Abstract:
:There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models of lupus which have reported improved renal function and animal survival compared to placebo. This report reviews the data regarding MMF therapy in murine lupus models, and describes the initial anecdotal experience with MMF in human lupus, especially in patients with glomerulonephritis who were unresponsive to corticosteroids and cyclophosphamide, or who had unacceptable toxicity on this standard of care regimen. The results of several nonblinded, controlled clinical trials are also described, in which MMF was compared to intravenous or oral cyclophosphamide in patients with lupus nephritis. MMF was found to be well tolerated, with most studies showing fewer infections than that associated with cyclophosphamide. Efficacy of MMF was at least equivalent to cyclophosphamide, and therefore appears to provide an alternative as a standard of care for induction and maintenance treatment of lupus nephritis.
journal_name
Lupusjournal_title
Lupusauthors
Ginzler EM,Aranow Cdoi
10.1191/0961203305lu2061oasubject
Has Abstractpub_date
2005-01-01 00:00:00pages
59-64issue
1eissn
0961-2033issn
1477-0962journal_volume
14pub_type
杂志文章,评审相关文献
LUPUS文献大全abstract:OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320928421
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316629556
更新日期:2016-08-01 00:00:00
abstract::We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2312oa
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to examine some solid tumors incidence in patients with systemic lupus erythematosus (SLE) derived from population-based cohort studies by means of meta-analysis. METHODS:Relevant electronic databases were searched for studies characterizing the associated risk of overall malig...
journal_title:Lupus
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0961203313520060
更新日期:2014-03-01 00:00:00
abstract::Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu371oa
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). METHODS:A series of meta-analyses were conducted to test for association between the CD40 ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203315583543
更新日期:2015-10-01 00:00:00
abstract::We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300105
更新日期:1994-02-01 00:00:00
abstract::We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu2045cr
更新日期:2005-01-01 00:00:00
abstract::Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313517150
更新日期:2014-02-01 00:00:00
abstract::Autoantibodies to DNA were discovered over 40 years ago following the discovery a few years earlier of the 'LE' cell phenomenon by Hargraves and colleagues in 1948. These investigators noted that, when leucocytes were incubated with serum from lupus patients, changes in the nucleus could be seen together with phagocyt...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu317oa
更新日期:2002-01-01 00:00:00
abstract::Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315603146
更新日期:2016-02-01 00:00:00
abstract::Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301677213822
更新日期:2001-01-01 00:00:00
abstract::Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant stu...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203320909432
更新日期:2020-04-01 00:00:00
abstract::The potential of oral treatment with AVEMAR (AVEMAR), a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301682430203
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320950019
更新日期:2020-11-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071314
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to evaluate whether the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of proliferative lupus nephritis (LN) have a distinct baseline presentation, short-term response to immunosuppression (IS) and long-term prognosis. METHODS:Ninety-eig...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313514623
更新日期:2014-02-01 00:00:00
abstract::Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309345735
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation. METHODS:B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318819131
更新日期:2019-02-01 00:00:00
abstract::Tumour necrosis factor (TNFalpha) is a cytokine with a wide range of diverse and at times paradoxical effects. These include immunoregulatory, lymphoid organogenesis and pro-inflammatory effects. In recent years, TNFalpha has become a focus of interest more for its inflammatory effects in a number of chronic autoimmun...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu306rr
更新日期:2002-01-01 00:00:00
abstract::We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315572715
更新日期:2015-06-01 00:00:00
abstract::Recent accumulated evidence suggests that prolactin (PRL) is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Our aim was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation with disease activity. PRL plasma levels...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678920361
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320938453
更新日期:2020-09-01 00:00:00
abstract::Intestinal pseudo-obstruction (IpsO) occurs in a small subgroup of patients with systemic lupus erythematosus (SLE), and has been under-recognized. The etiology and mechanisms are unclear. Herein, we report two cases. In case 1, IpsO occurred as the complication in a previously diagnosed SLE patient. In case 2, IpsO w...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311405702
更新日期:2011-10-01 00:00:00
abstract::Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678847407
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will undertake such travel. In this context, the lupus patient presents a great challenge to the rheumatologist. However, the demand for such information by patient...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319888688
更新日期:2019-12-01 00:00:00
abstract::Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients witho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674820
更新日期:2017-04-01 00:00:00