GATA3 rs3824662 gene polymorphism as possible risk factor for systemic lupus erythematosus.

abstract：:The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...

journal_title：Lupus

authors： Qian G,Ran X,Zhou CX,Deng DQ,Zhang PL,Guo Y,Luo JH,Zhou XH,Xie H,Cai M

更新日期：2014-12-01 00:00:00

abstract：:The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...

journal_title：Lupus

authors： Pierangeli SS,Harris EN

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS:Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating ...

journal_title：Lupus

authors： Liu G,Wang H,Le J,Lan L,Xu Y,Yang Y,Chen J,Han F

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...

journal_title：Lupus

authors： Zhang X,Lindwall E,Gauthier C,Lyman J,Spencer N,Alarakhia A,Fraser A,Ing S,Chen M,Webb-Detiege T,Zakem J,Davis W,Choi YS,Quinet R

更新日期：2015-08-01 00:00:00

abstract：:In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...

journal_title：Lupus

authors： Alijotas-Reig J

更新日期：2015-09-01 00:00:00

abstract：:Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and...

journal_title：Lupus

authors： Rosenthal E,Cacoub P

更新日期：2015-04-01 00:00:00

abstract：:Twelve systemic lupus erythematosus (SLE) patients with mild to moderate disease activity (SLEDAI of > or = 6 and on prednisolone < 0.5 mg/kg/day) were included in a prospective, randomized, double-blind, placebo-controlled pilot study for 24 weeks. Six were randomized to receive oral leflunomide and six received plac...

journal_title：Lupus

authors： Tam LS,Li EK,Wong CK,Lam CW,Szeto CC

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...

journal_title：Lupus

authors： Dalby ST,Tang X,Daily JA,Sukumaran S,Collins RT,Bolin EH

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:The use of hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE) offers a wide range of benefits. However, there are evidence in favour of cardiotoxicity, including heart conduction disturbances and congestive heart failure. OBJECTIVE:To determine the effects of HCQ in the resting h...

journal_title：Lupus

authors： Cairoli E,Danese N,Teliz M,Bruzzone MJ,Ferreira J,Rebella M,Cayota A

更新日期：2015-10-01 00:00:00

abstract：:The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...

journal_title：Lupus

authors： Sabio JM,Vargas-Hitos JA,Mediavilla JD,Navarrete-Navarrete N,Zamora-Posadas M,Pérez-Vicente S,Hidalgo-Tenorio C,Díaz-Chamorro A,Jáimez L,Jiménez-Alonso J,Grupo Lupus Virgen de las Nieves.

更新日期：2010-04-01 00:00:00

abstract：:Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...

journal_title：Lupus

authors： Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...

journal_title：Lupus

authors： Deji N,Sugimoto T,Fujimoto T,Aoyama M,Takeda N,Sakaguchi M,Uzu T,Kashiwagi A

更新日期：2007-01-01 00:00:00

abstract：:We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of ≥1 : 160, and the ratio of pleural effusion to serum ANA of ≥1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural eff...

journal_title：Lupus

authors： Toworakul C,Kasitanon N,Sukitawut W,Wichinun R,Louthrenoo W

更新日期：2011-10-01 00:00:00

abstract：:Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...

journal_title：Lupus

authors： Anam K,Amare M,Naik S,Szabo KA,Davis TA

更新日期：2009-04-01 00:00:00

abstract：:Choroidal involvement in systemic lupus erythematosus (SLE) occurs infrequently. We report a 45-y-old woman with bilateral chorioretinopathy associated with SLE. Diagnosis was performed using indirect ophthalmoscopy, retinal fluorescein angiography (FA) and green indocianin angiography (ICG). In this patient chorioret...

journal_title：Lupus

authors： Paroli MP,Riso D,Pinca M,Pivetti-Pezzi P

更新日期：2001-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...

journal_title：Lupus

authors： Nannini C,Crowson CS,Matteson EL,Moder KG

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...

journal_title：Lupus

authors： Wu SA,Yeh KW,Lee WI,Yao TC,Kuo ML,Huang B,Huang JL

更新日期：2013-03-01 00:00:00

abstract：:Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...

journal_title：Lupus

authors： Kobayashi S,Yoshida M,Kitahara T,Abe Y,Tsuchida A,Nojima Y

更新日期：2007-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...

journal_title：Lupus

authors： James JA,Kim-Howard XR,Bruner BF,Jonsson MK,McClain MT,Arbuckle MR,Walker C,Dennis GJ,Merrill JT,Harley JB

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Children with systemic lupus erythematosus (SLE) have an increased prevalence of kidney disease compared to their adult counterparts. Our goal was to identify potential clinical and laboratory predictors of renal disease. METHODS:We performed a cohort study of incident and prevalent patients with SLE aged...

journal_title：Lupus

authors： Sule SD,Moodalbail DG,Burnham J,Fivush B,Furth SL

更新日期：2015-07-01 00:00:00

abstract：:We performed a retrospective study of all systemic lupus erythematosus (SLE) pregnancies during a two-year period (2006-2007) to describe the clinical features, maternal and foetal outcomes in our centre. There were 17 pregnancies in 16 women with SLE. Our patients have a mean age of 28.31 years (SD 5.24) and a mean d...

journal_title：Lupus

authors： Teh CL,Wong JS,Ngeh NK,Loh WL

更新日期：2009-03-01 00:00:00

abstract：:Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...

journal_title：Lupus

authors： Karim MY,Ruiz-Irastorza G,Khamashta MA,Hughes GR

更新日期：2001-01-01 00:00:00

abstract：:The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed b...

journal_title：Lupus

authors： Toloza SM,Cole DE,Gladman DD,Ibañez D,Urowitz MB

更新日期：2010-01-01 00:00:00

abstract：:This study assessed the expression of complement receptor 1 (CR1), decay accelerating factor (DAF) and membrane inhibitor of reactive lysis (CD59) on the erythrocytes and glomerulus of diffuse proliferative glomerulonephritis (DPGN) of systemic lupus erythematosus (SLE) patients using flow cytometry and immunofluoresc...

journal_title：Lupus

authors： Arora M,Arora R,Tiwari SC,Das N,Srivastava LM

更新日期：2000-01-01 00:00:00

abstract：:Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...

journal_title：Lupus

authors： Mulliez SM,De Keyser F,Verbist C,Vantilborgh A,Wijns W,Beukinga I,Devreese KM

更新日期：2015-06-01 00:00:00

abstract：:To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

journal_title：Lupus

authors： Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

更新日期：2008-09-01 00:00:00

abstract：:Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...

journal_title：Lupus

authors： Camps MT,Cuadrado MJ,Ocón P,Alonso A,Gutierrez A,Guil M,Grana MI,de Ramón E

更新日期：1995-02-01 00:00:00

abstract：:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...

journal_title：Lupus

authors： Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MA

更新日期：2012-04-01 00:00:00

abstract：:Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...

journal_title：Lupus

authors： Rattazzi M,Faggin E,Bertipaglia B,Pauletto P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...

journal_title：Lupus

authors： Nguyen QD,Uy HS,Akpek EK,Harper SL,Zacks DN,Foster CS

更新日期：2000-01-01 00:00:00