What do we know about the cardiac valve lesion in the antiphospholipid syndrome (APS)?

abstract：:Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...

journal_title：Lupus

authors： Caforio AL,Daliento L,Angelini A,Bottaro S,Vinci A,Dequal G,Tona F,Iliceto S,Thiene G,McKenna WJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....

journal_title：Lupus

authors： Castillo-Martínez D,Marroquín-Fabián E,Lozada-Navarro AC,Mora-Ramírez M,Juárez M,Sánchez-Muñoz F,Vargas-Barrón J,Sandoval J,Amezcua-Guerra LM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：:We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...

journal_title：Lupus

authors： Cooper GS,Parks CG,Treadwell EL,St Clair EW,Gilkeson GS,Cohen PL,Roubey RA,Dooley MA

更新日期：2002-01-01 00:00:00

abstract：:Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...

journal_title：Lupus

authors： Lim KL,Lowe J,Powell RJ

更新日期：1995-04-01 00:00:00

abstract：:The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1998-01-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relati...

journal_title：Lupus

authors： Yoshio T,Okamoto H,Kurasawa K,Dei Y,Hirohata S,Minota S

更新日期：2016-08-01 00:00:00

abstract：:Proteinuria is a well-known risk factor for the progression of renal dysfunction in chronic kidney disease; however, its importance for estimating the prognosis of lupus nephritis requires verification. Korean adult patients with renal biopsy-diagnosed diffuse proliferative lupus nephritis who had undergone three or m...

journal_title：Lupus

authors： Koo HS,Kim S,Chin HJ

更新日期：2016-01-01 00:00:00

abstract：:To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

journal_title：Lupus

authors： Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The objectives of this paper are to compare sexual function and distress in women with systemic lupus erythematosus (SLE) and in healthy controls; to determine the association between disease characteristics, quality of life, psychopathology and sexual function; and to compare sexual function and distress of ...

journal_title：Lupus

authors： García Morales M,Callejas Rubio JI,Peralta-Ramírez MI,Henares Romero LJ,Ríos Fernández R,Camps García MT,Navarrete Navarrete N,Ortego Centeno N

更新日期：2013-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...

journal_title：Lupus

authors： Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00

abstract：:The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease ...

journal_title：Lupus

authors： Cieslinski JZ,Skare TL,Nisihara R,De Messias-Reason IJ,Utiyama SRR

更新日期：2018-03-01 00:00:00

abstract：:Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended p...

journal_title：Lupus

authors： Boumpas DT,Balow JE

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:Thrombosis in the presence of persistently positive tests for antiphospholipid antibodies is termed thrombotic antiphospholipid syndrome (APS). At present, 'standard' secondary thromboprophylaxis in thrombotic APS is treatment with moderate intensity oral anticoagulants for life after a first venous thrombosis and wit...

journal_title：Lupus

authors： Derksen RH,de Groot PG

更新日期：2010-04-01 00:00:00

abstract：:Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...

journal_title：Lupus

authors： Gourley IS,Cunnane G,Bresnihan B,FitzGerald O,Bell AL

更新日期：1996-08-01 00:00:00

abstract：INTRODUCTION:Creatine supplementation has emerged as a promising non-pharmacological therapeutic strategy to counteract muscle dysfunction and low lean mass in a variety of conditions, including in pediatric and rheumatic diseases. The objective of this study was to examine the efficacy and safety of creatine supplemen...

journal_title：Lupus

authors： Hayashi AP,Solis MY,Sapienza MT,Otaduy MC,de Sá Pinto AL,Silva CA,Sallum AM,Pereira RM,Gualano B

更新日期：2014-12-01 00:00:00

abstract：:Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...

journal_title：Lupus

authors： Otsa K,Talli S,Harding P,Parsik E,Esko M,Teepere A,Tammaru M

更新日期：2017-09-01 00:00:00

abstract：:Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...

journal_title：Lupus

authors： Yeter KC,Afkhami M,Brynes RK,Quismorio FP Jr

更新日期：2013-12-01 00:00:00

abstract：:A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...

journal_title：Lupus

authors： Morelli S,Perrone C,Paroli M

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina. METHODS:This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint: overall clinical r...

journal_title：Lupus

authors： Babini A,Cappuccio AM,Caprarulo C,Casado G,Eimon A,Figueredo H,García MA,Magri S,Mannucci P,Perez Rodriguez S,Pons-Estel BA,Velozo EJ,Iglesias-Rodriguez M,Streger G

更新日期：2020-10-01 00:00:00

abstract：:The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...

journal_title：Lupus

authors： Ting W,Stone MS,Racila D,Scofield RH,Sontheimer RD

更新日期：2004-01-01 00:00:00

abstract：:Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...

journal_title：Lupus

authors： Stepanić V,Corusić A,Matković V,Sentić M,Bosnić D,Mahovlić V

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study is to investigate the presence of anti-nucleosome (anti-NCS) and anti-chromatin (anti-CRT) antibodies in patients with cutaneous lupus erythematosus (CLE) compared with active and inactive systemic lupus erythematosus (SLE). A total of 154 subjects were evaluated: 54 patients presenting CLE...

journal_title：Lupus

authors： Souza A,da Silva LM,Oliveira FR,Roselino AM,Louzada-Junior P

更新日期：2009-03-01 00:00:00

abstract：:Concerns regarding the safety and efficacy of immunization in patients with SLE have persisted for over 60 years, despite the increased risk of infection in these patients. There are many anecdotal case reports of SLE induction or exacerbation following immunization, but overall, these events seem to be very rare. Evi...

journal_title：Lupus

authors： O'Neill SG,Isenberg DA

更新日期：2006-01-01 00:00:00

abstract：:The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...

journal_title：Lupus

authors： Catania G,Rossi E,Marmont A

更新日期：2012-05-01 00:00:00

abstract：:Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...

journal_title：Lupus

authors： Jarrett P,Thornley S,Scragg R

更新日期：2016-11-01 00:00:00

abstract：:Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble...

journal_title：Lupus

authors： Cemil BC,Atas H,Canpolat F,Akca Y,Sasmaz R

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Anti-RNP autoantibodies occur either in mixed connective tissue disease (MCTD) (with a frequently favorable prognosis), or in systemic lupus erythematosus (SLE) cases with aggressive major organ disease. It is uncertain how to assess for the risk of severe disease in anti-RNP + patients. METHODS:Following...

journal_title：Lupus

authors： Carpintero MF,Martinez L,Fernandez I,Romero AC,Mejia C,Zang YJ,Hoffman RW,Greidinger EL

更新日期：2015-09-01 00:00:00