Characterization of damage in Portuguese lupus patients: analysis of a national lupus registry.

abstract：:The antiphospholipid or Hughes syndrome is the association between antiphospholipid antibodies (aPL), venous and arterial thromboses and pregnancy morbidity. Antiphospholipid syndrome (APS) commonly coexists with autoimmune diseases usually systemic lupus erythematosus (SLE), when it is known as secondary APS. When pr...

journal_title：Lupus

authors： Karim MY,Alba P,Tungekar MF,Abbs IC,Khamashta MA,Hughes GR,Hunt BJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). OBJECTIVES:The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration o...

journal_title：Lupus

authors： Cutillas-Marco E,Marquina-Vila A,Grant WB,Vilata-Corell JJ,Morales-Suárez-Varela MM

更新日期：2014-06-01 00:00:00

abstract：:Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...

journal_title：Lupus

authors： Lusa A,Carlson A

更新日期：2018-09-01 00:00:00

abstract：:The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...

journal_title：Lupus

authors： Friedman AW,Tewi MB,Ahn C,McGwin G Jr,Fessler BJ,Bastian HM,Baethge BA,Reveille JD,Alarcón GS,LUMINA Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Background and objective African-Americans and Hispanic-Americans with lupus are the two most common minority groups who receive kidney transplants in the USA. It is unknown if African-Americans and Hispanic-Americans with lupus have similar outcomes after kidney transplantation. In this study, we assessed whether Afr...

journal_title：Lupus

authors： Gonzalez-Suarez ML,Contreras G

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the occurrence of idiopathic intracranial hypertension (IIH) in patients with systemic lupus erythematosus (SLE) and to describe the manifestations, treatments and outcomes in these patients. METHODS:We reviewed the medical records of 1084 patients with SLE followed up from January 1997 to June 2...

journal_title：Lupus

authors： Kim JM,Kwok SK,Ju JH,Kim HY,Park SH

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...

journal_title：Lupus

authors： Jesus AA,Liphaus BL,Silva CA,Bando SY,Andrade LE,Coutinho A,Carneiro-Sampaio M

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive pae...

journal_title：Lupus

authors： Blanco-Favela F,Quintal MaG,Chavez-Rueda AK,Leaños-Miranda A,Berron-Peres R,Baca-Ruiz V,Lavalle-Montalvo C

更新日期：2001-01-01 00:00:00

abstract：:Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading ...

journal_title：Lupus

authors： Sirén MK,Julkunen H,Kaaja R,Ekblad H,Koskimies S

更新日期：1999-01-01 00:00:00

abstract：:With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ systems. Seventy seven percent of SLE sera had at least one Aab and 56...

journal_title：Lupus

authors： Villarreal GM,Drenkard C,Villa AR,Slor H,Shafrir S,Bakimer R,Shoenfeld Y,Alarcón-Segovia D

更新日期：1997-01-01 00:00:00

abstract：:We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...

journal_title：Lupus

authors： Menon S,Snaith ML,Isenberg DA

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...

journal_title：Lupus

authors： Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. OBJECTIVES:The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions -986 (G/A), -602 (G/A), ...

journal_title：Lupus

authors： Elkoumi MA,Emam AA,Allah MAN,Sherif AH,Abdelaal NM,Mosabah A,Zakaria MT,Soliman MM,Salah A,Sedky YM,Mashali MH,Elashkar SSA,Hafez SFM,Hashem MIA,Elshreif AM,Youssef M,Fahmy DS,Sallam MM,Nawara AM,Elgohary EA,Ahmed

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse autoantibodies' titres modulation during belimumab treatment in 50 patients with systemic lupus erythematosus (SLE). METHODS:Sera were collected at belimumab start (T0) and every six months until the 24th month. Disease activity index (SLEDAI-2K) was analysed at eve...

journal_title：Lupus

authors： Cavazzana I,Kumar R,Pozzari C,Ottaviani R,Fredi M,Piantoni S,Andreoli L,Tincani A,Franceschini F

更新日期：2019-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...

journal_title：Lupus

authors： Lau CS,Yin G,Mok MY

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...

journal_title：Lupus

authors： Wang SH,Chang YS,Liu CJ,Lai CC,Chen TJ,Chen WS

更新日期：2014-06-01 00:00:00

abstract：:This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus er...

journal_title：Lupus

authors： Aye SM,Lim KS,Ramli NM,Tan CT

更新日期：2013-04-01 00:00:00

abstract：:Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In thi...

journal_title：Lupus

authors： Gordon PA,George J,Khamashta MA,Harats D,Hughes G,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：:The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...

journal_title：Lupus

authors： García-Carrasco M,Jiménez-Herrera EA,Gálvez-Romero JL,Mendoza-Pinto C,Méndez-Martínez S,Etchegaray-Morales I,Munguía-Realpozo P,Vázquez de Lara-Cisneros L,Santa Cruz FJ,Cervera R

更新日期：2018-12-01 00:00:00

abstract：:Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...

journal_title：Lupus

authors： Ricarte IF,Dutra LA,Abrantes FF,Toso FF,Barsottini OGP,Silva GS,de Souza AWS,Andrade D

更新日期：2018-08-01 00:00:00

abstract：:Neuropsychiatric lupus is a well-recognized complication of systemic lupus erythematosus (SLE) and encompasses a wide variety of neurological manifestations. Although isolated cranial nerve involvement is rare, it can cause significant morbidity and disability. This report describes a case with isolated vagus nerve in...

journal_title：Lupus

authors： Yu KH,Yang CH,Chu CC

更新日期：2007-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been detected in various liver diseases, particularly cirrhosis. The role of alcoholic consumption per se has been suggested. The aim of our study was to assess the prevalence of aPL in patients with alcoholic liver disease at various states and to correlate the presence of aPL w...

journal_title：Lupus

authors： Perney P,Biron-Andréani C,Joomaye Z,Fabbro-Peray P,Quénet F,Schved JF,Blanc F

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Complement activation plays a role in pathogenesis of the antiphospholipid syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 defi...

journal_title：Lupus

authors： Carrera-Marín A,Romay-Penabad Z,Papalardo E,Reyes-Maldonado E,García-Latorre E,Vargas G,Shilagard T,Pierangeli S

更新日期：2012-12-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Environmental factors appear to play a role in the pathogenesis of lupus erythematosus (LE). OBJECTIVE:To determine the association between cigarette smoking and various types of cutaneous LE. DESIGN:Retrospective descriptive study at a dermatology clinic of a tertiary referral hospital. METHODS:All patie...

journal_title：Lupus

authors： Böckle BC,Sepp NT

更新日期：2015-06-01 00:00:00

abstract：:We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...

journal_title：Lupus

authors： Cooper GS,Parks CG,Treadwell EL,St Clair EW,Gilkeson GS,Cohen PL,Roubey RA,Dooley MA

更新日期：2002-01-01 00:00:00

abstract：:Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...

journal_title：Lupus

authors： Monticielo OA,Brenol JC,Chies JA,Longo MG,Rucatti GG,Scalco R,Xavier RM

更新日期：2012-01-01 00:00:00

abstract：:This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...

journal_title：Lupus

authors： Dhillon V,Latchman D,Isenberg D

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...

journal_title：Lupus

authors： Dreyer L,Jacobsen S,Juul L,Terslev L

更新日期：2015-06-01 00:00:00

abstract：:Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended p...

journal_title：Lupus

authors： Boumpas DT,Balow JE

更新日期：1998-01-01 00:00:00