Abstract:
BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tracking echocardiography (STE) to detect left ventricular dysfunction in children with active and inactive SLE. METHODS:This prospective case-control study was carried out on 50 children with SLE. Thirty healthy age- and sex-matched children comprised the control group. The patients were further subdivided into two subgroups: active SLE and inactive SLE. Laboratory investigations undertaken included complete blood count, renal function, C3, C4, ANA, anti-dsDNA and serum N-terminal pro-B type natriuretic peptide. Echocardiographic examinations were performed on all children and included conventional echocardiography, tissue Doppler imaging (TDI) and two- and three-dimensional STE. RESULTS:There was no statistically significant difference in N-terminal pro B natriuretic peptide between the studied groups. The myocardial performance index by TDI was statistically significantly higher in SLE patients compared to controls. STE parameters were statistically significantly lower in SLE patients compared to controls. There was no correlation between STE parameters and disease activity. CONCLUSIONS:STE could be a promising technique in the early detection of subclinical left ventricular dysfunction in children with SLE.
journal_name
Lupusjournal_title
Lupusauthors
Emara M,Hafez MA,El-Bendary A,Razaky OEdoi
10.1177/0961203320942296subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1449-1455issue
11eissn
0961-2033issn
1477-0962journal_volume
29pub_type
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