Abstract:
:Systemic lupus erythematosus (SLE) is an autoantibody and immune complex mediated disease. However, it is the ensuing inflammatory process that leads to irreversible organ damage. In fact several murine models of SLE suggest that this inflammatory organ damage can be prevented even in the presence of autoantibodies. Given data from experimental models as well as from patients, proinflammatory cytokines including tumour necrosis factor (TNF) alpha apparently play a significant role in the inflammatory process, but may have immunoregulatory functions at the same time. Therefore, anti-TNF alpha therapy may constitute an interesting candidate approach for treating SLE inflammatory organ disease, but potentially at the cost of increased autoantibody formation. Clinical trials will be required to answer whether TNF alpha blockade fulfils this hope with an acceptable safety profile. Interferon (IFN)-gamma, interleukin (IL)-18, IL-6 and possibly IL-1 are increased in SLE and likewise involved in the inflammatory process. Specific therapeutic agents for blocking these cytokines should be available in the near future.
journal_name
Lupusjournal_title
Lupusauthors
Aringer M,Smolen JSdoi
10.1191/0961203303lu1024oasubject
Has Abstractpub_date
2004-01-01 00:00:00pages
344-7issue
5eissn
0961-2033issn
1477-0962journal_volume
13pub_type
杂志文章,评审相关文献
LUPUS文献大全abstract::We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400506
更新日期:1995-10-01 00:00:00
abstract::To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400307
更新日期:1995-06-01 00:00:00
abstract::Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. This r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319835320
更新日期:2019-04-01 00:00:00
abstract::The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314544186
更新日期:2014-12-01 00:00:00
abstract::The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive pae...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330101001107
更新日期:2001-01-01 00:00:00
abstract::The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto Dec...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301678646191
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:For patients with chronic illnesses the global burden of illness is a crucial health measure hitherto neglected in research studies and clinical practice. We tested the application and validity of PRISM (Pictorial Representation of Illness and Self-Measure), a novel visual method for assessing the burden of i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300678828479
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570688
更新日期:2015-08-01 00:00:00
abstract::Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307077560
更新日期:2007-01-01 00:00:00
abstract::Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310382128
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Identifying factors predicting adverse pregnancy outcomes involving systemic lupus erythematosus (SLE) is a research priority. The aims of this study were to investigate (a) the maternal and fetal outcomes of pregnant lupus patients and the factors associated with adverse pregnancy outcomes, and (b) the ef...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320944503
更新日期:2020-10-01 00:00:00
abstract::This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339100100102
更新日期:1991-11-01 00:00:00
abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2037sa
更新日期:2004-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669240
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to clarify the activation of complement pathways in patients with lupus nephritis (LN), and to elucidate the association between these complement activation types and clinical outcomes. METHODS:We enrolled 115 patients with biopsy-proven LN from 2003 to 2016 from the lupus cohort...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320925165
更新日期:2020-07-01 00:00:00
abstract::Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318770023
更新日期:2018-09-01 00:00:00
abstract::We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316657435
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543921
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319861677
更新日期:2019-08-01 00:00:00
abstract::Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500524
更新日期:1996-10-01 00:00:00
abstract::Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313475691
更新日期:2013-03-01 00:00:00
abstract::XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345777
更新日期:2009-12-01 00:00:00
abstract::The pathogenesis and therapy of shrinking lungs syndrome in patients with systemic lupus erythematosus remains controversial. It has been previously reported that corticosteroid treatment can be effective. We report a patient with shrinking lungs syndrome who presented a good response to inhaled beta-agonist therapy. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600413
更新日期:1997-01-01 00:00:00
abstract::We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200309
更新日期:1993-06-01 00:00:00
abstract::Allergic disorders commonly occur in patients with systemic lupus erythematosus (SLE) and allergies to some drugs may occasionally be related to disease flares. We evaluated the prevalence of several types of allergy in 132 patients with SLE and their families and compared the SLE patients with a control group of 66 p...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200311
更新日期:1993-06-01 00:00:00
abstract::SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. Th...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678847876
更新日期:1999-01-01 00:00:00
abstract::The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2276rr
更新日期:2006-01-01 00:00:00
abstract::Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400213
更新日期:1995-04-01 00:00:00
abstract::The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678919958
更新日期:1998-01-01 00:00:00
abstract::Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...
journal_title:Lupus
pub_type: 共识发展会议,杂志文章,评审
doi:10.1191/0961203303lu392oa
更新日期:2003-01-01 00:00:00