Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study.

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：:Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...

journal_title：Lupus

authors： Kiani AN,Aukrust P,Ueland T,Hollan I,Barr E,Magder LS,Petri M

更新日期：2017-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...

journal_title：Lupus

authors： Abdel-Aty H,Siegle N,Natusch A,Gromnica-Ihle E,Wassmuth R,Dietz R,Schulz-Menger J

更新日期：2008-06-01 00:00:00

abstract：:Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

journal_title：Lupus

authors： Kabelitz D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In a previous study performed 9 ± 3.6 years ago, 74 asymptomatic patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) underwent lung function testing. A significantly low diffusion capacity (DLCO) ranging from 45% to 70% was recorded in 28 of the 74 (37.8%) patients who wer...

journal_title：Lupus

authors： Elalouf O,Fireman E,Levartovsky D,Kaufman I,Rogovski O,Elkayam O,Caspi D,Paran D

更新日期：2015-08-01 00:00:00

abstract：:Objective The lupus impact tracker (LIT) is a 10-item patient reported outcome tool to measure the impact of systemic lupus erythematosus or its treatment on patients' daily lives. Herein, we describe the responsiveness of the LIT and LupusQoL to changes in disease activity, using the systemic lupus erythematosus resp...

journal_title：Lupus

authors： Devilliers H,Bonithon-Kopp C,Jolly M

更新日期：2017-04-01 00:00:00

abstract：:Therapeutic agents currently in use to treat systemic lupus erythematosus (SLE) are predominantly immunosuppressive agents with limited specificities. Multiple groups, including ours, have illustrated that inducing tolerance in SLE animal models ameliorates disease symptoms and increases survival. We examined if oral ...

journal_title：Lupus

authors： Skaggs BJ,Lourenço EV,Hahn BH

更新日期：2011-08-01 00:00:00

abstract：:Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as ...

journal_title：Lupus

authors： Bilginer Y,Düzova A,Topaloğlu R,Batu ED,Boduroğlu K,Güçer Ş,Bodur I,Alanay Y

更新日期：2016-06-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...

journal_title：Lupus

authors： López-Pedrera Ch,Buendía P,Aguirre MA,Velasco F,Cuadrado MJ

更新日期：2006-01-01 00:00:00

abstract：:Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the...

journal_title：Lupus

authors： Farhey Y,Hess EV

更新日期：1997-01-01 00:00:00

abstract：:To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

journal_title：Lupus

authors： Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

更新日期：2008-09-01 00:00:00

abstract：:Valvular replacement was performed in a patient with primary antiphospholipid syndrome and severe mitral insufficiency. The valvular tissue presented thrombotic phenomena and fibrosis with minimum inflammatory component. ...

journal_title：Lupus

authors： Alvarez-Blanco A,Egurbide-Arberas MV,Aguirre-Errasti C

更新日期：1994-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...

journal_title：Lupus

authors： Lau CS,Yin G,Mok MY

更新日期：2006-01-01 00:00:00

abstract：:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...

journal_title：Lupus

authors： Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MA

更新日期：2012-04-01 00:00:00

abstract：:Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...

journal_title：Lupus

authors： Lambrianides A,Giles IP

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...

journal_title：Lupus

authors： Zhang X,Lindwall E,Gauthier C,Lyman J,Spencer N,Alarakhia A,Fraser A,Ing S,Chen M,Webb-Detiege T,Zakem J,Davis W,Choi YS,Quinet R

更新日期：2015-08-01 00:00:00

abstract：:A 24-y-old male who developed necrotic lesions on the lower extremities together with testicular thrombosis necessitating orchiectomy, demonstrated high level IgG anticardiolipin (aCL) associated with acute HIV infection. This is one of the first cases describing a close relationship between viral infection and the cl...

journal_title：Lupus

authors： Leder AN,Flansbaum B,Zandman-Goddard G,Asherson R,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To examine the potential immunologic mechanism and involvement of antiphospholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphospholipid syndrome (APS). METHODS:Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derive...

journal_title：Lupus

authors： Ziporen L,Goldberg I,Arad M,Hojnik M,Ordi-Ros J,Afek A,Blank M,Sandbank Y,Vilardell-Tarres M,de Torres I,Weinberger A,Asherson RA,Kopolovic Y,Shoenfeld Y

更新日期：1996-06-01 00:00:00

abstract：:Autoantibodies to DNA were discovered over 40 years ago following the discovery a few years earlier of the 'LE' cell phenomenon by Hargraves and colleagues in 1948. These investigators noted that, when leucocytes were incubated with serum from lupus patients, changes in the nucleus could be seen together with phagocyt...

journal_title：Lupus

authors： Mageed RA,Zack DJ

更新日期：2002-01-01 00:00:00

abstract：:The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...

journal_title：Lupus

authors： Touma Z,Urowitz MB,Gladman DD

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...

journal_title：Lupus

authors： Nannini C,Crowson CS,Matteson EL,Moder KG

更新日期：2009-04-01 00:00:00

abstract：:In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...

journal_title：Lupus

authors： Vaarala O

更新日期：1998-01-01 00:00:00

abstract：:Proteinuria is a well-known risk factor for the progression of renal dysfunction in chronic kidney disease; however, its importance for estimating the prognosis of lupus nephritis requires verification. Korean adult patients with renal biopsy-diagnosed diffuse proliferative lupus nephritis who had undergone three or m...

journal_title：Lupus

authors： Koo HS,Kim S,Chin HJ

更新日期：2016-01-01 00:00:00

abstract：:We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short...

journal_title：Lupus

authors： Jose A,Cramer AK,Davar K,Gutierrez G

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to investigate the incidence of both non-vertebral and vertebral fracture in female patients with systemic lupus erythematosus (SLE) and to identify risk factors for incident fracture. METHODS:In a five-year prospective study of 127 female Chinese SLE patients with an average a...

journal_title：Lupus

authors： Zhu TY,Griffith JF,Au SK,Tang XL,Kwok AW,Leung PC,Li EK,Tam LS

更新日期：2014-08-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：:We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...

journal_title：Lupus

authors： Castellino G,Govoni M,Lo Monaco A,Montecucco C,Colombo F,Trotta F

更新日期：2004-01-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：:Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...

journal_title：Lupus

authors： Otsa K,Talli S,Harding P,Parsik E,Esko M,Teepere A,Tammaru M

更新日期：2017-09-01 00:00:00