Use of monoclonal antibodies to dissect specificity and pathogenesis of antiphospholipid antibodies.

abstract：:Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...

journal_title：Lupus

authors： Gourley IS,Cunnane G,Bresnihan B,FitzGerald O,Bell AL

更新日期：1996-08-01 00:00:00

abstract：:Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In thi...

journal_title：Lupus

authors： Gordon PA,George J,Khamashta MA,Harats D,Hughes G,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：:The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...

journal_title：Lupus

authors： Gladman DD,Urowitz MB

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...

journal_title：Lupus

authors： Zuily S,Rat AC,Regnault V,Kaminsky P,Mismetti P,Ninet J,Baillet N,Magy-Bertrand N,Pasquali JL,Lambert M,Pasquier E,Lorcerie B,Lecompte T,Guillemin F,Wahl D,TAC(I)T investigators.

更新日期：2015-10-01 00:00:00

abstract：:Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...

journal_title：Lupus

authors： Laplante P,Fuentes R,Salem D,Subang R,Gillis MA,Hachem A,Farhat N,Qureshi ST,Fletcher CA,Roubey RA,Merhi Y,Thorin É,Levine JS,Mackman N,Rauch J

更新日期：2016-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...

journal_title：Lupus

authors： Cortes S,Chambers S,Jerónimo A,Isenberg D

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...

journal_title：Lupus

authors： Touma Z,Gladman DD,Ibañez D,Urowitz MB

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...

journal_title：Lupus

authors： Wu SA,Yeh KW,Lee WI,Yao TC,Kuo ML,Huang B,Huang JL

更新日期：2013-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...

journal_title：Lupus

authors： Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

更新日期：2008-05-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...

journal_title：Lupus

authors： Donohoe S,Kingdom JC,Mackie IJ

更新日期：1999-01-01 00:00:00

abstract：:We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...

journal_title：Lupus

authors： Menon S,Snaith ML,Isenberg DA

更新日期：1993-06-01 00:00:00

abstract：:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...

journal_title：Lupus

authors： Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MA

更新日期：2012-04-01 00:00:00

abstract：:In this study, we report the case of a Chinese patient with systemic lupus erythematosus (SLE) who developed neutropenia after treatment by olanzapine for the SLE-related psychiatric symptoms. The relationship between agranulocytosis, SLE and olanzapine is still unknown. Fcγ receptor IIIb (FcγRIIIb) is a low-affinity ...

journal_title：Lupus

authors： Salviati M,Ortona E,Colasanti T,Francia A,Pontecorvo S,Delle Chiaie R

更新日期：2012-01-01 00:00:00

abstract：:Data on the clinical and laboratory profiles of 83 children with SLE have been analysed and compared with data on 187 adults with the disease. The clinical features of childhood SLE are similar to those seen in adults, although clinical and laboratory parameters reflect propensity to a more severe form of the disease ...

journal_title：Lupus

authors： Pande I,Sekharan NG,Kailash S,Uppal SS,Singh RR,Kumar A,Malaviya AN

更新日期：1993-04-01 00:00:00

abstract：:Although osteoporosis has traditionally been considered a disease of women, men also incur substantial bone loss with aging, and elderly men have age-specific hip fracture incidence rates and vertebral fracture prevalence rates that are at least half those in women. Early postmenopausal bone loss (which results in the...

journal_title：Lupus

authors： Khosla S,Melton LJ 3rd,Riggs BL

更新日期：1999-01-01 00:00:00

abstract：:A 24-y-old male who developed necrotic lesions on the lower extremities together with testicular thrombosis necessitating orchiectomy, demonstrated high level IgG anticardiolipin (aCL) associated with acute HIV infection. This is one of the first cases describing a close relationship between viral infection and the cl...

journal_title：Lupus

authors： Leder AN,Flansbaum B,Zandman-Goddard G,Asherson R,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：:Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to inve...

journal_title：Lupus

authors： Mathieu A,Vacca A,Serra A,Cauli A,Piga M,Porru G,Marrosu F,Sanna G,Piga M

更新日期：2010-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial advice against pregna...

journal_title：Lupus

authors： Schreiber K

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...

journal_title：Lupus

authors： Zhang Q,Sun L,Jin L

更新日期：2015-08-01 00:00:00

abstract：:We report a case of a patient with clinical features of progressive supranuclear palsy and raised titres of anticardiolipin antibodies in blood, thrombocytopenia and livedo reticularis on skin. Magnetic resonance imaging of brain and isotope scan of brain were distinctive of vascular disorder. ...

journal_title：Lupus

authors： Reitblat T,Polishchuk I,Dorodnikov E,Aladjem Z,Turiansky L,Zamir D,Kahana E

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina. METHODS:This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint: overall clinical r...

journal_title：Lupus

authors： Babini A,Cappuccio AM,Caprarulo C,Casado G,Eimon A,Figueredo H,García MA,Magri S,Mannucci P,Perez Rodriguez S,Pons-Estel BA,Velozo EJ,Iglesias-Rodriguez M,Streger G

更新日期：2020-10-01 00:00:00

abstract：:Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement ...

journal_title：Lupus

authors： Amigo MC

更新日期：2014-10-01 00:00:00

abstract：:The objective of this study is to investigate the presence of anti-nucleosome (anti-NCS) and anti-chromatin (anti-CRT) antibodies in patients with cutaneous lupus erythematosus (CLE) compared with active and inactive systemic lupus erythematosus (SLE). A total of 154 subjects were evaluated: 54 patients presenting CLE...

journal_title：Lupus

authors： Souza A,da Silva LM,Oliveira FR,Roselino AM,Louzada-Junior P

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...

journal_title：Lupus

authors： da Silva AE,dos Reis-Neto ET,da Silva NP,Sato EI

更新日期：2013-12-01 00:00:00

abstract：:The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding...

journal_title：Lupus

authors： Atsumi T,Khamashta MA,Ames PR,Ichikawa K,Koike T,Hughes GR

更新日期：1997-01-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...

journal_title：Lupus

authors： Piotrowski P,Lianeri M,Mostowska M,Wudarski M,Chwalinska-Sadowska H,Jagodzinski PP

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Children with systemic lupus erythematosus (SLE) have an increased prevalence of kidney disease compared to their adult counterparts. Our goal was to identify potential clinical and laboratory predictors of renal disease. METHODS:We performed a cohort study of incident and prevalent patients with SLE aged...

journal_title：Lupus

authors： Sule SD,Moodalbail DG,Burnham J,Fivush B,Furth SL

更新日期：2015-07-01 00:00:00

abstract：:Objectives Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphis...

journal_title：Lupus

authors： Yusuf JH,Kaliyaperumal D,Jayaraman M,Ramanathan G,Devaraju P

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:To compare and rank currently available pharmacological interventions for the prevention of recurrent miscarriage (RM) in women with antiphospholipid syndrome (APS). METHODS:A search was performed using PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, CNKI, ClinicalTrials....

journal_title：Lupus

authors： Yang Z,Shen X,Zhou C,Wang M,Liu Y,Zhou L

更新日期：2021-01-01 00:00:00