Abstract:
:Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is strongly related to vascular calcification. We determined the association of this biomarker with subclinical atherosclerosis in systemic lupus erythematous (SLE). Methods We measured OPG and markers of subclinical atherosclerosis (coronary artery calcium (CAC), carotid intima-media thickness (cIMT) carotid plaque) in 166 SLE patients (91% female, 64% Caucasian, 31% African American, 5% others, mean age 45 years). Subgroups of patients with different levels of OPG level were compared with respect to average levels of CAC, cIMT, and with respect to presence of carotid plaque. Age was adjusted for using multiple regression. Results OPG was highly correlated with age ( p < 0.0001). Individuals with higher levels of OPG tended to have higher measures of CAC, cIMT, and more carotid plaque. However, after adjustment for age, these associations, while still positive, were no longer statistically significant. Conclusion In our study much of the association observed was due to confounding by age, and after adjusting for age, our findings do not rule out the possibility of a null association.
journal_name
Lupusjournal_title
Lupusauthors
Kiani AN,Aukrust P,Ueland T,Hollan I,Barr E,Magder LS,Petri Mdoi
10.1177/0961203316682101subject
Has Abstractpub_date
2017-07-01 00:00:00pages
865-870issue
8eissn
0961-2033issn
1477-0962pii
0961203316682101journal_volume
26pub_type
杂志文章,随机对照试验相关文献
LUPUS文献大全abstract::We describe a case of active systemic lupus erythematosus (SLE) complicated with a large amount of pericardial effusion with diastolic collapse of right ventricle suggestive of tamponade. Isolates from surgical drainage of pericardial fluid showed Acinetobacter baumannii exhibiting multiple antibiotics resistance. Des...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600513
更新日期:1997-01-01 00:00:00
abstract::The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315624023
更新日期:2016-06-01 00:00:00
abstract::Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318785245
更新日期:2018-09-01 00:00:00
abstract::Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314548248
更新日期:2014-10-01 00:00:00
abstract::Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306073137
更新日期:2007-01-01 00:00:00
abstract::The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309355301
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315580871
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318804891
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531634
更新日期:2014-09-01 00:00:00
abstract::Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312438114
更新日期:2012-06-01 00:00:00
abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646861
更新日期:2016-12-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313504633
更新日期:2013-11-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200605
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500547
更新日期:2013-11-01 00:00:00
abstract::Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318770023
更新日期:2018-09-01 00:00:00
abstract::In this study, we report the case of a Chinese patient with systemic lupus erythematosus (SLE) who developed neutropenia after treatment by olanzapine for the SLE-related psychiatric symptoms. The relationship between agranulocytosis, SLE and olanzapine is still unknown. Fcγ receptor IIIb (FcγRIIIb) is a low-affinity ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311415889
更新日期:2012-01-01 00:00:00
abstract::Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2213oa
更新日期:2005-01-01 00:00:00
abstract::Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2169oa
更新日期:2005-01-01 00:00:00
abstract::Patients with systemic lupus erythematosus (SLE) frequently have gastrointestinal (GI) symptoms. These are usually self-limiting and related to treatment side-effects or concurrent illness. However, abdominal pain may be due to bowel ischaemia which can lead to infarction and perforation. The likelihood of these serio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu433oa
更新日期:2003-01-01 00:00:00
abstract::The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339400300408
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:The heterogeneous spectrum of systemic lupus erythematosus (SLE) often presents with secondary complications such as cardiovascular disease (CVD), infections and neoplasms. Our study assessed whether the presence of SLE independently increases or reduces the disparities, accounting for the already higher risk...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319884646
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN:Newly diagnosed cases of pSLE were ascertained prospectively from October 20...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552118
更新日期:2015-01-01 00:00:00
abstract:Background:Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Tha...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320911091
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203319862610
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To determine if dehydroepiandrosterone (DHEA) is beneficial in severe systemic lupus erythematosus (SLE). METHODS:A double-blinded, placebo-controlled, randomized clinical trial in 21 patients with severe and active SLE, manifestated primarily by nephritis, serositis or hematological abnormalities. In additi...
journal_title:Lupus
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1191/096120399678847588
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570688
更新日期:2015-08-01 00:00:00
abstract::This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1089oa
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). METHODS:We conducted 32 semi-structured interviews with 16 outpatient youth with SLE/MCTD, age 11 to 22 years, and their parents. We qualitatively defined key featur...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646460
更新日期:2016-08-01 00:00:00
abstract::Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317707062
更新日期:2018-01-01 00:00:00