The French-Canadian validation of a disease-specific, patient-reported outcome measure for lupus.

abstract：:Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...

journal_title：Lupus

authors： Silvestris F,Grinello D,Tucci M,Cafforio P,Dammacco F

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends ...

journal_title：Lupus

authors： Hannah J,Galloway J,Kaul A

更新日期：2019-06-01 00:00:00

abstract：:Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...

journal_title：Lupus

authors： Midgley A,Mayer K,Edwards SW,Beresford MW

更新日期：2011-01-01 00:00:00

abstract：:Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupu...

journal_title：Lupus

authors： Di Matteo A,Satulu I,Di Carlo M,Lato V,Filippucci E,Grassi W

更新日期：2017-03-01 00:00:00

abstract：:Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythem...

journal_title：Lupus

authors： Khairullah S,Jasmin R,Yahya F,Cheah TE,Ng CT,Sockalingam S

更新日期：2013-08-01 00:00:00

abstract：:The aim of this study was to describe the clinical course of patients with lupus nephritis (LN) who attain a sustained remission (SR) and identify predictors of SR. A retrospective study of patients with biopsy-proven LN were followed for up to 10 years. SR was defined as normal renal function, urine protein <0.5g/day...

journal_title：Lupus

authors： Barber CE,Geldenhuys L,Hanly JG

更新日期：2006-01-01 00:00:00

abstract：:The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...

journal_title：Lupus

authors： Malik M,Arora P,Sachdeva R,Sharma L,Ramachandran VG,Pal R

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse autoantibodies' titres modulation during belimumab treatment in 50 patients with systemic lupus erythematosus (SLE). METHODS:Sera were collected at belimumab start (T0) and every six months until the 24th month. Disease activity index (SLEDAI-2K) was analysed at eve...

journal_title：Lupus

authors： Cavazzana I,Kumar R,Pozzari C,Ottaviani R,Fredi M,Piantoni S,Andreoli L,Tincani A,Franceschini F

更新日期：2019-08-01 00:00:00

abstract：:In order to ascertain the incidence of monoclonal gammopathy (MG) in systemic lupus erythematosus (SLE), 120 SLE patients were evaluated. Four patients (3.3%), two of whom were under 50 years of age, were found to have a monoclonal immunoglobulin in their serum. Our data agree with the previous literature in demonstra...

journal_title：Lupus

authors： Porcel JM,Ordi J,Tolosa C,Selva A,Castro-Salomo A,Vilardell M

更新日期：1992-08-01 00:00:00

abstract：:Sera from healthy individuals, relatives of lupus patients, and lupus patients with active disease and in remission were screened for IgG and IgM antibodies to ssDNA and dsDNA. The serum samples were also separated into IgG and IgM fractions which were screened for DNA reactivity at dilutions equivalent to those used ...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1996-12-01 00:00:00

abstract：:Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...

journal_title：Lupus

authors： Wei CC,Lin CL,Tsai JD,Shen TC,Sung FC

更新日期：2014-12-01 00:00:00

abstract：:Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended p...

journal_title：Lupus

authors： Boumpas DT,Balow JE

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relati...

journal_title：Lupus

authors： Yoshio T,Okamoto H,Kurasawa K,Dei Y,Hirohata S,Minota S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The objective of this report is to assess the presence and viral load of JC polyomavirus (JCV) DNA in cerebrospinal fluid (CSF) and plasma from neuropsychiatric systemic lupus erythematosus (NPSLE) patients in comparison to controls and to investigate if different types of immunosuppressive treatments were co...

journal_title：Lupus

authors： Iacobaeus E,Hopia L,Khademi M,Lundén M,Hammarin AL,Svenungsson E,Andersson M

更新日期：2013-03-01 00:00:00

abstract：:Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...

journal_title：Lupus

authors： Caforio AL,Daliento L,Angelini A,Bottaro S,Vinci A,Dequal G,Tona F,Iliceto S,Thiene G,McKenna WJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...

journal_title：Lupus

authors： Zhang Q,Sun L,Jin L

更新日期：2015-08-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a rare, deadly demyelinating disease of the central nervous system, which is caused by a reactivation of the DNA polyomavirus JC and occurs in immunosuppressed individuals. So far, only 25 cases have been described in patients with SLE and none survived without antiv...

journal_title：Lupus

authors： Nived O,Bengtsson AA,Jönsen A,Sturfelt G

更新日期：2008-11-01 00:00:00

abstract：:A 28-year-old woman with systemic lupus erythematosus (SLE) suffered recent onset fever, headache, encephalopathy followed by severe, repeated generalized seizures. Investigations revealed limbic encephalitis. Tests for Herpes simplex encephalitis and paraneoplastic encephalomyelitis were negative. High titers anti-ri...

journal_title：Lupus

authors： Stübgen JP

更新日期：1998-01-01 00:00:00

abstract：:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...

journal_title：Lupus

authors： Hasegawa K,Hayashi T

更新日期：2003-01-01 00:00:00

abstract：:Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the...

journal_title：Lupus

authors： Farhey Y,Hess EV

更新日期：1997-01-01 00:00:00

abstract：:In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...

journal_title：Lupus

authors： Dinu AR,Merrill JT,Shen C,Antonov IV,Myones BL,Lahita RG

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...

journal_title：Lupus

authors： Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

更新日期：2004-01-01 00:00:00

abstract：:Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...

journal_title：Lupus

authors： Lee YH,Jung JH,Seo YH,Kim JH,Choi SJ,Ji JD,Song GG

更新日期：2017-03-01 00:00:00

abstract：:Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...

journal_title：Lupus

authors： Schnitz WM,Lister KA,McCarty GA

更新日期：1992-05-01 00:00:00

abstract：:Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...

journal_title：Lupus

authors： Ricarte IF,Dutra LA,Abrantes FF,Toso FF,Barsottini OGP,Silva GS,de Souza AWS,Andrade D

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between antimalarials (AM) and elevated muscle enzymes in systemic lupus erythematosus (SLE). PATIENTSMETHODS:325 lupus patients with abnormal creatine phosphokinase (CPK) for at least two consecutive clinic visits were enrolled; 54 patients on statins/fibrates (n = 43) and/or...

journal_title：Lupus

authors： Tselios K,Gladman DD,Su J,Urowitz MB

更新日期：2016-04-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specifi...

journal_title：Lupus

authors： Tandon A,Anupam K,Kaushal J,Gautam P,Sharma A,Bhatnagar A

更新日期：2020-12-01 00:00:00

abstract：:A 22-year-old female with history of systemic lupus erythematosus (SLE) was referred for evaluation of decreased visual acuity in her right eye. Her best-corrected visual acuity (BCVA) at the time of presentation was 20/160. Widespread cotton wool spots and macular edema were seen on biomicroscopy. Fluorescein angiogr...

journal_title：Lupus

authors： Jeon S,Lee WK

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Environmental factors appear to play a role in the pathogenesis of lupus erythematosus (LE). OBJECTIVE:To determine the association between cigarette smoking and various types of cutaneous LE. DESIGN:Retrospective descriptive study at a dermatology clinic of a tertiary referral hospital. METHODS:All patie...

journal_title：Lupus

authors： Böckle BC,Sepp NT

更新日期：2015-06-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00