Abstract:
:Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and parasite cells exist in human sera and can be profiled using glycan arrays. The use of glycan arrays for systematic screening of blood samples from multiple sclerosis (MS) and Crohn's disease (CD) patients in versus to blood samples from control groups, have lead to the discovery of a few anti glycan antibodies biomarkers enabling diagnosis and prognosis in MS and CD patients. Anti-Glc(alpha1,4)Glc(alpha) IgM antibodies were found to be specific for MS patients, enabling differentiation between MS patients and patients with other neurological diseases, with 54% sensitivity and 85% specificity. Anti-Glc(alpha1,4)Glc(alpha) IgM were found to be predictive for the conversion of patients in first acute neurological event to clinically defined MS. Anti-laminaribioside (ALCA), anti-mannobioside (AMCA) and anti-chitobioside (ACCA) antibodies were found to be specific for CD. The combined use of these antibodies enables improved diagnosis of CD versus ulcerative colitis and other gastrointestinal diseases, as well as stratification of CD patients with a more complicated disease and high risk for surgery. Anti-glycan antibodies profiling (AGAP) is a new and promising approach for development of biomarkers for diagnosis and prognosis.
journal_name
Lupusjournal_title
Lupusauthors
Dotan N,Altstock RT,Schwarz M,Dukler Adoi
10.1191/0961203306lu2331oasubject
Has Abstractpub_date
2006-01-01 00:00:00pages
442-50issue
7eissn
0961-2033issn
1477-0962journal_volume
15pub_type
杂志文章,评审相关文献
LUPUS文献大全abstract::Cyclophosphamide (CYC) is used in severe neuropsychiatric systemic lupus erythematosus (NPSLE), but long-term data regarding its efficacy and safety are lacking. We identified NPSLE cases who received CYC from two centres during the period 1999-2013 and had regular follow-up. General and neuropsychiatric outcome at la...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315622821
更新日期:2016-05-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract::Choroidal involvement in systemic lupus erythematosus (SLE) occurs infrequently. We report a 45-y-old woman with bilateral chorioretinopathy associated with SLE. Diagnosis was performed using indirect ophthalmoscopy, retinal fluorescein angiography (FA) and green indocianin angiography (ICG). In this patient chorioret...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301701549598
更新日期:2001-01-01 00:00:00
abstract::Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316676384
更新日期:2017-06-01 00:00:00
abstract::Corrigendum to A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus by C Cutler et al. Published in Lupus (2018) 27, 762-770. DOI: 10.1177/0961203317746246 . The authors wish to highlight the following correction. The subheading in Table 5 shoul...
journal_title:Lupus
pub_type: 杂志文章,已发布勘误
doi:10.1177/0961203318773684
更新日期:2018-12-01 00:00:00
abstract::Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674819
更新日期:2017-06-01 00:00:00
abstract::The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu1036oa
更新日期:2004-01-01 00:00:00
abstract::Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316678671
更新日期:2017-06-01 00:00:00
abstract::We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2312oa
更新日期:2006-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an immune-mediated disease that is responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide (Cy), represent a subset of patients at high risk of early de...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu491oa
更新日期:2004-01-01 00:00:00
abstract::Congenital heart block occurs in fetuses of Ro/SSA and La/SSB positive women. To investigate the stability of maternal autoantibody levels during pregnancy, we followed Ro52, Ro60 and La autoantibody IgG level variation and Ro52 subclass profiles longitudinally in selected congenital heart block risk pregnancies. Seru...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2309oa
更新日期:2006-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669240
更新日期:2017-04-01 00:00:00
abstract::The F(1) progeny of the (SWR × NZB) cross develop a lupus-like disease with high serum titers of autoantibodies, and increased frequency and severity of immune complex-mediated glomerulonephritis in females. In previous work, we found that an idiotypic peptide corresponding to aa62-73 (p62-73) of the heavy chain varia...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312461964
更新日期:2012-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2299oa
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Creatine supplementation has emerged as a promising non-pharmacological therapeutic strategy to counteract muscle dysfunction and low lean mass in a variety of conditions, including in pediatric and rheumatic diseases. The objective of this study was to examine the efficacy and safety of creatine supplemen...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203314546017
更新日期:2014-12-01 00:00:00
abstract::The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071870
更新日期:2006-01-01 00:00:00
abstract::In the 9-year period between 1982 and 1991, 137 patients attending a medical clinic of Queen Elizabeth Hospital, Hong Kong, were diagnosed as having systemic lupus erythematosus according to the American Rheumatism Association's criteria for classification. The female-to-male ratio was 16 to 1. Commonly the onset age ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200207
更新日期:1993-04-01 00:00:00
abstract::Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313475691
更新日期:2013-03-01 00:00:00
abstract::One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200109
更新日期:1993-02-01 00:00:00
abstract::The management of lupus nephritis is typified by popular misconceptions: that there is a 'standard of care', that treatment has well-defined aims and that the optimum length of treatment is established. In reality, however, uncertainties still exist and the evidence base remains weak. Until recently, initial therapy f...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203306075614
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The heterogeneous spectrum of systemic lupus erythematosus (SLE) often presents with secondary complications such as cardiovascular disease (CVD), infections and neoplasms. Our study assessed whether the presence of SLE independently increases or reduces the disparities, accounting for the already higher risk...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319884646
更新日期:2019-12-01 00:00:00
abstract::The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. After the onset of the disease a c...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2129oa
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319853357
更新日期:2019-06-01 00:00:00
abstract::Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100311
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320928421
更新日期:2020-07-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339100100102
更新日期:1991-11-01 00:00:00
abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500514
更新日期:1996-10-01 00:00:00
abstract::An assessment of prevalence for systemic lupus erythematosus (SLE) has been attempted for the population of far north Queensland in Australia. This huge area has a majority Caucasian population living in a tropical environment. Roughly 10% of the population comprises people of Australian Aboriginal or Torres Strait Is...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu381xx
更新日期:2003-01-01 00:00:00
abstract::A 28-year-old woman with systemic lupus erythematosus (SLE) suffered recent onset fever, headache, encephalopathy followed by severe, repeated generalized seizures. Investigations revealed limbic encephalitis. Tests for Herpes simplex encephalitis and paraneoplastic encephalomyelitis were negative. High titers anti-ri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678920523
更新日期:1998-01-01 00:00:00