Tubular basement membrane immune complex deposition is associated with activity and progression of lupus nephritis: a large multicenter Chinese study.

abstract：:The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...

journal_title：Lupus

authors： Hanly JG

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...

journal_title：Lupus

authors： Zuily S,Rat AC,Regnault V,Kaminsky P,Mismetti P,Ninet J,Baillet N,Magy-Bertrand N,Pasquali JL,Lambert M,Pasquier E,Lorcerie B,Lecompte T,Guillemin F,Wahl D,TAC(I)T investigators.

更新日期：2015-10-01 00:00:00

abstract：:Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...

journal_title：Lupus

authors： Fraenkel L,Bogardus ST Jr,Wittink DR

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：:Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble...

journal_title：Lupus

authors： Cemil BC,Atas H,Canpolat F,Akca Y,Sasmaz R

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the occurrence of idiopathic intracranial hypertension (IIH) in patients with systemic lupus erythematosus (SLE) and to describe the manifestations, treatments and outcomes in these patients. METHODS:We reviewed the medical records of 1084 patients with SLE followed up from January 1997 to June 2...

journal_title：Lupus

authors： Kim JM,Kwok SK,Ju JH,Kim HY,Park SH

更新日期：2012-04-01 00:00:00

abstract：:Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...

journal_title：Lupus

authors： Shaharir SS,Osman SS,Md Rani SA,Sakthiswary R,Said MSM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...

journal_title：Lupus

authors： Adhikari T,Piatti A,Luggen M

更新日期：2011-10-01 00:00:00

abstract：:Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...

journal_title：Lupus

authors： Tselios K,Deeb M,Gladman DD,Harvey P,Urowitz MB

更新日期：2018-04-01 00:00:00

abstract：:The F(1) progeny of the (SWR × NZB) cross develop a lupus-like disease with high serum titers of autoantibodies, and increased frequency and severity of immune complex-mediated glomerulonephritis in females. In previous work, we found that an idiotypic peptide corresponding to aa62-73 (p62-73) of the heavy chain varia...

journal_title：Lupus

authors： Nyland JF,Stoll ML,Jiang F,Feng F,Gavalchin J

更新日期：2012-12-01 00:00:00

abstract：:The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...

journal_title：Lupus

authors： Lui SL,Lam MF,Tse KC,Lo WK

更新日期：2002-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a suggested genetic basis. The newly identified human programmed cell death 1 gene could be associated with SLE susceptibility. We aimed to investigate the association between programmed cell death 1 polymorphism (PD1.3G/A (rs11568821) and PD1...

journal_title：Lupus

authors： Abo El-Khair SM,Sameer W,Awadallah N,Shaalan D

更新日期：2019-10-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...

journal_title：Lupus

authors： Meijer C,Huysen V,Smeenk RT,Swaak AJ

更新日期：1993-12-01 00:00:00

abstract：:The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...

journal_title：Lupus

authors： Al-Mayouf SM,Al Sonbul A

更新日期：2006-01-01 00:00:00

abstract：:With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will undertake such travel. In this context, the lupus patient presents a great challenge to the rheumatologist. However, the demand for such information by patient...

journal_title：Lupus

authors： Oliveira DS,Hillal JPD,Cordova DDP,de Araujo DB

更新日期：2019-12-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...

journal_title：Lupus

authors： Donohoe S,Kingdom JC,Mackie IJ

更新日期：1999-01-01 00:00:00

abstract：:The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...

journal_title：Lupus

authors： Malik M,Arora P,Sachdeva R,Sharma L,Ramachandran VG,Pal R

更新日期：2016-06-01 00:00:00

abstract：:We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had fail...

journal_title：Lupus

authors： Lee T,Oh KH,Joo KW,Kim YS,Ahn C,Han JS,Kim S,Chin HJ

更新日期：2010-07-01 00:00:00

abstract：:Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...

journal_title：Lupus

authors： Schnitz WM,Lister KA,McCarty GA

更新日期：1992-05-01 00:00:00

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00

abstract：:Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...

journal_title：Lupus

authors： Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen W

更新日期：2020-04-01 00:00:00

abstract：:Only recently Bartonella species have been recognized as important human pathogens. Cat scratch disease (CSD), caused by infection with Bartonella henselae, shows a steady increase in the number of cases throughout the world. We report a case of an 18-year-old woman with systemic lupus erythematosus (SLE) who presente...

journal_title：Lupus

authors： Gaubitz M,Herrmann M,Shahin M,Schotte H,Willeke P,Domschke W

更新日期：2001-01-01 00:00:00

abstract：:In order to ascertain the incidence of monoclonal gammopathy (MG) in systemic lupus erythematosus (SLE), 120 SLE patients were evaluated. Four patients (3.3%), two of whom were under 50 years of age, were found to have a monoclonal immunoglobulin in their serum. Our data agree with the previous literature in demonstra...

journal_title：Lupus

authors： Porcel JM,Ordi J,Tolosa C,Selva A,Castro-Salomo A,Vilardell M

更新日期：1992-08-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...

journal_title：Lupus

authors： Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...

journal_title：Lupus

authors： Mulliez SM,De Keyser F,Verbist C,Vantilborgh A,Wijns W,Beukinga I,Devreese KM

更新日期：2015-06-01 00:00:00

abstract：:Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...

journal_title：Lupus

authors： Jarrett P,Thornley S,Scragg R

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...

journal_title：Lupus

authors： Ulcova-Gallova Z

更新日期：2012-06-01 00:00:00

abstract：:The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...

journal_title：Lupus

authors： Gladman DD,Urowitz MB

更新日期：1999-01-01 00:00:00

abstract：:We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...

journal_title：Lupus

authors： Castellino G,Govoni M,Lo Monaco A,Montecucco C,Colombo F,Trotta F

更新日期：2004-01-01 00:00:00

abstract：:We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of ...

journal_title：Lupus

authors： Hamasaki K,Mimura T,Kanda H,Morino N,Yazaki Y,Nojima Y

更新日期：1997-01-01 00:00:00