Rate, pattern and factors related to damage in Brazilian systemic lupus erythematosus patients.

abstract：INTRODUCTION:Several studies have shown that Hispanic patients generally experience a worse renal prognosis than non-Hispanic white patients with lupus. To date, there is no report on American College of Rheumatology (ACR) renal response criteria (ACR-RRC) in patients from Latin America. OBJECTIVE:To evaluate treatmen...

journal_title：Lupus

authors： Vinicki JP,Paniego FM,De Rosa G,Dubinsky D,Laborde HA,Marini A,Nasswetter G

更新日期：2016-02-01 00:00:00

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor gamma increasingly used in the treatment of type 2 diabetes. Both in vitro and in vivo studies provide evidence that TZDs have anti-inflammatory properties. TZDs inhibit macrophage activation and decrease inflammatory cytokin...

journal_title：Lupus

authors： Consoli A,Devangelio E

更新日期：2005-01-01 00:00:00

abstract：:Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the...

journal_title：Lupus

authors： Farhey Y,Hess EV

更新日期：1997-01-01 00:00:00

abstract：:Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...

journal_title：Lupus

authors： Zoma A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES:The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METH...

journal_title：Lupus

authors： Gonçalves MJ,Sousa S,Inês LS,Duarte C,Borges J,Silva C,Romão VC,Terroso G,Bernardes M,Cerqueira M,Raposo A,Sequeira G,Barcelos A,Macieira C,Canas da Silva J,Costa L,Pereira da Silva JA,Cunha-Miranda L,Da Silva JA,Ca

更新日期：2015-03-01 00:00:00

abstract：:HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene, which was identified as a candidate gene for SLE susceptibility in lupus mouse model. We determined these gene expressions in leukocytes from 20 SLE patients and 10 healthy controls and in renal biopsies from 29 SLE patients and 15 kidney donor...

journal_title：Lupus

authors： Kimkong I,Avihingsanon Y,Hirankarn N

更新日期：2009-10-01 00:00:00

abstract：:This study was designed to investigate whether Foxp3( +) regulatory T (Treg) cells play a role in the histopathologic changes of primary Sjögren's Syndrome (pSS) and to evaluate other factors possibly associated with Foxp3(+) Treg cells in pSS patients. The number of FoxP3-expressing T cells in peripheral blood (PB) o...

journal_title：Lupus

authors： Sarigul M,Yazisiz V,Bassorgun CI,Ulker M,Avci AB,Erbasan F,Gelen T,Gorczynski RM,Terzioglu E

更新日期：2010-02-01 00:00:00

abstract：:Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...

journal_title：Lupus

authors： Bedaiwi M,Alkubeyyer MA,Al Arfaj AS

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:The objective of this study is to determine whether serum concentrations of B cell activating factor from the tumour necrosis factor family (BAFF) and/or a proliferation-inducing ligand (APRIL) are associated with clinical manifestations of systemic lupus erythematosus (SLE). METHODS:BAFF and APRIL concen...

journal_title：Lupus

authors： Vincent FB,Northcott M,Hoi A,Mackay F,Morand EF

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina. METHODS:This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint: overall clinical r...

journal_title：Lupus

authors： Babini A,Cappuccio AM,Caprarulo C,Casado G,Eimon A,Figueredo H,García MA,Magri S,Mannucci P,Perez Rodriguez S,Pons-Estel BA,Velozo EJ,Iglesias-Rodriguez M,Streger G

更新日期：2020-10-01 00:00:00

abstract：:Lupus nephritis during pregnancy increases morbidity and mortality for mother and baby. Flares are difficult to treat as many therapeutic options are teratogenic or fetotoxic. Steroids alone may be unable to control disease activity and are associated with higher rates of preterm delivery, sepsis and gestational diabe...

journal_title：Lupus

authors： Webster P,Wardle A,Bramham K,Webster L,Nelson-Piercy C,Lightstone L

更新日期：2014-10-01 00:00:00

abstract：:Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...

journal_title：Lupus

authors： Schnitz WM,Lister KA,McCarty GA

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...

journal_title：Lupus

authors： Lee YH,Bae SC

更新日期：2016-10-01 00:00:00

abstract：:Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...

journal_title：Lupus

authors： Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...

journal_title：Lupus

authors： Bengtsson AA,Sturfelt G,Truedsson L,Blomberg J,Alm G,Vallin H,Rönnblom L

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To determine if dehydroepiandrosterone (DHEA) is beneficial in severe systemic lupus erythematosus (SLE). METHODS:A double-blinded, placebo-controlled, randomized clinical trial in 21 patients with severe and active SLE, manifestated primarily by nephritis, serositis or hematological abnormalities. In additi...

journal_title：Lupus

authors： van Vollenhoven RF,Park JL,Genovese MC,West JP,McGuire JL

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Since enhanced cardiac magnetic resonance imaging (cMRI) signals have been associated with lupus disease activity in humans prior to renal failure and novel, cardiac-focused therapeutic strategies could be investigated with an associated animal model, autoimmune myocarditis was characterized in murine lupus n...

journal_title：Lupus

authors： Young NA,Jablonski K,Schwarz E,Okafor I,Hampton J,Valiente GR,Henry C,Harb P,Barger J,Bratasz A,Kalyanasundaram A,Ardoin SP,Jarjour WN

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...

journal_title：Lupus

authors： Bearne LM,Bieles J,Georgopoulou S,Andrews J,Tully A,Stolarchuk-Prowting K,Williamson T,Suarez BS,Nel L,D'Cruz D,Lempp H

更新日期：2020-07-01 00:00:00

abstract：:Autoantibodies against prothrombin, including lupus anticoagulant antibodies (LAC), have been identified in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To identify the epitopes of LAC in patients with SLE and APS, we analyzed B cell epitopes of anti-prothrombin Abs. Prothrombi...

journal_title：Lupus

authors： Akimoto T,Akama T,Kono I,Sumida T

更新日期：1999-01-01 00:00:00

abstract：:Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...

journal_title：Lupus

authors： Jarrett P,Thornley S,Scragg R

更新日期：2016-11-01 00:00:00

abstract：:Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...

journal_title：Lupus

authors： Gasparin AA,Pamplona Bueno de Andrade N,Hax V,Tres GL,Veronese FV,Monticielo OA

更新日期：2019-03-01 00:00:00

abstract：:The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...

journal_title：Lupus

authors： Qian G,Ran X,Zhou CX,Deng DQ,Zhang PL,Guo Y,Luo JH,Zhou XH,Xie H,Cai M

更新日期：2014-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multiple organ involvement. B-lymphocyte activity plays a pivotal role in the development and course of the disease. A newly developed agent called belimumab has recently been approved to treat active, autoantibody positive SLE as an add-on to st...

journal_title：Lupus

authors： Parodis I,Axelsson M,Gunnarsson I

更新日期：2013-04-01 00:00:00

abstract：:Only recently Bartonella species have been recognized as important human pathogens. Cat scratch disease (CSD), caused by infection with Bartonella henselae, shows a steady increase in the number of cases throughout the world. We report a case of an 18-year-old woman with systemic lupus erythematosus (SLE) who presente...

journal_title：Lupus

authors： Gaubitz M,Herrmann M,Shahin M,Schotte H,Willeke P,Domschke W

更新日期：2001-01-01 00:00:00

abstract：:Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...

journal_title：Lupus

authors： Petri M

更新日期：2010-04-01 00:00:00

abstract：:Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...

journal_title：Lupus

authors： Boffa MC,Lachassinne E

更新日期：2007-01-01 00:00:00

abstract：:We report the experience from the Antiphospholipid Antibodies (aPL) Regional Consortium in northwest Italy, meant to support clinical research and foster collaboration among health professionals regarding the diagnosis and management of antiphospholipid syndrome (APS) patients. This cohort-study (APS Piedmont Cohort) ...

journal_title：Lupus

authors： Bertero MT,Bazzan M,Carignola R,Montaruli B,Silvestro E,Sciascia S,Vaccarino A,Baldovino S,Roccatello D,Antiphospholipid Piedmont Consortium.

更新日期：2012-06-01 00:00:00

abstract：:Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...

journal_title：Lupus

authors： Karim MY,Ruiz-Irastorza G,Khamashta MA,Hughes GR

更新日期：2001-01-01 00:00:00

abstract：:Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...

journal_title：Lupus

authors： Beresford MW,Cleary AG,Sills JA,Couriel J,Davidson JE

更新日期：2005-01-01 00:00:00