Abstract:
:Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ANCA testing, the incidence of diagnosis of WG has risen in the past ten years. Although the precise pathophysiology is not understood yet, there is ample evidence that ANCA, which can lead to cytotoxic reactions in the vascular texture, play a major role, possibly promoted by a dysbalance in the anti-idiotypic network. The clinical disease course is typically two-phasic, beginning with a granulomatous inflammation of the upper respiratory tract, that usually is followed by a generalized vasculitic phase, that can range from mild organ dysfuntion to life threatening multi-organ failure. Consequently, diagnostic procedures, patients' assessment and therapeutic regimens need to be individualized, adapted to stage and activity of the disease as well as standardized.
journal_name
Lupusjournal_title
Lupusauthors
de Groot K,Gross WLdoi
10.1191/096120398678920118subject
Has Abstractpub_date
1998-01-01 00:00:00pages
285-91issue
4eissn
0961-2033issn
1477-0962journal_volume
7pub_type
杂志文章,评审相关文献
LUPUS文献大全abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086267
更新日期:2008-02-01 00:00:00
abstract::Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317691372
更新日期:2017-07-01 00:00:00
abstract::We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400506
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570688
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening condition with poor prognosis in patients with antiphospholipid syndrome (APS). Pulmonary thromboendarterectomy (PTE) is the optimal surgical option for CTEPH. OBJECTIVES:This retrospective cohort study aimed to evaluate th...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318810427
更新日期:2018-12-01 00:00:00
abstract::The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300674499064
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2R antibodies in a large cohort of p...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319828521
更新日期:2019-03-01 00:00:00
abstract::A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315573853
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319861677
更新日期:2019-08-01 00:00:00
abstract::Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310382128
更新日期:2011-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089401
更新日期:2008-06-01 00:00:00
abstract::Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308097479
更新日期:2009-04-01 00:00:00
abstract::The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1006oa
更新日期:2004-01-01 00:00:00
abstract::Objectives Avascular necrosis (AVN) is one of the most common causes of organ damage in patients with systemic lupus erythematosus (SLE) and often causes serious physical disability. The aims of this study were to investigate clinical risk factors associated with symptomatic AVN and to analyze their synergistic effect...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318784648
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller-Fisher syndrome, Guillain-Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312436856
更新日期:2012-05-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120300680199024
更新日期:2000-01-01 00:00:00
abstract::The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309346505
更新日期:2010-01-01 00:00:00
abstract::HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene, which was identified as a candidate gene for SLE susceptibility in lupus mouse model. We determined these gene expressions in leukocytes from 20 SLE patients and 10 healthy controls and in renal biopsies from 29 SLE patients and 15 kidney donor...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309106699
更新日期:2009-10-01 00:00:00
abstract::In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678920262
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract::Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314558859
更新日期:2015-06-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::Concerns regarding the safety and efficacy of immunization in patients with SLE have persisted for over 60 years, despite the increased risk of infection in these patients. There are many anecdotal case reports of SLE induction or exacerbation following immunization, but overall, these events seem to be very rare. Evi...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203306069355
更新日期:2006-01-01 00:00:00
abstract::Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imagin...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317751048
更新日期:2018-04-01 00:00:00
abstract::Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The internati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313505010
更新日期:2013-10-01 00:00:00
abstract::In this study, we report the case of a Chinese patient with systemic lupus erythematosus (SLE) who developed neutropenia after treatment by olanzapine for the SLE-related psychiatric symptoms. The relationship between agranulocytosis, SLE and olanzapine is still unknown. Fcγ receptor IIIb (FcγRIIIb) is a low-affinity ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311415889
更新日期:2012-01-01 00:00:00
abstract::The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed b...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345775
更新日期:2010-01-01 00:00:00
abstract::An assessment of prevalence for systemic lupus erythematosus (SLE) has been attempted for the population of far north Queensland in Australia. This huge area has a majority Caucasian population living in a tropical environment. Roughly 10% of the population comprises people of Australian Aboriginal or Torres Strait Is...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu381xx
更新日期:2003-01-01 00:00:00
abstract::Nodular or pseudomembranous tracheobronchitis due to infection by Aspergillus species is an uncommon presentation of invasive aspergillosis. Most cases have been described in severely immunocompromised hosts. We describe the case of a 23-year-old woman, with recently diagnosed systemic lupus erythematosus, who develop...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu206cr
更新日期:2002-01-01 00:00:00