Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity.


:Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and immunosuppressive treatment, while the behavior of anti-extractable nuclear antigen (ENA) over time is less well understood. This study sought to determine the correlation between historical autoantibody tests and current testing in patients with SLE. Three hundred and two SLE patients from the ACR Reclassification of SLE (AROSE) database with both historical and current laboratory data were selected for analysis. The historical laboratory data were compared with the current autoantibody tests done at the reference laboratory and tested for agreement using percent agreement and Kappa statistic. Serologic tests included ANA, anti-dsDNA, anti-Smith, anti-ribonucleoprotein (RNP), anti-Ro, anti-La, rheumatoid factor (RF), C3 and C4. Among those historically negative for immunologic markers, a current assessment of the markers by the reference laboratory generally yielded a low percentage of additional positives (3-13%). However, 6/11 (55%) of those historically negative for ANA were positive by the reference laboratory, and the reference laboratory test also identified 20% more patients with anti-RNP and 18% more with RF. Among those historically positive for immunologic markers, the reference laboratory results were generally positive on the same laboratory test (range 57% to 97%). However, among those with a history of low C3 or C4, the current reference laboratory results indicated low C3 or C4 a low percentage of the time (18% and 39%, respectively). ANA positivity remained positive over time, in contrast to previous studies. Anti-Ro, La, RNP, Smith and anti-dsDNA antibodies had substantial agreement over time, while complement had less agreement. This variation could partially be explained by variability of the historical assays, which were done by local laboratories over varying periods of time. Variation in the results for complement, however, is more likely to be explained by response to treatment. These findings deserve consideration in the context of diagnosis and enrolment in clinical trials.






Ippolito A,Wallace DJ,Gladman D,Fortin PR,Urowitz M,Werth V,Costner M,Gordon C,Alarcón GS,Ramsey-Goldman R,Maddison P,Clarke A,Bernatsky S,Manzi S,Bae SC,Merrill JT,Ginzler E,Hanly JG,Nived O,Sturfelt G,Sanchez-Gu




Has Abstract


2011-03-01 00:00:00
















  • Pregnancy and patients with preexisting lupus nephritis: 15 years of experience at a single center in Korea.

    abstract::We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...


    pub_type: 杂志文章


    authors: Koh JH,Ko HS,Lee J,Jung SM,Kwok SK,Ju JH,Park SH

    更新日期:2015-06-01 00:00:00

  • Antiphospholipid antibodies in primary Sjögren's syndrome: prevalence and clinical significance in a series of 74 patients.

    abstract::The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...


    pub_type: 杂志文章


    authors: Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

    更新日期:2004-01-01 00:00:00

  • Correlation of asymptomatic hyperuricaemia and serum uric acid levels with arterial stiffness in women with systemic lupus erythematosus without clinically evident atherosclerotic cardiovascular disease.

    abstract::The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...


    pub_type: 杂志文章


    authors: Sabio JM,Vargas-Hitos JA,Mediavilla JD,Navarrete-Navarrete N,Zamora-Posadas M,Pérez-Vicente S,Hidalgo-Tenorio C,Díaz-Chamorro A,Jáimez L,Jiménez-Alonso J,Grupo Lupus Virgen de las Nieves.

    更新日期:2010-04-01 00:00:00

  • Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice.

    abstract::Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...


    pub_type: 杂志文章


    authors: Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

    更新日期:2009-05-01 00:00:00

  • In vitro modulation of anti-DNA secreting peripheral blood mononuclear cells of lupus patients by anti-idiotypic antibody of pooled human intravenous immune globulin.

    abstract::Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...


    pub_type: 杂志文章


    authors: Evans M,Abdou NI

    更新日期:1993-12-01 00:00:00

  • Primary antiphospholipid antibody syndrome presenting with encephalopathy, psychosis and seizures.

    abstract::Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent thrombotic events, miscarriages and thrombocytopenia with persistently positive antiphospholipid antibodies.( 1,2 ) APS may be isolated (primary APS) or associated to a connective tissue disease, most often systemic lupus erythematosus...


    pub_type: 杂志文章


    authors: Taipa R,Santos E

    更新日期:2011-11-01 00:00:00

  • Role of HLA in congenital heart block: susceptibility alleles in children.

    abstract::Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading ...


    pub_type: 杂志文章


    authors: Sirén MK,Julkunen H,Kaaja R,Ekblad H,Koskimies S

    更新日期:1999-01-01 00:00:00

  • Association between shortened telomere length and systemic lupus erythematosus: a meta-analysis.

    abstract::Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...


    pub_type: 杂志文章,meta分析


    authors: Lee YH,Jung JH,Seo YH,Kim JH,Choi SJ,Ji JD,Song GG

    更新日期:2017-03-01 00:00:00

  • Visceral leishmaniasis complicating a connective tissue disease: three case reports from Italy.

    abstract::We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...


    pub_type: 杂志文章


    authors: Castellino G,Govoni M,Lo Monaco A,Montecucco C,Colombo F,Trotta F

    更新日期:2004-01-01 00:00:00

  • Pathogenesis of the antiphospholipid antibody syndrome.

    abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...


    pub_type: 杂志文章,评审


    authors: Lockshin MD

    更新日期:1996-10-01 00:00:00

  • Analysis of JC virus DNA in NPSLE patients treated with different immunomodulatory agents.

    abstract:OBJECTIVE:The objective of this report is to assess the presence and viral load of JC polyomavirus (JCV) DNA in cerebrospinal fluid (CSF) and plasma from neuropsychiatric systemic lupus erythematosus (NPSLE) patients in comparison to controls and to investigate if different types of immunosuppressive treatments were co...


    pub_type: 杂志文章


    authors: Iacobaeus E,Hopia L,Khademi M,Lundén M,Hammarin AL,Svenungsson E,Andersson M

    更新日期:2013-03-01 00:00:00

  • Infections in infancy and the presence of antinuclear antibodies in adult life.

    abstract::There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...


    pub_type: 杂志文章


    authors: Edwards CJ,Syddall H,Goswami R,Goswami P,Dennison EM,Cooper C

    更新日期:2006-01-01 00:00:00

  • Renal transplantation for lupus nephritis: non-adherence and graft survival.

    abstract:OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...


    pub_type: 杂志文章,多中心研究


    authors: Ntatsaki E,Vassiliou VS,Velo-Garcia A,Salama AD,Isenberg DA

    更新日期:2019-04-01 00:00:00

  • High-dose immunosuppression with autologous stem cell transplantation in severe refractory systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is an immune-mediated disease that is responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide (Cy), represent a subset of patients at high risk of early de...


    pub_type: 杂志文章


    authors: Lisukov IA,Sizikova SA,Kulagin AD,Kruchkova IV,Gilevich AV,Konenkova LP,Zonova EV,Chernykh ER,Leplina OY,Sentyakova TN,Demin AA,Kozlov VA

    更新日期:2004-01-01 00:00:00

  • Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies.

    abstract::The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...


    pub_type: 杂志文章


    authors: Bengtsson AA,Sturfelt G,Truedsson L,Blomberg J,Alm G,Vallin H,Rönnblom L

    更新日期:2000-01-01 00:00:00

  • Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients.

    abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...


    pub_type: 杂志文章


    authors: Ma R,Jiang W,Li Z,Sun Y,Wei Z

    更新日期:2016-12-01 00:00:00

  • Prothrombin as cofactor for antiphospholipids.

    abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...


    pub_type: 杂志文章,评审


    authors: Galli M,Barbui T

    更新日期:1998-01-01 00:00:00

  • Antiphospholipid syndrome and the idiotypic network.

    abstract::To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...


    pub_type: 杂志文章


    authors: Bakimer R,Blank M,Kosashvilli D,Ichikawa K,Khamashta MA,Hughes GR,Koike T,Shoenfeld Y

    更新日期:1995-06-01 00:00:00

  • Twenty-year follow-up: an unusual case of nephropathy of antiphospholipid syndrome.

    abstract::Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...


    pub_type: 杂志文章


    authors: Lin YQ,Lakshminarayanan S,Yamase H,Palmisano J,Parke A

    更新日期:2009-05-01 00:00:00

  • Using the GRADE system in diagnostic strategy: the case of antiphospholipid syndrome.

    abstract::Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strat...


    pub_type: 杂志文章


    authors: Mendes de Abreu M,Levy RA,Wahl D

    更新日期:2014-10-01 00:00:00

  • Cumulative dose of hydroxychloroquine is associated with a decrease of resting heart rate in patients with systemic lupus erythematosus: a pilot study.

    abstract:INTRODUCTION:The use of hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE) offers a wide range of benefits. However, there are evidence in favour of cardiotoxicity, including heart conduction disturbances and congestive heart failure. OBJECTIVE:To determine the effects of HCQ in the resting h...


    pub_type: 杂志文章


    authors: Cairoli E,Danese N,Teliz M,Bruzzone MJ,Ferreira J,Rebella M,Cayota A

    更新日期:2015-10-01 00:00:00

  • Infant perinatal thrombosis and antiphospholipid antibodies: a review.

    abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...


    pub_type: 杂志文章,评审


    authors: Boffa MC,Lachassinne E

    更新日期:2007-01-01 00:00:00

  • Sexual dysfunction in Egyptian females with systemic lupus erythematosus: a cross sectional study.

    abstract:OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...


    pub_type: 杂志文章


    authors: Dorgham D,Haggag HM,Attia DH

    更新日期:2020-08-01 00:00:00

  • Preliminary study on the changes of ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age.

    abstract::Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...


    pub_type: 杂志文章


    authors: Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

    更新日期:2018-03-01 00:00:00

  • Corrigendum to "A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus".

    abstract::Corrigendum to A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus by C Cutler et al. Published in Lupus (2018) 27, 762-770. DOI: 10.1177/0961203317746246 . The authors wish to highlight the following correction. The subheading in Table 5 shoul...


    pub_type: 杂志文章,已发布勘误



    更新日期:2018-12-01 00:00:00

  • Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies.

    abstract::Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...


    pub_type: 共识发展会议,杂志文章,评审


    authors: Chapman J,Rand JH,Brey RL,Levine SR,Blatt I,Khamashta MA,Shoenfeld Y

    更新日期:2003-01-01 00:00:00

  • Lupus nephritis in Croatian children: clinicopathologic findings and outcome.

    abstract::We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...


    pub_type: 杂志文章


    authors: Batinić D,Milošević D,Čorić M,Topalović-Grković M,Jelušić M,Turudić D

    更新日期:2015-03-01 00:00:00

  • Tumour necrosis factor alpha in systemic lupus erythematosus and anti-DNA autoantibody production.

    abstract::Tumour necrosis factor (TNFalpha) is a cytokine with a wide range of diverse and at times paradoxical effects. These include immunoregulatory, lymphoid organogenesis and pro-inflammatory effects. In recent years, TNFalpha has become a focus of interest more for its inflammatory effects in a number of chronic autoimmun...


    pub_type: 杂志文章,评审


    authors: Mageed RA,Isenberg DA

    更新日期:2002-01-01 00:00:00

  • Association between HLA class II antigens and primary antiphospholipid syndrome from the south of Spain.

    abstract::Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...


    pub_type: 杂志文章


    authors: Camps MT,Cuadrado MJ,Ocón P,Alonso A,Gutierrez A,Guil M,Grana MI,de Ramón E

    更新日期:1995-02-01 00:00:00

  • Usefulness of pleural effusion antinuclear antibodies in the diagnosis of lupus pleuritis.

    abstract::We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of ≥1 : 160, and the ratio of pleural effusion to serum ANA of ≥1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural eff...


    pub_type: 杂志文章


    authors: Toworakul C,Kasitanon N,Sukitawut W,Wichinun R,Louthrenoo W

    更新日期:2011-10-01 00:00:00