Abstract:
:Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had not received warfarin and without APL antibodies who developed extensive skin necrosis due to protein S deficiency. It is important to investigate protein S deficiency in patients with lupus and extensive skin ulcers as it is a sign of arterial thrombosis and venous thromboembolism.
journal_name
Lupusjournal_title
Lupusauthors
Plana-Pla A,Bielsa Marsol I,Ferrandiz Foraster Cdoi
10.1177/0961203319843345subject
Has Abstractpub_date
2019-06-01 00:00:00pages
903-905issue
7eissn
0961-2033issn
1477-0962journal_volume
28pub_type
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