Lupus erythematosus tumidus in systemic lupus erythematosus: novel association and possible role of early treatment in prevention of discoid lupus erythematosus.

abstract：OBJECTIVE:The objective of this paper is to investigate the incidence of both non-vertebral and vertebral fracture in female patients with systemic lupus erythematosus (SLE) and to identify risk factors for incident fracture. METHODS:In a five-year prospective study of 127 female Chinese SLE patients with an average a...

journal_title：Lupus

authors： Zhu TY,Griffith JF,Au SK,Tang XL,Kwok AW,Leung PC,Li EK,Tam LS

更新日期：2014-08-01 00:00:00

abstract：:The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis- (PM) and dermatomyositis- (DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81...

journal_title：Lupus

authors： Selva-O'Callaghan A,Labrador-Horrillo M,Muñoz-Gall X,Martínez-Gomez X,Majó-Masferrer J,Solans-Laque R,Simeon-Aznar CP,Morell-Brotard F,Vilardell-Tarrés M

更新日期：2005-01-01 00:00:00

abstract：:We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...

journal_title：Lupus

authors： Baca V,Catalán T,Villasís-Keever M,Ramón G,Morales AM,Rodríguez-Leyva F

更新日期：2006-01-01 00:00:00

abstract：:Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...

journal_title：Lupus

authors： Lambrianides A,Giles IP

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...

journal_title：Lupus

authors： Wang SH,Chang YS,Liu CJ,Lai CC,Chen TJ,Chen WS

更新日期：2014-06-01 00:00:00

abstract：:We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...

journal_title：Lupus

authors： Blanco F,Longhurst C,Watts R,Kalsi J,Wiloch HW,Youinou P,Latchman DS,Isenberg DA

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:High-mobility group box 1 protein (HMGB-1) has been implicated in the pathogenesis of lupus nephritis (LN). There is increased HMGB-1 expression in the kidneys and increased levels are observed in serum and urine of patients with LN. This study was performed to determine whether the increased urinary HMGB-...

journal_title：Lupus

authors： Jog NR,Blanco I,Lee I,Putterman C,Caricchio R

更新日期：2016-12-01 00:00:00

abstract：:Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...

journal_title：Lupus

authors： Clowse ME,Magder L,Petri M

更新日期：2005-01-01 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can have many cutaneous manifestations including malar rash, discoid rash or oral ulcer. Isolated unilateral involvement of face is uncommon in SLE. It lacks typical clinical features of LE, and may impose a diagnostic challenge for clinicians. H...

journal_title：Lupus

authors： Ha DL,Lee GW,Shin K,Kim HS,Ko HC,Kim BS,Kim MB

更新日期：2020-12-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...

journal_title：Lupus

authors： Huang Y,Chen L,Chen K,Huang F,Feng Y,Xu Z,Wang W

更新日期：2019-03-01 00:00:00

abstract：:The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between antimalarials (AM) and elevated muscle enzymes in systemic lupus erythematosus (SLE). PATIENTSMETHODS:325 lupus patients with abnormal creatine phosphokinase (CPK) for at least two consecutive clinic visits were enrolled; 54 patients on statins/fibrates (n = 43) and/or...

journal_title：Lupus

authors： Tselios K,Gladman DD,Su J,Urowitz MB

更新日期：2016-04-01 00:00:00

abstract：:This study assessed the expression of complement receptor 1 (CR1), decay accelerating factor (DAF) and membrane inhibitor of reactive lysis (CD59) on the erythrocytes and glomerulus of diffuse proliferative glomerulonephritis (DPGN) of systemic lupus erythematosus (SLE) patients using flow cytometry and immunofluoresc...

journal_title：Lupus

authors： Arora M,Arora R,Tiwari SC,Das N,Srivastava LM

更新日期：2000-01-01 00:00:00

abstract：:The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...

journal_title：Lupus

authors： Qian G,Ran X,Zhou CX,Deng DQ,Zhang PL,Guo Y,Luo JH,Zhou XH,Xie H,Cai M

更新日期：2014-12-01 00:00:00

abstract：:We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double strande...

journal_title：Lupus

authors： Miyagawa S,Uchida Y,Taira K,Higuchi M,Hashimoto K,Yoshioka A,Shirai T

更新日期：2000-01-01 00:00:00

abstract：:Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant stu...

journal_title：Lupus

authors： Zhang WT,Jin TF,Chen L

更新日期：2020-04-01 00:00:00

abstract：:C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...

journal_title：Lupus

authors： Li SJ,Liu ZH,Zen CH,Wang QW,Wang Y,Li LS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...

journal_title：Lupus

authors： Wang JM,Yuan ZC,Huang AF,Xu WD

更新日期：2019-09-01 00:00:00

abstract：:The objective of the study was to analyse the prevalence and clinical significance of hypocomplementemia in a large series of patients diagnosed either with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (APS) and its association with the main clinical, hematological and immunological fea...

journal_title：Lupus

authors： Ramos-Casals M,Campoamor MT,Chamorro A,Salvador G,Segura S,Botero JC,Yagüe J,Cervera R,Ingelmo M,Font J

更新日期：2004-01-01 00:00:00

abstract：:The objective of this study was to examine factors predictive of a decline to low levels of disease activity in a cohort of systemic lupus erythematosus (SLE) patients. Patients with SLE of Hispanic (from Texas or Puerto Rico), African-American or Caucasian ethnicity from a multiethnic cohort were included. A decline ...

journal_title：Lupus

authors： Bertoli AM,Alarcón GS,McGwin G Jr,Fernández M,Bastian HM,Fessler BJ,Vilá LM,Reveille JD,LUMINA Study Group.

更新日期：2006-01-01 00:00:00

abstract：:This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...

journal_title：Lupus

authors： Dhillon V,Latchman D,Isenberg D

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...

journal_title：Lupus

authors： Leiss H,Niederreiter B,Bandur T,Schwarzecker B,Blüml S,Steiner G,Ulrich W,Smolen JS,Stummvoll GH

更新日期：2013-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...

journal_title：Lupus

authors： Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00

abstract：:Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ...

journal_title：Lupus

authors： de Groot K,Gross WL

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To examine the potential immunologic mechanism and involvement of antiphospholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphospholipid syndrome (APS). METHODS:Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derive...

journal_title：Lupus

authors： Ziporen L,Goldberg I,Arad M,Hojnik M,Ordi-Ros J,Afek A,Blank M,Sandbank Y,Vilardell-Tarres M,de Torres I,Weinberger A,Asherson RA,Kopolovic Y,Shoenfeld Y

更新日期：1996-06-01 00:00:00

abstract：:Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In thi...

journal_title：Lupus

authors： Gordon PA,George J,Khamashta MA,Harats D,Hughes G,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...

journal_title：Lupus

authors： Adhikari T,Piatti A,Luggen M

更新日期：2011-10-01 00:00:00