Effect of pericardial effusion on outcomes in children admitted with systemic lupus erythematosus: a multicenter retrospective cohort study from the United States.

Abstract:

OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients were included if they were admitted to a PHIS participating hospital from 2004 to 2015 with a diagnosis of SLE and age ≤18 years. Children with congenital heart disease or who had undergone heart surgery were excluded. PCE was the primary predictor variable; multivariable analysis was used to evaluate the effect of PCE on the following outcomes: mortality, length of stay (LOS), and readmission within 30 days. RESULTS:There were 5679 admissions, of which 705 (12.4%) had PCE. Median age at admission was 15 years (interquartile range: 13-17). There were no significant differences for age or sex between patients admitted either with or without PCE. A significantly higher percentage of children in the PCE group were black compared with those without PCE (43% vs. 31%, p < 0.001). In multivariable analysis, the odds of a black patient having PCE were 1.7 higher than non-black patients ( p < 0.001). In-hospital mortality was 2.5 times higher in children with PCE compared with those without PCE ( p = 0.027). Those with PCE also had 1.5 greater odds of readmission within 30 days ( p < 0.001). PCE was not associated with increased LOS (0.99, p = 0.753). CONCLUSION:PCE is common in admissions of children with SLE. There are disproportionately more black patients with SLE affected by PCE than non-black. PCE is associated with significantly higher mortality and rates of readmission.

journal_name

Lupus

journal_title

Lupus

authors

Dalby ST,Tang X,Daily JA,Sukumaran S,Collins RT,Bolin EH

doi

10.1177/0961203319828523

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

389-395

issue

3

eissn

0961-2033

issn

1477-0962

journal_volume

28

pub_type

杂志文章,多中心研究

相关文献

LUPUS文献大全
  • Impact of hypertension and hyperhomocysteinemia on arterial thrombosis in primary antiphospholipid syndrome.

    abstract::The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203307081847

    authors: de Souza AW,Silva NP,de Carvalho JF,D'Almeida V,Noguti MA,Sato EI

    更新日期:2007-01-01 00:00:00

  • The role of anti-malarials in rheumatoid arthritis--the American experience.

    abstract::Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:

    authors: Khraishi MM,Singh G

    更新日期:1996-06-01 00:00:00

  • Bilateral choroidopathy in systemic lupus erythematosus.

    abstract::We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1177/0961203311398510

    authors: Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

    更新日期:2011-10-01 00:00:00

  • The SLICC/ACR damage index: progress report and experience in the field.

    abstract::The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/096120399680411335

    authors: Gladman DD,Urowitz MB

    更新日期:1999-01-01 00:00:00

  • Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus and the spectrum of the acute syndrome of apoptotic pan-epidermolysis (ASAP): a case report, concept review and proposal for new classification of lupus erythematosus vesiculobullous skin

    abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1191/0961203304lu2037sa

    authors: Ting W,Stone MS,Racila D,Scofield RH,Sontheimer RD

    更新日期:2004-01-01 00:00:00

  • Advanced MRI techniques: biomarkers in neuropsychiatric lupus.

    abstract::Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients witho...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203316674820

    authors: Sarbu N,Toledano P,Calvo A,Roura E,Sarbu MI,Espinosa G,Lladó X,Cervera R,Bargalló N

    更新日期:2017-04-01 00:00:00

  • IL-6, IL-8, IP-10, MCP-1 and G-CSF are significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosus.

    abstract:OBJECTIVE:To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relati...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203316629556

    authors: Yoshio T,Okamoto H,Kurasawa K,Dei Y,Hirohata S,Minota S

    更新日期:2016-08-01 00:00:00

  • Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome.

    abstract:OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203312444172

    authors: De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

    更新日期:2012-06-01 00:00:00

  • Therapeutic drug monitoring of mycophenolate mofetil for the treatment of severely active lupus nephritis.

    abstract:BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...

    journal_title:Lupus

    pub_type: 临床试验,杂志文章

    doi:10.1177/0961203313486949

    authors: Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

    更新日期:2013-06-01 00:00:00

  • Cytomegalovirus infection in Systemic Lupus Erythematosus: report of four cases challenging the management of the disease, and literature review.

    abstract::Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203319825570

    authors: Sebastiani GD,Iuliano A,Canofari C,Bracci M

    更新日期:2019-03-01 00:00:00

  • Prothrombin as cofactor for antiphospholipids.

    abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1177/096120339800700209

    authors: Galli M,Barbui T

    更新日期:1998-01-01 00:00:00

  • Why not work on T and NK cells in the Kunkel laboratory?

    abstract::Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

    journal_title:Lupus

    pub_type: 传,历史文章,杂志文章

    doi:10.1191/0961203303lu355xx

    authors: Kabelitz D

    更新日期:2003-01-01 00:00:00

  • Risk-attitude and patient treatment preferences.

    abstract::Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/0961203303lu371oa

    authors: Fraenkel L,Bogardus ST Jr,Wittink DR

    更新日期:2003-01-01 00:00:00

  • Development of systemic lupus erythematosus in a rheumatoid arthritis patient with anti-ribosomal P protein antibody.

    abstract::We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/096120339700600910

    authors: Hamasaki K,Mimura T,Kanda H,Morino N,Yazaki Y,Nojima Y

    更新日期:1997-01-01 00:00:00

  • Idiopathic intracranial hypertension as a significant cause of intractable headache in patients with systemic lupus erythematosus: a 15-year experience.

    abstract:OBJECTIVE:To evaluate the occurrence of idiopathic intracranial hypertension (IIH) in patients with systemic lupus erythematosus (SLE) and to describe the manifestations, treatments and outcomes in these patients. METHODS:We reviewed the medical records of 1084 patients with SLE followed up from January 1997 to June 2...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203311435267

    authors: Kim JM,Kwok SK,Ju JH,Kim HY,Park SH

    更新日期:2012-04-01 00:00:00

  • Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis.

    abstract:BACKGROUND:Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2R antibodies in a large cohort of p...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203319828521

    authors: Garcia-Vives E,Solé C,Moliné T,Alvarez-Rios AM,Vidal M,Agraz I,Ordi-Ros J,Cortés-Hernández J

    更新日期:2019-03-01 00:00:00

  • SLE presenting as multiple hemorrhagic complications.

    abstract::A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203315573853

    authors: Abdulla MC,Alungal J,Hashim S,Ali MM,Musambil M

    更新日期:2015-09-01 00:00:00

  • Altered hippocampal functional connectivity in primary Sjögren syndrome: a resting-state fMRI study.

    abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203320908936

    authors: Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen W

    更新日期:2020-04-01 00:00:00

  • Pathogenesis of the antiphospholipid antibody syndrome.

    abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1177/096120339600500514

    authors: Lockshin MD

    更新日期:1996-10-01 00:00:00

  • Update on therapy--thalidomide in the treatment of lupus.

    abstract::Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1191/096120301677213822

    authors: Karim MY,Ruiz-Irastorza G,Khamashta MA,Hughes GR

    更新日期:2001-01-01 00:00:00

  • Immunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus.

    abstract::Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex-histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203320928419

    authors: Liu F,Chen H,Chen T,Lau CS,Yu FX,Chen K,Chen HP,Pan RS,Chan GC,Zhang XY,Nie YJ

    更新日期:2020-07-01 00:00:00

  • Chronic or recurrent headache in patients with systemic lupus erythematosus: a case control study.

    abstract::Controversy exists concerning the prevalence of headache in systemic lupus erythematosus (SLE) and its importance as a neuropsychiatric manifestation, especially when it occurs independently of disease activity and with the typical characteristics of primary chronic headache. Most reports to date have either studied b...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/096120399678847443

    authors: Fernández-Nebro A,Palacios-Muñoz R,Gordillo J,Abarca-Costalago M,De Haro-Liger M,Rodríguez-Andreu J,González-Santos P

    更新日期:1999-01-01 00:00:00

  • Tacrolimus is an alternative therapeutic option for the treatment of refractory lupus nephritis.

    abstract::We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had fail...

    journal_title:Lupus

    pub_type: 临床试验,杂志文章

    doi:10.1177/0961203310366573

    authors: Lee T,Oh KH,Joo KW,Kim YS,Ahn C,Han JS,Kim S,Chin HJ

    更新日期:2010-07-01 00:00:00

  • Ferritin in the antiphospholipid syndrome and its catastrophic variant (cAPS).

    abstract:BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203313504633

    authors: Agmon-Levin N,Rosário C,Katz BS,Zandman-Goddard G,Meroni P,Cervera R,Stojanovich L,Blank M,Pierangeli S,Praprotnik S,Meis Ed,Seguro LP,Ruffatti A,Pengo V,Tincani A,Doria A,Shoenfeld Y

    更新日期:2013-11-01 00:00:00

  • Estrogen does not regulate CD154 mRNA stability in systemic lupus erythematosus T cells.

    abstract::Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203306071314

    authors: Li X,Rider V,Kimler BF,Abdou NI

    更新日期:2006-01-01 00:00:00

  • Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.

    abstract::To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203308089443

    authors: Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

    更新日期:2008-09-01 00:00:00

  • High-dose cyclophosphamide for severe systemic lupus erythematosus.

    abstract::Cytotoxic therapy is a cornerstone for patients with severe systemic lupus erythematosus (SLE). High-dose cyclophosphamide, 200 mg/kg, can induce a complete remission without the need for stem cell rescue in patients with autoimmune illnesses. Here we report on our first four patients treated for severe SLE with this ...

    journal_title:Lupus

    pub_type: 临床试验,杂志文章

    doi:10.1191/0961203302lu229oa

    authors: Gladstone DE,Prestrud AA,Pradhan A,Styler MJ,Topolsky DL,Crilley PA,Hoch S,Huppert A,Brodsky I

    更新日期:2002-01-01 00:00:00

  • Repeated miscarriages in patients with antiphospholipid syndrome and subjected to in vitro fertilization: the importance of preimplantation genetic diagnosis.

    abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203312442581

    authors: Ulcova-Gallova Z

    更新日期:2012-06-01 00:00:00

  • Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

    abstract::C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203307083279

    authors: Li SJ,Liu ZH,Zen CH,Wang QW,Wang Y,Li LS

    更新日期:2007-01-01 00:00:00

  • Serum level of anti-α-enolase antibody in untreated systemic lupus erythematosus patients correlates with 24-hour urine protein and D-dimer.

    abstract::Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203317721752

    authors: Li M,Li J,Wang J,Li Y,Yang P

    更新日期:2018-01-01 00:00:00