Mortality and years of potential life loss in systemic lupus erythematosus: a population-based cohort study.

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:Objectives The aim of this study was to study the relationship between immunosuppressive drug treatment and survival in patients with systemic lupus erythematosus (SLE). Methods Patients who fulfilled four or more American College of Rheumatology criteria for SLE were followed longitudinally. Clinical characteristics,...

journal_title：Lupus

authors： Mok CC,Tse SM,Chan KL,Ho LY

更新日期：2018-04-01 00:00:00

abstract：:We report a woman with systemic lupus erythematosus (SLE) with diffuse proliferative glomerulonephritis and anti-dsDNA antibodies whose serum contained autoantibodies specific for the phosphorylated form of RNA polymerase II (RNAP IIO), Su and ribosomal P antigen, as well as anti-topoisomerase I antibodies, a marker f...

journal_title：Lupus

authors： Stojanov L,Satoh M,Dooley MA,Kuwana M,Jennette JC,Reeves WH

更新日期：1995-08-01 00:00:00

abstract：:Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...

journal_title：Lupus

authors： Zoma A

更新日期：2004-01-01 00:00:00

abstract：:In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...

journal_title：Lupus

authors： Vaarala O

更新日期：1998-01-01 00:00:00

abstract：:The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...

journal_title：Lupus

authors： Touma Z,Urowitz MB,Gladman DD

更新日期：2010-01-01 00:00:00

abstract：:We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...

journal_title：Lupus

authors： Koh JH,Ko HS,Lee J,Jung SM,Kwok SK,Ju JH,Park SH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...

journal_title：Lupus

authors： Agmon-Levin N,Rosário C,Katz BS,Zandman-Goddard G,Meroni P,Cervera R,Stojanovich L,Blank M,Pierangeli S,Praprotnik S,Meis Ed,Seguro LP,Ruffatti A,Pengo V,Tincani A,Doria A,Shoenfeld Y

更新日期：2013-11-01 00:00:00

abstract：:This report considers the rare situation in which primary antiphospholipid syndrome (PAPS) is linked with thrombotic thrombocytopenic purpura (TTP). It describes the case of a young lady with PAPS, characterized by recurring cerebro-vascular abnormalities and marked livedo reticularis, combined with circulating antica...

journal_title：Lupus

authors： de Carvalho JF,Freitas CA,Lima IV,Leite CC,Lage LV

更新日期：2009-08-01 00:00:00

abstract：:The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...

journal_title：Lupus

authors： Catania G,Rossi E,Marmont A

更新日期：2012-05-01 00:00:00

abstract：:Although the importance of the anticardiolipin test in diagnosis of antiphospholipid syndrome (APS) is widely accepted, there remains much misunderstanding about the strengths and weaknesses of this assay. Several disorders result in formation of low levels of the antibody, hence the anticardiolipin test is not specif...

journal_title：Lupus

authors： Harris EN,Pierangeli SS

更新日期：2002-01-01 00:00:00

abstract：:Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...

journal_title：Lupus

authors： Anam K,Amare M,Naik S,Szabo KA,Davis TA

更新日期：2009-04-01 00:00:00

abstract：:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...

journal_title：Lupus

authors： Hasegawa K,Hayashi T

更新日期：2003-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been detected in various liver diseases, particularly cirrhosis. The role of alcoholic consumption per se has been suggested. The aim of our study was to assess the prevalence of aPL in patients with alcoholic liver disease at various states and to correlate the presence of aPL w...

journal_title：Lupus

authors： Perney P,Biron-Andréani C,Joomaye Z,Fabbro-Peray P,Quénet F,Schved JF,Blanc F

更新日期：2000-01-01 00:00:00

abstract：:A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. Autoimmune PAP is rarely associated with system...

journal_title：Lupus

authors： Nagasawa J,Kurasawa K,Maezawa R,Owada T,Hanaoka R,Fukuda T

更新日期：2013-09-01 00:00:00

abstract：:The complexity of the therapeutic approach in systemic lupus erythematosus (SLE) is increased by the large number of patients who do not respond to the first-line therapies and by relapses after initial clinical remission. In these patients, second-line drugs are often prescribed according to individual clinical decis...

journal_title：Lupus

authors： Ramos-Casals M,Soto MJ,Cuadrado MJ,Khamashta MA

更新日期：2009-08-01 00:00:00

abstract：:Sera from healthy individuals, relatives of lupus patients, and lupus patients with active disease and in remission were screened for IgG and IgM antibodies to ssDNA and dsDNA. The serum samples were also separated into IgG and IgM fractions which were screened for DNA reactivity at dilutions equivalent to those used ...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1996-12-01 00:00:00

abstract：:Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...

journal_title：Lupus

authors： Stepanić V,Corusić A,Matković V,Sentić M,Bosnić D,Mahovlić V

更新日期：2010-01-01 00:00:00

abstract：:Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imagin...

journal_title：Lupus

authors： Sun YS,Sun IT,Wang HK,Yang AH,Tsai CY,Huang CJ,Huang DF,Lai CC

更新日期：2018-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...

journal_title：Lupus

authors： Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

更新日期：2008-05-01 00:00:00

abstract：:With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ systems. Seventy seven percent of SLE sera had at least one Aab and 56...

journal_title：Lupus

authors： Villarreal GM,Drenkard C,Villa AR,Slor H,Shafrir S,Bakimer R,Shoenfeld Y,Alarcón-Segovia D

更新日期：1997-01-01 00:00:00

abstract：:Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...

journal_title：Lupus

authors： Bason C,Pagnini I,Brucato A,Maestroni S,Puccetti A,Lunardi C,Cimaz R

更新日期：2017-07-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...

journal_title：Lupus

authors： López-Pedrera Ch,Buendía P,Aguirre MA,Velasco F,Cuadrado MJ

更新日期：2006-01-01 00:00:00

abstract：:Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...

journal_title：Lupus

authors： Durupt S,Puget M,Lega JC,Durieu I,Reynaud Q

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

journal_title：Lupus

authors： De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

更新日期：2012-06-01 00:00:00

abstract：:Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strat...

journal_title：Lupus

authors： Mendes de Abreu M,Levy RA,Wahl D

更新日期：2014-10-01 00:00:00

abstract：:Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had...

journal_title：Lupus

authors： Plana-Pla A,Bielsa Marsol I,Ferrandiz Foraster C

更新日期：2019-06-01 00:00:00

abstract：:Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...

journal_title：Lupus

authors： Dotan N,Altstock RT,Schwarz M,Dukler A

更新日期：2006-01-01 00:00:00

abstract：:To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...

journal_title：Lupus

authors： Duran-Barragan S,Ruvalcaba-Naranjo H,Rodriguez-Gutierrez L,Solano-Moreno H,Hernandez-Rios G,Sanchez-Ortiz A,Ramos-Remus C

更新日期：2008-12-01 00:00:00

abstract：:We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...

journal_title：Lupus

authors： Hojnik M,Gilburd B,Ziporen L,Blank M,Tomer Y,Scheinberg MA,Tincani A,Rozman B,Shoenfeld Y

更新日期：1994-12-01 00:00:00