processes leading to proteinuria. Induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via promoting podocytes' motility and kidney permeability in the glomeru...

journal_title：Lupus

authors： Cheng CC,Lee YF,Lan JL,Wu MJ,Hsieh TY,Lin NN,Wang JM,Chiu YT

更新日期：2013-05-01 00:00:00

abstract：:The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...

journal_title：Lupus

authors： Ting W,Stone MS,Racila D,Scofield RH,Sontheimer RD

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a commonly occurring condition related to systemic autoimmune disease. It is characterized histopathologically by a distinct pattern of granulomatous inflammation in the presence or absence of leukocytoclastic vasculitis. The properties of granulo...

journal_title：Lupus

authors： Terai S,Ueda-Hayakawa I,Nguyen CTH,Ly NTM,Yamazaki F,Kambe N,Son Y,Okamoto H

更新日期：2018-12-01 00:00:00

abstract：:We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...

journal_title：Lupus

authors： Koh JH,Ko HS,Lee J,Jung SM,Kwok SK,Ju JH,Park SH

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...

journal_title：Lupus

authors： Jia J,Xie J,Li H,Wei H,Li X,Hu J,Meng D,Zhang Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus er...

journal_title：Lupus

authors： Aye SM,Lim KS,Ramli NM,Tan CT

更新日期：2013-04-01 00:00:00