Pathogenesis of the antiphospholipid antibody syndrome.

abstract：:Autoantibodies to DNA were discovered over 40 years ago following the discovery a few years earlier of the 'LE' cell phenomenon by Hargraves and colleagues in 1948. These investigators noted that, when leucocytes were incubated with serum from lupus patients, changes in the nucleus could be seen together with phagocyt...

journal_title：Lupus

authors： Mageed RA,Zack DJ

更新日期：2002-01-01 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...

journal_title：Lupus

authors： Adhikari T,Piatti A,Luggen M

更新日期：2011-10-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...

journal_title：Lupus

authors： Golder V,Connelly K,Staples M,Morand E,Hoi A

更新日期：2013-11-01 00:00:00

abstract：:Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ...

journal_title：Lupus

authors： de Groot K,Gross WL

更新日期：1998-01-01 00:00:00

abstract：:We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...

journal_title：Lupus

authors： Derksen RH,Hené RJ,Kater L

更新日期：1992-02-01 00:00:00

abstract：:We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...

journal_title：Lupus

authors： Hojnik M,Gilburd B,Ziporen L,Blank M,Tomer Y,Scheinberg MA,Tincani A,Rozman B,Shoenfeld Y

更新日期：1994-12-01 00:00:00

abstract：:Although a few reports in recent years have suggested that patients with antiphospholipid antibodies (aPL) are prone to developing primary anetoderma (PA), it is still unclear how often aPL are detected in unselected PA patients. We studied nine consecutive PA patients for the presence of autoimmune antibodies and dis...

journal_title：Lupus

authors： Hodak E,Feuerman H,Molad Y,Monselise Y,David M

更新日期：2003-01-01 00:00:00

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...

journal_title：Lupus

authors： Li SJ,Liu ZH,Zen CH,Wang QW,Wang Y,Li LS

更新日期：2007-01-01 00:00:00

abstract：:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...

journal_title：Lupus

authors： Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MA

更新日期：2012-04-01 00:00:00

abstract：:The management of lupus nephritis is typified by popular misconceptions: that there is a 'standard of care', that treatment has well-defined aims and that the optimum length of treatment is established. In reality, however, uncertainties still exist and the evidence base remains weak. Until recently, initial therapy f...

journal_title：Lupus

authors： Jayne D

更新日期：2007-01-01 00:00:00

abstract：:XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...

journal_title：Lupus

authors： Lin YJ,Wan L,Huang CM,Chen SY,Huang YC,Lai CH,Lin WY,Liu HP,Wu YS,Chen CM,Tsai YH,Tsai CH,Sheu JJ,Tsai FJ

更新日期：2009-12-01 00:00:00

abstract：:The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...

journal_title：Lupus

authors： Touma Z,Urowitz MB,Gladman DD

更新日期：2010-01-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：:The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...

journal_title：Lupus

authors： Piotrowski P,Lianeri M,Mostowska M,Wudarski M,Chwalinska-Sadowska H,Jagodzinski PP

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remain...

journal_title：Lupus

authors： Kosinski M,Gajria K,Fernandes AW,Cella D

更新日期：2013-04-01 00:00:00

abstract：:Tubulointerstitial injury is found frequently in lupus nephritis. Immune complex deposits can occur in the tubular basement membranes (TBMs), although its significance in lupus nephritis patients remains unclear. This study assessed the clinical and prognostic features of lupus nephritis patients with TBM deposits in ...

journal_title：Lupus

authors： Wang H,Xu J,Zhang X,Ren YL,Cheng M,Guo ZL,Zhang JC,Cheng H,Xing GL,Wang SX,Yu F,Zhao MH

更新日期：2018-04-01 00:00:00

abstract：:Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...

journal_title：Lupus

authors： Heidenreich U,Mayer G,Herold M,Klotz W,Stempfl Al-Jazrawi K,Lhotta K

更新日期：2009-12-01 00:00:00

abstract：:The purpose of study was to determine the nature, outcomes and associated risk factors of invasive fungal infection (IFI) in patients with systemic lupus erythematosus (SLE), and compare the incidence of IFI in patients with rheumatoid arthritis (RA). A total of 1155 patients with SLE and 2004 patients with RA were re...

journal_title：Lupus

authors： Kim HJ,Park YJ,Kim WU,Park SH,Cho CS

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...

journal_title：Lupus

authors： Leiss H,Niederreiter B,Bandur T,Schwarzecker B,Blüml S,Steiner G,Ulrich W,Smolen JS,Stummvoll GH

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...

journal_title：Lupus

authors： Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

更新日期：2013-06-01 00:00:00

abstract：:'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to...

journal_title：Lupus

authors： Kandiah DA,Krilis SA

更新日期：1996-04-01 00:00:00

abstract：:Platelet activation and decrease in platelet count characterize the development of the most feared form of antiphospholipid syndrome (APS), i.e. catastrophic APS (CAPS). We aimed to assess if immuno-affinity purified anti-β2-glycoprotein I (aβ2GPI) antibodies enhance platelet activation inducing a significant flow obs...

journal_title：Lupus

authors： Pontara E,Cheng C,Cattini MG,Bison E,Pelloso M,Denas G,Pengo V

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The objective of this report is to assess the presence and viral load of JC polyomavirus (JCV) DNA in cerebrospinal fluid (CSF) and plasma from neuropsychiatric systemic lupus erythematosus (NPSLE) patients in comparison to controls and to investigate if different types of immunosuppressive treatments were co...

journal_title：Lupus

authors： Iacobaeus E,Hopia L,Khademi M,Lundén M,Hammarin AL,Svenungsson E,Andersson M

更新日期：2013-03-01 00:00:00

abstract：:The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...

journal_title：Lupus

authors： Chen HY,Pertusi RM,Kirkland JB,Rubin BR,Jacobson EL

更新日期：1996-02-01 00:00:00

abstract：:The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...

journal_title：Lupus

authors： Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

更新日期：2004-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...

journal_title：Lupus

authors： Pineau CA,Urowitz MB,Fortin PJ,Ibanez D,Gladman DD

更新日期：2004-01-01 00:00:00

abstract：:One hundred and fifty-eight patients with SLE were prospectively studied at a tertiary referral centre in India to ascertain the prevalence and clinical profile of fibromyalgia (FM) in Indian patients with lupus. An attempt was made to determine whether socio-demographic factors or disease characteristics differ in SL...

journal_title：Lupus

authors： Handa R,Aggarwal P,Wali JP,Wig N,Dwivedi SN

更新日期：1998-01-01 00:00:00