Abstract:
:We report a woman with systemic lupus erythematosus (SLE) with diffuse proliferative glomerulonephritis and anti-dsDNA antibodies whose serum contained autoantibodies specific for the phosphorylated form of RNA polymerase II (RNAP IIO), Su and ribosomal P antigen, as well as anti-topoisomerase I antibodies, a marker for scleroderma (SSc). Over 6 years, the patient exhibited clinical manifestations consistent with SLE without clinical evidence of scleroderma. The reactivity of her serum autoantibodies with the phosphoproteins ribosomal P, topoisomerase I, and RNAP IIO is consistent with recognition of autoepitopes comprised in part of phosphate groups. This may explain the unexpected coexistence of marker autoantibodies for SLE and scleroderma, possibly with implications for the mechanisms of autoantibody generation.
journal_name
Lupusjournal_title
Lupusauthors
Stojanov L,Satoh M,Dooley MA,Kuwana M,Jennette JC,Reeves WHdoi
10.1177/096120339500400414subject
Has Abstractpub_date
1995-08-01 00:00:00pages
314-7issue
4eissn
0961-2033issn
1477-0962journal_volume
4pub_type
杂志文章相关文献
LUPUS文献大全abstract::Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316629000
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311411598
更新日期:2011-10-01 00:00:00
abstract::To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089443
更新日期:2008-09-01 00:00:00
abstract::This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1089oa
更新日期:2004-01-01 00:00:00
abstract::The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314544186
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320942296
更新日期:2020-10-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::Objectives Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316659151
更新日期:2017-03-01 00:00:00
abstract::Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543920
更新日期:2014-12-01 00:00:00
abstract::We studied IgG and IgM anticardiolipin antibodies (aCL) by an ELISA method in 80 Mexican systemic lupus erythematosus (SLE) patients and 378 of their first degree relatives. Sixty five percent of SLE patients and 16% of their relatives were positive for aCL. We also determined allele and haplotype frequencies of Major...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600108
更新日期:1997-01-01 00:00:00
abstract::Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317721752
更新日期:2018-01-01 00:00:00
abstract::Although osteoporosis has traditionally been considered a disease of women, men also incur substantial bone loss with aging, and elderly men have age-specific hip fracture incidence rates and vertebral fracture prevalence rates that are at least half those in women. Early postmenopausal bone loss (which results in the...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339900800513
更新日期:1999-01-01 00:00:00
abstract::We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319899478
更新日期:2020-02-01 00:00:00
abstract::Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2104oa
更新日期:2005-01-01 00:00:00
abstract::We report three cases of severe haemorrhagic rupture of luteal ovarian cyst requiring surgical haemostasis in young women treated with long-term oral anticoagulation for antiphospholipid syndrome (APS) who used no contraception. At the time of bleeding, the international normalized ratios were 3.78, 4.24, and 7.11. An...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339900800614
更新日期:1999-01-01 00:00:00
abstract::Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317726378
更新日期:2018-03-01 00:00:00
abstract::This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300305
更新日期:1994-06-01 00:00:00
abstract::We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1191/0961203302lu161oa
更新日期:2002-01-01 00:00:00
abstract::Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674819
更新日期:2017-06-01 00:00:00
abstract::Although a few reports in recent years have suggested that patients with antiphospholipid antibodies (aPL) are prone to developing primary anetoderma (PA), it is still unclear how often aPL are detected in unselected PA patients. We studied nine consecutive PA patients for the presence of autoimmune antibodies and dis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu403oa
更新日期:2003-01-01 00:00:00
abstract::Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2073oa
更新日期:2005-01-01 00:00:00
abstract::This manuscript discusses our studies to date concerning the effects of unmodified prolactin (PRL) and phosphorylated PRL on immune function. Most of the discussion refers to effects of changing the ratio of these two forms in maternal PRL on gamma delta T cell development in rat pups in utero, but limited experiments...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301717164976
更新日期:2001-01-01 00:00:00
abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086267
更新日期:2008-02-01 00:00:00
abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086640
更新日期:2008-03-01 00:00:00
abstract::In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200404
更新日期:1993-08-01 00:00:00
abstract::To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308093458
更新日期:2008-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has im...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669242
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314561666
更新日期:2015-06-01 00:00:00
abstract::The objective of this study was to determine whether anticardiolipin antibodies (ACL) in SLE patients are associated with a specific pattern of lupus nephritis and/or with renal microvascular changes. Patients with SLE, followed prospectively between June 1991-May 1994 at The Wellesley Hospital Lupus Clinic, who under...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500113
更新日期:1996-02-01 00:00:00
abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646861
更新日期:2016-12-01 00:00:00