Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity.


:Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and immunosuppressive treatment, while the behavior of anti-extractable nuclear antigen (ENA) over time is less well understood. This study sought to determine the correlation between historical autoantibody tests and current testing in patients with SLE. Three hundred and two SLE patients from the ACR Reclassification of SLE (AROSE) database with both historical and current laboratory data were selected for analysis. The historical laboratory data were compared with the current autoantibody tests done at the reference laboratory and tested for agreement using percent agreement and Kappa statistic. Serologic tests included ANA, anti-dsDNA, anti-Smith, anti-ribonucleoprotein (RNP), anti-Ro, anti-La, rheumatoid factor (RF), C3 and C4. Among those historically negative for immunologic markers, a current assessment of the markers by the reference laboratory generally yielded a low percentage of additional positives (3-13%). However, 6/11 (55%) of those historically negative for ANA were positive by the reference laboratory, and the reference laboratory test also identified 20% more patients with anti-RNP and 18% more with RF. Among those historically positive for immunologic markers, the reference laboratory results were generally positive on the same laboratory test (range 57% to 97%). However, among those with a history of low C3 or C4, the current reference laboratory results indicated low C3 or C4 a low percentage of the time (18% and 39%, respectively). ANA positivity remained positive over time, in contrast to previous studies. Anti-Ro, La, RNP, Smith and anti-dsDNA antibodies had substantial agreement over time, while complement had less agreement. This variation could partially be explained by variability of the historical assays, which were done by local laboratories over varying periods of time. Variation in the results for complement, however, is more likely to be explained by response to treatment. These findings deserve consideration in the context of diagnosis and enrolment in clinical trials.






Ippolito A,Wallace DJ,Gladman D,Fortin PR,Urowitz M,Werth V,Costner M,Gordon C,Alarcón GS,Ramsey-Goldman R,Maddison P,Clarke A,Bernatsky S,Manzi S,Bae SC,Merrill JT,Ginzler E,Hanly JG,Nived O,Sturfelt G,Sanchez-Gu




Has Abstract


2011-03-01 00:00:00
















  • Annexin A2: biology and relevance to the antiphospholipid syndrome.

    abstract::Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial....


    pub_type: 杂志文章,评审


    authors: Cockrell E,Espinola RG,McCrae KR

    更新日期:2008-10-01 00:00:00

  • Antiphospholipid syndrome and the idiotypic network.

    abstract::To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...


    pub_type: 杂志文章


    authors: Bakimer R,Blank M,Kosashvilli D,Ichikawa K,Khamashta MA,Hughes GR,Koike T,Shoenfeld Y

    更新日期:1995-06-01 00:00:00

  • Environmental exposures, epigenetic changes and the risk of lupus.

    abstract::A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that in...


    pub_type: 杂志文章,评审


    authors: Somers EC,Richardson BC

    更新日期:2014-05-01 00:00:00

  • Serum osteoprotegrin (OPG) in subclinical atherosclerosis in systemic lupus erythematosus.

    abstract::Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...


    pub_type: 杂志文章,随机对照试验


    authors: Kiani AN,Aukrust P,Ueland T,Hollan I,Barr E,Magder LS,Petri M

    更新日期:2017-07-01 00:00:00

  • Antiphospholipid syndrome induced by HIV.

    abstract::A 24-y-old male who developed necrotic lesions on the lower extremities together with testicular thrombosis necessitating orchiectomy, demonstrated high level IgG anticardiolipin (aCL) associated with acute HIV infection. This is one of the first cases describing a close relationship between viral infection and the cl...


    pub_type: 杂志文章


    authors: Leder AN,Flansbaum B,Zandman-Goddard G,Asherson R,Shoenfeld Y

    更新日期:2001-01-01 00:00:00

  • Ultrasonographic abnormalities and inter-reader reliability in Danish patients with systemic lupus erythematosus - a comparison with clinical examination of wrist and metacarpophalangeal joints.

    abstract:OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...


    pub_type: 杂志文章


    authors: Dreyer L,Jacobsen S,Juul L,Terslev L

    更新日期:2015-06-01 00:00:00

  • Altered hippocampal functional connectivity in primary Sjögren syndrome: a resting-state fMRI study.

    abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...


    pub_type: 杂志文章


    authors: Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen W

    更新日期:2020-04-01 00:00:00

  • Improving the prognosis of SLE without prescribing lupus drugs and the primary care paradox.

    abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...


    pub_type: 杂志文章


    authors: Wallace DJ

    更新日期:2008-02-01 00:00:00

  • Differential expression of factors involved in the intrinsic and extrinsic apoptotic pathways in juvenile systemic lupus erythematosus.

    abstract::Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...


    pub_type: 杂志文章


    authors: Midgley A,Mayer K,Edwards SW,Beresford MW

    更新日期:2011-01-01 00:00:00

  • SLEDAI-2K Responder Index 50 captures 50% improvement in disease activity over 10 years.

    abstract:OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...


    pub_type: 杂志文章


    authors: Touma Z,Gladman DD,Ibañez D,Urowitz MB

    更新日期:2012-10-01 00:00:00

  • Recurrent cerebral infarctions in polyarteritis nodosa with circulating antiphospholipid antibodies and mitral valve disease.

    abstract::A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...


    pub_type: 杂志文章


    authors: Morelli S,Perrone C,Paroli M

    更新日期:1998-01-01 00:00:00

  • Mechanisms involved in the p62-73 idiopeptide-modulated delay of lupus nephritis in SNF(1) mice.

    abstract::The F(1) progeny of the (SWR × NZB) cross develop a lupus-like disease with high serum titers of autoantibodies, and increased frequency and severity of immune complex-mediated glomerulonephritis in females. In previous work, we found that an idiotypic peptide corresponding to aa62-73 (p62-73) of the heavy chain varia...


    pub_type: 杂志文章


    authors: Nyland JF,Stoll ML,Jiang F,Feng F,Gavalchin J

    更新日期:2012-12-01 00:00:00

  • The lupus patient with positive rheumatoid factor.

    abstract::Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...


    pub_type: 杂志文章


    authors: Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

    更新日期:2018-07-01 00:00:00

  • Clinical management of Lupus patients during the COVID-19 pandemic.

    abstract::Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the virus causing Coronavirus disease 2019 (COVID-19), has had a huge impact on health services with a high mortality associated with complications including pneumonia and acute respiratory distress syndrome. Historical evidence suggests that Lupus patients h...


    pub_type: 杂志文章,评审


    authors: Mason A,Rose E,Edwards CJ

    更新日期:2020-11-01 00:00:00

  • Risk of complications of ultrasound-guided renal biopsy for adult and pediatric patients with systemic lupus erythematosus.

    abstract::Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imagin...


    pub_type: 杂志文章


    authors: Sun YS,Sun IT,Wang HK,Yang AH,Tsai CY,Huang CJ,Huang DF,Lai CC

    更新日期:2018-04-01 00:00:00

  • Anticardiolipin antibodies in infections are heterogenous in their dependency on beta 2-glycoprotein I: analysis of anticardiolipin antibodies in leprosy.

    abstract::We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...


    pub_type: 杂志文章


    authors: Hojnik M,Gilburd B,Ziporen L,Blank M,Tomer Y,Scheinberg MA,Tincani A,Rozman B,Shoenfeld Y

    更新日期:1994-12-01 00:00:00

  • Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

    abstract:OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...


    pub_type: 杂志文章,meta分析


    authors: Lee YH,Bae SC

    更新日期:2016-10-01 00:00:00

  • Lupus erythematosus tumidus in systemic lupus erythematosus: novel association and possible role of early treatment in prevention of discoid lupus erythematosus.

    abstract::Skin involvement in systemic lupus erythematosus (SLE) occurs in varied forms. Lupus erythematosus tumidus (LET) is not known to occur with SLE. In our patient presented below, LET occurred in a patient with SLE. Some of the lesions progressed to scarring discoid lesions, while others responded very well to hydoxychlo...


    pub_type: 杂志文章


    authors: Jolly M,Laumann AE,Shea CR,Utset TO

    更新日期:2004-01-01 00:00:00

  • Protein S deficiency revealed by skin necrosis in a patient with lupus.

    abstract::Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had...


    pub_type: 杂志文章


    authors: Plana-Pla A,Bielsa Marsol I,Ferrandiz Foraster C

    更新日期:2019-06-01 00:00:00

  • Role of HLA in congenital heart block: susceptibility alleles in children.

    abstract::Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading ...


    pub_type: 杂志文章


    authors: Sirén MK,Julkunen H,Kaaja R,Ekblad H,Koskimies S

    更新日期:1999-01-01 00:00:00

  • The association of malignancy with SLE: an analysis of 150 patients under long-term review.

    abstract::We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...


    pub_type: 杂志文章


    authors: Menon S,Snaith ML,Isenberg DA

    更新日期:1993-06-01 00:00:00

  • Impact of hypertension and hyperhomocysteinemia on arterial thrombosis in primary antiphospholipid syndrome.

    abstract::The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...


    pub_type: 杂志文章


    authors: de Souza AW,Silva NP,de Carvalho JF,D'Almeida V,Noguti MA,Sato EI

    更新日期:2007-01-01 00:00:00

  • Effect of immunosuppressive therapies on survival of systemic lupus erythematosus: a propensity score analysis of a longitudinal cohort.

    abstract::Objectives The aim of this study was to study the relationship between immunosuppressive drug treatment and survival in patients with systemic lupus erythematosus (SLE). Methods Patients who fulfilled four or more American College of Rheumatology criteria for SLE were followed longitudinally. Clinical characteristics,...


    pub_type: 杂志文章


    authors: Mok CC,Tse SM,Chan KL,Ho LY

    更新日期:2018-04-01 00:00:00

  • Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis.

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    pub_type: 杂志文章


    authors: Arora M,Arora R,Tiwari SC,Das N,Srivastava LM

    更新日期:2000-01-01 00:00:00

  • Safety and efficacy of thrombopoeitin mimetics for refractory immune thrombocytopenia purpura in patients with systemic lupus erythematosus or antiphospholipid syndrome: a case series.

    abstract::Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...


    pub_type: 杂志文章


    authors: Lusa A,Carlson A

    更新日期:2018-09-01 00:00:00

  • Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice.

    abstract::Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...


    pub_type: 杂志文章


    authors: Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

    更新日期:2009-05-01 00:00:00

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    abstract::Concerns regarding the safety and efficacy of immunization in patients with SLE have persisted for over 60 years, despite the increased risk of infection in these patients. There are many anecdotal case reports of SLE induction or exacerbation following immunization, but overall, these events seem to be very rare. Evi...


    pub_type: 杂志文章,评审


    authors: O'Neill SG,Isenberg DA

    更新日期:2006-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Liu G,Wang H,Le J,Lan L,Xu Y,Yang Y,Chen J,Han F

    更新日期:2019-03-01 00:00:00

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    abstract::Data related to the disease course of patients with systemic lupus erythematosus (SLE) with special attention to the persistence of disease activity in the long term are scarce. At this moment reliable figures are only known about the survival rate as a measure of outcome. The aim of this multicenter study was to desc...


    pub_type: 杂志文章,多中心研究


    authors: Swaak AJ,van den Brink HG,Smeenk RJ,Manger K,Kalden JR,Tosi S,Domljan Z,Rozman B,Logar D,Pokorny G,Kovacs L,Kovacs A,Vlachoyiannopoulos PG,Moutsopoulos HM,Chwalinska-Sadowska H,Kiss E,Cikes N,Anic B,Schneider M,Fisc

    更新日期:2001-01-01 00:00:00

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    abstract::Leukopenia and anaemia are observed in about a fifth of all patients with systemic lupus erythematosus (SLE) and may be due either to the destruction of blood cells or their decreased production. The former may be humoral or cell-mediated or result from apoptosis of peripheral blood cells. Several observations suggest...


    pub_type: 杂志文章


    authors: Tiefenthaler M,Bacher N,Linert H,Mühlmann O,Hofer S,Sepp N,Amberger A,Geisen F,Obermoser G,Konwalinka G

    更新日期:2003-01-01 00:00:00