Abstract:
:'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to be directed against negatively-charged (anionic) phospholipids current evidence suggests that these autoantibodies recognise protein-phospholipid complexes or the proteins themselves. A number of candidate proteins have been investigated with the two most extensively researched being beta 2-glycoprotein I and prothrombin.
journal_name
Lupusjournal_title
Lupusauthors
Kandiah DA,Krilis SAdoi
10.1177/096120339600500212subject
Has Abstractpub_date
1996-04-01 00:00:00pages
153-5issue
2eissn
0961-2033issn
1477-0962journal_volume
5pub_type
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