Abstract:
:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have shown that in systemic lupus erythematosus (SLE) the number of circulating Tregs may be decreased during active disease, and that the extent of such decrease may correlate with severity of the disease. Recent data in murine models of lupus have suggested the possibility to target Tregs for the modulation of SLE, and Treg-based intervention has been proposed as a novel therapeutic mean for a better management of the disease. This review provides an update on the role of Tregs in SLE, discussing new findings in relation to possible targeting of Tregs for immune modulation in lupus.
journal_name
Lupusjournal_title
Lupusauthors
La Cava Adoi
10.1177/0961203308090028subject
Has Abstractpub_date
2008-05-01 00:00:00pages
421-5issue
5eissn
0961-2033issn
1477-0962pii
17/5/421journal_volume
17pub_type
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