The SLICC/ACR damage index: progress report and experience in the field.

abstract：:The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...

journal_title：Lupus

authors： Chung CP,Oeser A,Avalos I,Raggi P,Stein CM

更新日期：2006-01-01 00:00:00

abstract：:Tubulointerstitial injury is found frequently in lupus nephritis. Immune complex deposits can occur in the tubular basement membranes (TBMs), although its significance in lupus nephritis patients remains unclear. This study assessed the clinical and prognostic features of lupus nephritis patients with TBM deposits in ...

journal_title：Lupus

authors： Wang H,Xu J,Zhang X,Ren YL,Cheng M,Guo ZL,Zhang JC,Cheng H,Xing GL,Wang SX,Yu F,Zhao MH

更新日期：2018-04-01 00:00:00

abstract：:Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...

journal_title：Lupus

authors： Chapman J,Rand JH,Brey RL,Levine SR,Blatt I,Khamashta MA,Shoenfeld Y

更新日期：2003-01-01 00:00:00

abstract：:The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). OBJECTIVE:To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the...

journal_title：Lupus

authors： Mosaad YM,Hammad A,Elghzaly AA,Tawhid ZME,Hammad EM,Showma A,Abdelsalam R,Elmoughy A,Fawzy IM,Anber N

更新日期：2018-11-01 00:00:00

abstract：:We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...

journal_title：Lupus

authors： Daïkha-Dahmane F,Bault JP,Molina-Gomes D,Hillion D,Ville Y

更新日期：2005-01-01 00:00:00

abstract：:Leukopenia and anaemia are observed in about a fifth of all patients with systemic lupus erythematosus (SLE) and may be due either to the destruction of blood cells or their decreased production. The former may be humoral or cell-mediated or result from apoptosis of peripheral blood cells. Several observations suggest...

journal_title：Lupus

authors： Tiefenthaler M,Bacher N,Linert H,Mühlmann O,Hofer S,Sepp N,Amberger A,Geisen F,Obermoser G,Konwalinka G

更新日期：2003-01-01 00:00:00

abstract：:This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...

journal_title：Lupus

authors： Dhillon V,Latchman D,Isenberg D

更新日期：1991-11-01 00:00:00

abstract：:The presence of antibodies against the complex of prothrombin and phosphatidylserine (aPS/PT) more significantly correlates with manifestations of antiphospholipid syndrome (APS) and with the presence of lupus anticoagulants (LA) than antibodies against prothrombin bound to oxygenated polystyrene (aPT-A). To investiga...

journal_title：Lupus

authors： Horita T,Ichikawa K,Kataoka H,Yasuda S,Atsumi T,Koike T

更新日期：2007-01-01 00:00:00

abstract：:Objective The objective of this article is to examine the quality, content, and readability of information and resources in the English language and accessible on the internet by pediatric patients with systemic lupus erythematosus (SLE) and their families in North America. Methods Keywords relevant to SLE were genera...

journal_title：Lupus

authors： Cutler C,Peng T,Stinson J,Tucker L,Boneparth A,Klein Gitelman M,Moorthy LN

更新日期：2018-04-01 00:00:00

abstract：:Objectives We analyzed the clinical follow-up results of 88 lupus nephritis patients to find prognostic factors for the development of chronic kidney disease in ethnically homogeneous Korean patients with biopsy-proven lupus nephritis. Methods Sociodemographic, clinical, laboratory, and treatment-related data at the t...

journal_title：Lupus

authors： Park DJ,Kang JH,Lee JW,Lee KE,Kim TJ,Park YW,Lee JS,Choi YD,Lee SS

更新日期：2017-10-01 00:00:00

abstract：:Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...

journal_title：Lupus

authors： Silvestris F,Grinello D,Tucci M,Cafforio P,Dammacco F

更新日期：2003-01-01 00:00:00

abstract：:We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...

journal_title：Lupus

authors： Cicarini WB,Duarte RCF,Ferreira KS,Loures CMG,Consoli RV,Neiva CLS,de Pádua PM,Nunes FFC,Alves LCV,Reis EA,Moreira CC,Guimarães TMPD,de Toledo VPCP,Carvalho MDG

更新日期：2020-02-01 00:00:00

abstract：:The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...

journal_title：Lupus

authors： Al-Mayouf SM,Al Sonbul A

更新日期：2006-01-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...

journal_title：Lupus

authors： Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

更新日期：2013-06-01 00:00:00

abstract：:We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...

journal_title：Lupus

authors： Hojnik M,Gilburd B,Ziporen L,Blank M,Tomer Y,Scheinberg MA,Tincani A,Rozman B,Shoenfeld Y

更新日期：1994-12-01 00:00:00

abstract：:Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...

journal_title：Lupus

authors： Piette JC

更新日期：1996-10-01 00:00:00

abstract：:In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...

journal_title：Lupus

authors： Dinu AR,Merrill JT,Shen C,Antonov IV,Myones BL,Lahita RG

更新日期：1998-01-01 00:00:00

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：:A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...

journal_title：Lupus

authors： Bulla R,Fischetti F,Bossi F,Tedesco F

更新日期：2004-01-01 00:00:00

abstract：:Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...

journal_title：Lupus

authors： Rattazzi M,Faggin E,Bertipaglia B,Pauletto P

更新日期：2005-01-01 00:00:00

abstract：:Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...

journal_title：Lupus

authors： Rahimi H,Maurer K,Song L,Akhter E,Petri M,Sullivan KE

更新日期：2013-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...

journal_title：Lupus

authors： James JA,Kim-Howard XR,Bruner BF,Jonsson MK,McClain MT,Arbuckle MR,Walker C,Dennis GJ,Merrill JT,Harley JB

更新日期：2007-01-01 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...

journal_title：Lupus

authors： Davey R,Bamford J,Emery P

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...

journal_title：Lupus

authors： Jia J,Xie J,Li H,Wei H,Li X,Hu J,Meng D,Zhang Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specifi...

journal_title：Lupus

authors： Tandon A,Anupam K,Kaushal J,Gautam P,Sharma A,Bhatnagar A

更新日期：2020-12-01 00:00:00

abstract：:The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...

journal_title：Lupus

authors： Malik M,Arora P,Sachdeva R,Sharma L,Ramachandran VG,Pal R

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00