Abstract:
:We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had failed to respond to sufficient intravenous cyclophosphamide therapy with proteinuria of >or=1 g/day and active urinary sediments. Tacrolimus (0.1 mg/kg/day) was administered for 1 year with adjusting drug level (4-10 microg/l). The mean serum creatinine level and spot urine protein creatinine ratio (UPCR) at baseline were 1.39 mg/dl and 2.27, respectively. After the treatment, proteinuria reduced significantly from median UPCR value of 2.19 (range, 1.19-3.34) to 0.44 (range, 0.12-2.13) (p < 0.05). Seven (78%) of the nine patients showed a complete clinical response, which was defined as stabilization in the disease-activity markers and serum creatinine level with reduction of >or=50% in UPCR; two patients showed complete remission with UPCR <0.2. One patient showed treatment failure because of the disease progression. No serious adverse effects were observed during the study. This study demonstrates that tacrolimus can show a significant therapeutic response in cases that are refractory to the standard regimen for diffuse proliferative lupus nephritis.
journal_name
Lupusjournal_title
Lupusauthors
Lee T,Oh KH,Joo KW,Kim YS,Ahn C,Han JS,Kim S,Chin HJdoi
10.1177/0961203310366573subject
Has Abstractpub_date
2010-07-01 00:00:00pages
974-80issue
8eissn
0961-2033issn
1477-0962pii
19/8/974journal_volume
19pub_type
临床试验,杂志文章相关文献
LUPUS文献大全abstract::Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316676384
更新日期:2017-06-01 00:00:00
abstract::The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330607192
更新日期:2006-01-01 00:00:00
abstract::A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that in...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313499419
更新日期:2014-05-01 00:00:00
abstract::The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339400300408
更新日期:1994-08-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract::In vitro data showed that immunoglobulin G (IgG) from lupus nephritis (LN) patients could bind to proximal renal tubular epithelial cells (PTEC), but the clinical relevance of such binding remained unclear. Binding of IgG and subclasses to PTEC was measured by cellular ELISA (expressed as OD index) in 189 serial serum...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315598018
更新日期:2016-01-01 00:00:00
abstract::Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant stu...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203320909432
更新日期:2020-04-01 00:00:00
abstract::The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318801520
更新日期:2018-12-01 00:00:00
abstract::Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316642310
更新日期:2016-10-01 00:00:00
abstract::Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...
journal_title:Lupus
pub_type: 共识发展会议,杂志文章,评审
doi:10.1191/0961203303lu392oa
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320923393
更新日期:2020-06-01 00:00:00
abstract::Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310382128
更新日期:2011-01-01 00:00:00
abstract::This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1089oa
更新日期:2004-01-01 00:00:00
abstract::To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308093458
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319828822
更新日期:2019-03-01 00:00:00
abstract::The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu096cr
更新日期:2002-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669240
更新日期:2017-04-01 00:00:00
abstract::High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311399606
更新日期:2011-08-01 00:00:00
abstract::Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203316682101
更新日期:2017-07-01 00:00:00
abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2037sa
更新日期:2004-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2299oa
更新日期:2006-01-01 00:00:00
abstract::The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis- (PM) and dermatomyositis- (DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2158oa
更新日期:2005-01-01 00:00:00
abstract::Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308099242
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319828523
更新日期:2019-03-01 00:00:00
abstract::Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, wh...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320974091
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203319862610
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311411598
更新日期:2011-10-01 00:00:00
abstract::Systemic lupus erythematosus may present with renal manifestations that frequently are difficult to categorize and lupus nephritis is an important predictor of poor outcome. The type and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrotic syndrome appear with increased risk of e...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309358187
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315580871
更新日期:2015-10-01 00:00:00
abstract::There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2061oa
更新日期:2005-01-01 00:00:00