The lupus patient traveller: a guide to the rheumatologist.

abstract：:'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to...

journal_title：Lupus

authors： Kandiah DA,Krilis SA

更新日期：1996-04-01 00:00:00

abstract：:Objectives Avascular necrosis (AVN) is one of the most common causes of organ damage in patients with systemic lupus erythematosus (SLE) and often causes serious physical disability. The aims of this study were to investigate clinical risk factors associated with symptomatic AVN and to analyze their synergistic effect...

journal_title：Lupus

authors： Kwon HH,Bang SY,Won S,Park Y,Yi JH,Joo YB,Lee HS,Bae SC

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...

journal_title：Lupus

authors： Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

更新日期：2020-01-01 00:00:00

abstract：:We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...

journal_title：Lupus

authors： Blanco F,Longhurst C,Watts R,Kalsi J,Wiloch HW,Youinou P,Latchman DS,Isenberg DA

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:Creatine supplementation has emerged as a promising non-pharmacological therapeutic strategy to counteract muscle dysfunction and low lean mass in a variety of conditions, including in pediatric and rheumatic diseases. The objective of this study was to examine the efficacy and safety of creatine supplemen...

journal_title：Lupus

authors： Hayashi AP,Solis MY,Sapienza MT,Otaduy MC,de Sá Pinto AL,Silva CA,Sallum AM,Pereira RM,Gualano B

更新日期：2014-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...

journal_title：Lupus

authors： Delfani P,Sturfelt G,Gullstrand B,Carlsson A,Kassandra M,Borrebaeck CA,Bengtsson AA,Wingren C

更新日期：2017-04-01 00:00:00

abstract：:Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...

journal_title：Lupus

authors： Anam K,Amare M,Naik S,Szabo KA,Davis TA

更新日期：2009-04-01 00:00:00

abstract：:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...

journal_title：Lupus

authors： La Cava A

更新日期：2008-05-01 00:00:00

abstract：:Intestinal pseudo-obstruction (IpsO) occurs in a small subgroup of patients with systemic lupus erythematosus (SLE), and has been under-recognized. The etiology and mechanisms are unclear. Herein, we report two cases. In case 1, IpsO occurred as the complication in a previously diagnosed SLE patient. In case 2, IpsO w...

journal_title：Lupus

authors： Zhang J,Fang M,Wang Y,Mao J,Sun X

更新日期：2011-10-01 00:00:00

abstract：:Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. C...

journal_title：Lupus

authors： Nelson JL

更新日期：2002-01-01 00:00:00

abstract：:We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...

journal_title：Lupus

authors： Baca V,Catalán T,Villasís-Keever M,Ramón G,Morales AM,Rodríguez-Leyva F

更新日期：2006-01-01 00:00:00

abstract：:Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...

journal_title：Lupus

authors： Choi MY,Barber MR,Barber CE,Clarke AE,Fritzler MJ

更新日期：2016-07-01 00:00:00

abstract：:The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...

journal_title：Lupus

authors： Blank M,Aron-Maor A,Shoenfeld Y

更新日期：2005-01-01 00:00:00

abstract：:We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...

journal_title：Lupus

authors： Daïkha-Dahmane F,Bault JP,Molina-Gomes D,Hillion D,Ville Y

更新日期：2005-01-01 00:00:00

abstract：:This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...

journal_title：Lupus

authors： Boffa MC,Aurousseau MH,Lachassinne E,Dauphin H,Fain O,Le Toumelin P,Uzan M,Piette JC,Derenne S,Boinot C,Avcin T,Motta M,Faden D,Tincani A

更新日期：2004-01-01 00:00:00

abstract：:Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...

journal_title：Lupus

authors： Tripodi A,Chantarangkul V,Pengo V

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...

journal_title：Lupus

authors： da Silva AE,dos Reis-Neto ET,da Silva NP,Sato EI

更新日期：2013-12-01 00:00:00

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...

journal_title：Lupus

authors： Morelli S,Perrone C,Paroli M

更新日期：1998-01-01 00:00:00

abstract：:Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...

journal_title：Lupus

authors： Gourley IS,Cunnane G,Bresnihan B,FitzGerald O,Bell AL

更新日期：1996-08-01 00:00:00

abstract：:The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar flu...

journal_title：Lupus

authors： Rojas-Serrano J,Pedroza J,Regalado J,Robledo J,Reyes E,Sifuentes-Osornio J,Flores-Suárez LF

更新日期：2008-04-01 00:00:00

abstract：:Vaccines have undoubtedly brought overwhelming benefits to mankind and are considered safe and effective. Nevertheless, they can occasionally stimulate autoantibody production or even a recently defined syndrome known as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is scarce data regarding autoi...

journal_title：Lupus

authors： Perdan-Pirkmajer K,Thallinger GG,Snoj N,Čučnik S,Žigon P,Kveder T,Logar D,Praprotnik S,Tomšič M,Sodin-Semrl S,Ambrožič A

更新日期：2012-02-01 00:00:00

abstract：:Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...

journal_title：Lupus

authors： Lee YH,Jung JH,Seo YH,Kim JH,Choi SJ,Ji JD,Song GG

更新日期：2017-03-01 00:00:00

abstract：:Tubulointerstitial injury is found frequently in lupus nephritis. Immune complex deposits can occur in the tubular basement membranes (TBMs), although its significance in lupus nephritis patients remains unclear. This study assessed the clinical and prognostic features of lupus nephritis patients with TBM deposits in ...

journal_title：Lupus

authors： Wang H,Xu J,Zhang X,Ren YL,Cheng M,Guo ZL,Zhang JC,Cheng H,Xing GL,Wang SX,Yu F,Zhao MH

更新日期：2018-04-01 00:00:00

abstract：:XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...

journal_title：Lupus

authors： Lin YJ,Wan L,Huang CM,Chen SY,Huang YC,Lai CH,Lin WY,Liu HP,Wu YS,Chen CM,Tsai YH,Tsai CH,Sheu JJ,Tsai FJ

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:For patients with chronic illnesses the global burden of illness is a crucial health measure hitherto neglected in research studies and clinical practice. We tested the application and validity of PRISM (Pictorial Representation of Illness and Self-Measure), a novel visual method for assessing the burden of i...

journal_title：Lupus

authors： Büchi S,Villiger P,Kauer Y,Klaghofer R,Sensky T,Stoll T

更新日期：2000-01-01 00:00:00

abstract：:Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...

journal_title：Lupus

authors： Zoma A

更新日期：2004-01-01 00:00:00

abstract：:Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ...

journal_title：Lupus

authors： de Groot K,Gross WL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Current non-invasive methods of assessing disease activity in systemic lupus erythematosus (SLE) are of limited sensitivity and specificity. Testing includes acute phase markers, autoantibodies and complement levels. Although measurements of dsDNA antibodies and complement C3/C4 levels are routine, they rema...

journal_title：Lupus

authors： Adhya Z,El Anbari M,Anwar S,Mortimer A,Marr N,Karim MY

更新日期：2019-05-01 00:00:00