Affinity purified human antiphospholipid antibodies bind normal term placenta.

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：:Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...

journal_title：Lupus

authors： Monticielo OA,Brenol JC,Chies JA,Longo MG,Rucatti GG,Scalco R,Xavier RM

更新日期：2012-01-01 00:00:00

abstract：:We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...

journal_title：Lupus

authors： Menon S,Snaith ML,Isenberg DA

更新日期：1993-06-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：:Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...

journal_title：Lupus

authors： Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AH

更新日期：2008-03-01 00:00:00

abstract：:In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...

journal_title：Lupus

authors： Vaarala O

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...

journal_title：Lupus

authors： Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...

journal_title：Lupus

authors： Gunashekar S,Prakash M,Minz RW,Sharma A,Sharma S,Dhir V

更新日期：2018-11-01 00:00:00

abstract：:This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...

journal_title：Lupus

authors： Jiménez-Balderas FJ,Morales-Polanco MR,Gutierrez L

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVES:To determine the rates of induced abortions in women with systemic lupus erythematosus (SLE) compared to women from the general population and assess disease-related predictors of induced abortion in women with SLE. METHODS:We identified women with SLE (15-45 years) and determined the number of induced abor...

journal_title：Lupus

authors： Venne K,Scott S,Bernatsky S,Vinet E

更新日期：2020-12-15 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...

journal_title：Lupus

authors： Erkeller-Yüsel F,Hulstaart F,Hannet I,Isenberg D,Lydyard P

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a commonly occurring condition related to systemic autoimmune disease. It is characterized histopathologically by a distinct pattern of granulomatous inflammation in the presence or absence of leukocytoclastic vasculitis. The properties of granulo...

journal_title：Lupus

authors： Terai S,Ueda-Hayakawa I,Nguyen CTH,Ly NTM,Yamazaki F,Kambe N,Son Y,Okamoto H

更新日期：2018-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with comple...

journal_title：Lupus

authors： Lo CH,Wei JCC,Tsai CF,Li LC,Huang SW,Su CH

更新日期：2018-09-01 00:00:00

abstract：:Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...

journal_title：Lupus

authors： Salem D,Subang R,Laplante P,Levine JS,Rauch J

更新日期：2014-10-01 00:00:00

abstract：:Valvular replacement was performed in a patient with primary antiphospholipid syndrome and severe mitral insufficiency. The valvular tissue presented thrombotic phenomena and fibrosis with minimum inflammatory component. ...

journal_title：Lupus

authors： Alvarez-Blanco A,Egurbide-Arberas MV,Aguirre-Errasti C

更新日期：1994-10-01 00:00:00

abstract：:We report a woman with systemic lupus erythematosus (SLE) with diffuse proliferative glomerulonephritis and anti-dsDNA antibodies whose serum contained autoantibodies specific for the phosphorylated form of RNA polymerase II (RNAP IIO), Su and ribosomal P antigen, as well as anti-topoisomerase I antibodies, a marker f...

journal_title：Lupus

authors： Stojanov L,Satoh M,Dooley MA,Kuwana M,Jennette JC,Reeves WH

更新日期：1995-08-01 00:00:00

abstract：:Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...

journal_title：Lupus

authors： Kiani AN,Aukrust P,Ueland T,Hollan I,Barr E,Magder LS,Petri M

更新日期：2017-07-01 00:00:00

abstract：:Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. C...

journal_title：Lupus

authors： Nelson JL

更新日期：2002-01-01 00:00:00

abstract：:Numerous drugs have been linked to the induction or exacerbation of systemic cutaneous lupus erythematosus (SCLE). This report presents the third case of the biologic abatacept as an exacerbating medication for SCLE. A 73-year old woman with a remote history of subacute cutaneous lupus and rheumatoid arthritis, well c...

journal_title：Lupus

authors： Figueredo Zamora E,Callen JP,Schadt CR

更新日期：2020-12-22 00:00:00

abstract：:The use of TNF alpha (TNFalpha) inhibitors has made a strong impact on the management of rheumatoid and psoriatic arthritis, ankylosing spondylitis and Crohn disease. Side effects of these agents include the development of autoantibodies and a lupus-like syndrome (drug-related lupus, DRL). Here, a case of a patient wh...

journal_title：Lupus

authors： Kocharla L,Mongey AB

更新日期：2009-02-01 00:00:00

abstract：:Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...

journal_title：Lupus

authors： Durupt S,Puget M,Lega JC,Durieu I,Reynaud Q

更新日期：2017-01-01 00:00:00

abstract：:To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...

journal_title：Lupus

authors： Cavazzana I,Sala R,Bazzani C,Ceribelli A,Zane C,Cattaneo R,Tincani A,Calzavara-Pinton PG,Franceschini F

更新日期：2009-07-01 00:00:00

abstract：:The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...

journal_title：Lupus

authors： Piotrowski P,Lianeri M,Mostowska M,Wudarski M,Chwalinska-Sadowska H,Jagodzinski PP

更新日期：2008-02-01 00:00:00

abstract：:Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). ...

journal_title：Lupus

authors： Pierangeli SS,Harris EN

更新日期：1996-10-01 00:00:00

abstract：:Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...

journal_title：Lupus

authors： Sebastiani GD,Iuliano A,Canofari C,Bracci M

更新日期：2019-03-01 00:00:00

abstract：:With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will undertake such travel. In this context, the lupus patient presents a great challenge to the rheumatologist. However, the demand for such information by patient...

journal_title：Lupus

authors： Oliveira DS,Hillal JPD,Cordova DDP,de Araujo DB

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...

journal_title：Lupus

authors： Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

更新日期：2014-09-01 00:00:00

abstract：:We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....

journal_title：Lupus

authors： Cavazzana I,Ceribelli A,Quinzanini M,Scarsi M,Airò P,Cattaneo R,Franceschini F

更新日期：2008-08-01 00:00:00

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00