Abstract:
:Acquired C1q deficiency secondary to anti C1q auto-antibodies may result in the hypocomplementaemic urticarial vasculitis syndrome and may also be seen in active systemic lupus erythematosus. Some patients with acquired C1 inhibitor deficiency are found to have an underlying malignancy, most commonly lymphoma. We report a case of a 40-year-old man presenting with a lupus-like illness with acquired C1q deficiency secondary to a monoclonal paraprotein in the presence of splenic lymphoma with villous lymphocytes. His clinical symptoms correlated with the presence of the paraprotein. Relapse coincided with a rise in the paraprotein and fall in C1q, C3 and C4. There was no improvement in his clinical condition following combination chemotherapy. He remains on oral prednisolone.
journal_name
Lupusjournal_title
Lupusauthors
Gordon MM,Lucie N,Porter Ddoi
10.1177/096120330000900113subject
Has Abstractpub_date
2000-01-01 00:00:00pages
68-71issue
1eissn
0961-2033issn
1477-0962journal_volume
9pub_type
杂志文章相关文献
LUPUS文献大全abstract::Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360541
更新日期:2010-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multiple organ involvement. B-lymphocyte activity plays a pivotal role in the development and course of the disease. A newly developed agent called belimumab has recently been approved to treat active, autoantibody positive SLE as an add-on to st...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313476154
更新日期:2013-04-01 00:00:00
abstract::Progressive multifocal leukoencephalopathy (PML) is a rare, deadly demyelinating disease of the central nervous system, which is caused by a reactivation of the DNA polyomavirus JC and occurs in immunosuppressed individuals. So far, only 25 cases have been described in patients with SLE and none survived without antiv...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089445
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316638933
更新日期:2016-10-01 00:00:00
abstract::The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar flu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086930
更新日期:2008-04-01 00:00:00
abstract::Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345742
更新日期:2010-01-01 00:00:00
abstract::The potential of oral treatment with AVEMAR (AVEMAR), a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301682430203
更新日期:2001-01-01 00:00:00
abstract::Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200607
更新日期:1993-12-01 00:00:00
abstract::In order to ascertain the incidence of monoclonal gammopathy (MG) in systemic lupus erythematosus (SLE), 120 SLE patients were evaluated. Four patients (3.3%), two of whom were under 50 years of age, were found to have a monoclonal immunoglobulin in their serum. Our data agree with the previous literature in demonstra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100410
更新日期:1992-08-01 00:00:00
abstract::In the 9-year period between 1982 and 1991, 137 patients attending a medical clinic of Queen Elizabeth Hospital, Hong Kong, were diagnosed as having systemic lupus erythematosus according to the American Rheumatism Association's criteria for classification. The female-to-male ratio was 16 to 1. Commonly the onset age ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200207
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remain...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313476360
更新日期:2013-04-01 00:00:00
abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570164
更新日期:2015-09-01 00:00:00
abstract::Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600704
更新日期:1997-01-01 00:00:00
abstract::Proteinuria is a well-known risk factor for the progression of renal dysfunction in chronic kidney disease; however, its importance for estimating the prognosis of lupus nephritis requires verification. Korean adult patients with renal biopsy-diagnosed diffuse proliferative lupus nephritis who had undergone three or m...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315595130
更新日期:2016-01-01 00:00:00
abstract::Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314556140
更新日期:2015-04-01 00:00:00
abstract::Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674819
更新日期:2017-06-01 00:00:00
abstract::A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315573853
更新日期:2015-09-01 00:00:00
abstract::Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500408
更新日期:1996-08-01 00:00:00
abstract::Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308099242
更新日期:2009-04-01 00:00:00
abstract::We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089442
更新日期:2008-08-01 00:00:00
abstract::Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313504636
更新日期:2013-12-01 00:00:00
abstract::Sera from healthy individuals, relatives of lupus patients, and lupus patients with active disease and in remission were screened for IgG and IgM antibodies to ssDNA and dsDNA. The serum samples were also separated into IgG and IgM fractions which were screened for DNA reactivity at dilutions equivalent to those used ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500604
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319853357
更新日期:2019-06-01 00:00:00
abstract::We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314563133
更新日期:2015-03-01 00:00:00
abstract::The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600305
更新日期:1997-01-01 00:00:00
abstract::Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation. To o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu321oa
更新日期:2003-01-01 00:00:00
abstract::Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360809
更新日期:2010-04-01 00:00:00
abstract::The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318801520
更新日期:2018-12-01 00:00:00
abstract::Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316662723
更新日期:2017-03-01 00:00:00
abstract::The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI) is an accepted instrument to ascertain damage. It has been shown to vary among different SLE populations. The aim of this study was to assess SDI score, pattern and factors related to damage in Brazilian SL...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu447xx
更新日期:2003-01-01 00:00:00