Abstract:
:Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended period of time required to reach them. More recently, discussions have focused on composite outcome measures, such as remission and relapse, as well as measures of health-related quality of life, general lupus activity and cumulative damage indexes. We review the strengths and weaknesses of several outcome criteria, and we propose criteria for both small pilot studies and large definitive trials.
journal_name
Lupusjournal_title
Lupusauthors
Boumpas DT,Balow JEdoi
10.1191/096120398678920758subject
Has Abstractpub_date
1998-01-01 00:00:00pages
622-9issue
9eissn
0961-2033issn
1477-0962journal_volume
7pub_type
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