Abstract:
:Background and objective African-Americans and Hispanic-Americans with lupus are the two most common minority groups who receive kidney transplants in the USA. It is unknown if African-Americans and Hispanic-Americans with lupus have similar outcomes after kidney transplantation. In this study, we assessed whether African-Americans compared to Hispanic-Americans have worse kidney allograft survival after risk factors of rejection and other prognostic factors were matched between both groups. Methods Out of 1816 African-Americans and 901 Hispanic-Americans with lupus, who received kidney transplants between 1987 and 2006 and had complete records in the UNOS program, 478 pairs were matched in 16 baseline predictors and follow-up time employing a predicted probability of group membership. The primary outcome was kidney allograft survival. Main secondary outcomes were rejection, allograft failure attributed to rejection, and mortality. Results Matched pairs were predominantly women (81%) with the mean age of 36 years. 96% were on dialysis before transplantation. 89% of recipients received kidneys from deceased donors and 15.5% from expanded criteria donors. 12% of recipients had zero HLA mismatch. African-Americans compared to Hispanic-Americans had lower cumulative allograft survival during 12-year follow-up ( p < 0.001). African-Americans compared to Hispanic-Americans had higher rates of rejection (10.4 vs 6.73 events/100 patients-years; p = 0.0002) and allograft failure attributed to rejection (6.31 vs 3.99; p = 0.0023). However, African-Americans and Hispanic-Americans had similar mortality rates (2.71 vs 2.31; p = 0.4269). Conclusions African-Americans compared to Hispanic-Americans with lupus had lower kidney allograft survival when recognized risk factors of rejection were matched between groups.
journal_name
Lupusjournal_title
Lupusauthors
Gonzalez-Suarez ML,Contreras Gdoi
10.1177/0961203317699287subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1269-1277issue
12eissn
0961-2033issn
1477-0962journal_volume
26pub_type
杂志文章相关文献
LUPUS文献大全abstract::Central nervous system (CNS) involvement may occur in 20-70% of systemic lupus erythematosus (SLE) patients where neurological symptoms are overt; this is termed neuropsychiatric lupus or NPSLE. This review summarizes evidence that damage to the brain endothelium forming the blood-brain barrier (BBB) is a contributory...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu501oa
更新日期:2003-01-01 00:00:00
abstract::Autoantibodies to phospholipids other than cardiolipin have received less attention, to date, than anti-cardiolipin antibodies. This review focuses on these antibodies and potential roles for both phospholipid and protein in their reactivity. We review data in the literature indicating that antibodies to phosphatidyle...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500534
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320942296
更新日期:2020-10-01 00:00:00
abstract::Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2213oa
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312454344
更新日期:2012-10-01 00:00:00
abstract::Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. This r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319835320
更新日期:2019-04-01 00:00:00
abstract::Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318776110
更新日期:2018-08-01 00:00:00
abstract::The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084722
更新日期:2008-02-01 00:00:00
abstract::Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319826695
更新日期:2019-03-01 00:00:00
abstract::Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203317734922
更新日期:2018-04-01 00:00:00
abstract::The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis- (PM) and dermatomyositis- (DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2158oa
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract::Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306073137
更新日期:2007-01-01 00:00:00
abstract::The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300206
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203319862610
更新日期:2019-09-01 00:00:00
abstract::Cyclophosphamide (CYC) is used in severe neuropsychiatric systemic lupus erythematosus (NPSLE), but long-term data regarding its efficacy and safety are lacking. We identified NPSLE cases who received CYC from two centres during the period 1999-2013 and had regular follow-up. General and neuropsychiatric outcome at la...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315622821
更新日期:2016-05-01 00:00:00
abstract::Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500504
更新日期:1996-10-01 00:00:00
abstract::To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308101714
更新日期:2009-07-01 00:00:00
abstract::Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316686705
更新日期:2017-09-01 00:00:00
abstract::Recent accumulated evidence suggests that prolactin (PRL) is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Our aim was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation with disease activity. PRL plasma levels...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678920361
更新日期:1998-01-01 00:00:00
abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086267
更新日期:2008-02-01 00:00:00
abstract::This study investigates specificity, sensitivity and concomitant presence of antibodies against histone H1 (H1), nucleosomes (NUC), chromatin (CHR) and dsDNA in patients with systemic lupus erythematosus (SLE), analyses their association with SLE disease activity and characterizes the immunodominant epitope reactivity...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu247oa
更新日期:2002-01-01 00:00:00
abstract::The pathogenesis and therapy of shrinking lungs syndrome in patients with systemic lupus erythematosus remains controversial. It has been previously reported that corticosteroid treatment can be effective. We report a patient with shrinking lungs syndrome who presented a good response to inhaled beta-agonist therapy. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600413
更新日期:1997-01-01 00:00:00
abstract::With the use of low-dose heparin, fetal survival of aPL pregnancies is 70-80%, but prematurity and intrauterine growth restriction are common. It is likely, but not proven, that dysregulated placental coagulation and resultant vasculopathy are the cause of fetal loss. Details of dysregulated coagulation remain to be d...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700219
更新日期:1998-01-01 00:00:00
abstract::Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345742
更新日期:2010-01-01 00:00:00
abstract::High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311399606
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:To compare and rank currently available pharmacological interventions for the prevention of recurrent miscarriage (RM) in women with antiphospholipid syndrome (APS). METHODS:A search was performed using PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, CNKI, ClinicalTrials....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320967097
更新日期:2021-01-01 00:00:00
abstract::We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089442
更新日期:2008-08-01 00:00:00
abstract::A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307081421
更新日期:2007-01-01 00:00:00
abstract::Skin involvement in systemic lupus erythematosus (SLE) occurs in varied forms. Lupus erythematosus tumidus (LET) is not known to occur with SLE. In our patient presented below, LET occurred in a patient with SLE. Some of the lesions progressed to scarring discoid lesions, while others responded very well to hydoxychlo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu473cr
更新日期:2004-01-01 00:00:00