Abstract:
:Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation. To obtain a deeper understanding of the role of DNA methylation in the induction of SLE, we reviewed the relationship between DNA methylation and SLE based on findings reported in the literature and our own data. Various studies, including ours, have indicated the possible importance of DNA methylation, especially hypomethylation, in the etiology of SLE. These epigenetic studies may give us clues towards elucidation of the pathogenesis of SLE and development of new therapeutic strategies for this disease.
journal_name
Lupusjournal_title
Lupusauthors
Sekigawa I,Okada M,Ogasawara H,Kaneko H,Hishikawa T,Hashimoto Hdoi
10.1191/0961203303lu321oasubject
Has Abstractpub_date
2003-01-01 00:00:00pages
79-85issue
2eissn
0961-2033issn
1477-0962journal_volume
12pub_type
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