Abstract:
:With the use of low-dose heparin, fetal survival of aPL pregnancies is 70-80%, but prematurity and intrauterine growth restriction are common. It is likely, but not proven, that dysregulated placental coagulation and resultant vasculopathy are the cause of fetal loss. Details of dysregulated coagulation remain to be described. Opportunities remain to determine the role of coagulopathy in repeated pregnancy loss, identify a critical event or window to which intervention might be directed, identify maternal (and fetal) characteristics other than aPL that determine fetal loss, describe toxicity profiles of current treatments, develop more specific, less toxic therapies, and describe long-term fetal and maternal outcomes.
journal_name
Lupusjournal_title
Lupusauthors
Lockshin MDdoi
10.1177/096120339800700219subject
Has Abstractpub_date
1998-01-01 00:00:00pages
S86-9eissn
0961-2033issn
1477-0962journal_volume
7 Suppl 2pub_type
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