Protein S deficiency revealed by skin necrosis in a patient with lupus.

Abstract:

:Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had not received warfarin and without APL antibodies who developed extensive skin necrosis due to protein S deficiency. It is important to investigate protein S deficiency in patients with lupus and extensive skin ulcers as it is a sign of arterial thrombosis and venous thromboembolism.

journal_name

Lupus

journal_title

Lupus

authors

Plana-Pla A,Bielsa Marsol I,Ferrandiz Foraster C

doi

10.1177/0961203319843345

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

903-905

issue

7

eissn

0961-2033

issn

1477-0962

journal_volume

28

pub_type

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