Abstract:
:This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus erythematosus (SLE) presented with a seizure followed by frontal lobe dysfunction clinically. An electroencephalogram (EEG) showed bilateral independent PLEDs in the frontal region. A magnetic resonance image of the brain showed white-matter changes in the frontal periventricular region. Cerebral angiogram did not reveal any evidence of vasculitis. A cerebral SPECT with tracer injected during the EEG showing PLEDs showed a reduction in CBF in the frontal regions. Clinical recovery was observed with intravenous immunoglobulin. This case shows that PLEDs can be seen with white-matter changes in SLE.
journal_name
Lupusjournal_title
Lupusauthors
Aye SM,Lim KS,Ramli NM,Tan CTdoi
10.1177/0961203312474705subject
Has Abstractpub_date
2013-04-01 00:00:00pages
510-4issue
5eissn
0961-2033issn
1477-0962pii
0961203312474705journal_volume
22pub_type
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