Abstract:
:SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. The allele FcgammaRIIA-H131 encodes a receptor with a histidine at the 131 amino acid position; the other allele FcgammaRIIA-R131 encodes an arginine. This polymorphism is believed to determine the affinity of the receptor for hIgG2 in immune complexes. FcgammaRIIA-H131 has a higher capacity for hIgG2 compared to FcgammaRIIA-R131 as measured by in vitro studies of insoluble immune complex clearance. We have investigated the polymorphism for FcgammaRIIA using a novel polymerase chain reaction-allele specific primer (PCR-ASP) method designed specifically to distinguish the two allelic forms. Our studies were based on 175 Chinese and 50 Malays SLE patients as well as 108 and 50 ethnically matched healthy controls for the respective groups. Analysis of the data (chi2 test with Yates correction factors and odds ratios) revealed that there were no significant differences between SLE patients and controls. We have not found evidence of a protective effect conferred by FcgammaRIIA-H131 in the ethnic groups studied.
journal_name
Lupusjournal_title
Lupusauthors
Yap SN,Phipps ME,Manivasagar M,Tan SY,Bosco JJdoi
10.1191/096120399678847876subject
Has Abstractpub_date
1999-01-01 00:00:00pages
305-10issue
4eissn
0961-2033issn
1477-0962journal_volume
8pub_type
杂志文章相关文献
LUPUS文献大全abstract::Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345725
更新日期:2009-11-01 00:00:00
abstract::Despite strongly held opinions, a trustworthy scientific basis for most statements about autoimmunity, autoimmune diseases and assisted reproductive technologies (ART) does not exist. It is not likely that autoimmunity causes infertility, nor that patients with autoimmune diseases are unusually infertile. When careful...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu2000oa
更新日期:2004-01-01 00:00:00
abstract::Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315603146
更新日期:2016-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a highly heterogeneous disorder in which multiple immunologic abnormalities have been described. In this review, we thoroughly analyse the impaired T cell production of, and response to, interleukin-2 (IL-2) characteristic of patients with SLE. Since it was first reported, several...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120398678920028
更新日期:1998-01-01 00:00:00
abstract::A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678919642
更新日期:1998-01-01 00:00:00
abstract::Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307077560
更新日期:2007-01-01 00:00:00
abstract::Data on the clinical and laboratory profiles of 83 children with SLE have been analysed and compared with data on 187 adults with the disease. The clinical features of childhood SLE are similar to those seen in adults, although clinical and laboratory parameters reflect propensity to a more severe form of the disease ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200204
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319828523
更新日期:2019-03-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the virus causing Coronavirus disease 2019 (COVID-19), has had a huge impact on health services with a high mortality associated with complications including pneumonia and acute respiratory distress syndrome. Historical evidence suggests that Lupus patients h...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203320961848
更新日期:2020-11-01 00:00:00
abstract::The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600305
更新日期:1997-01-01 00:00:00
abstract::In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678920262
更新日期:1998-01-01 00:00:00
abstract::Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100311
更新日期:1992-05-01 00:00:00
abstract::The objective of this study was to determine whether anticardiolipin antibodies (ACL) in SLE patients are associated with a specific pattern of lupus nephritis and/or with renal microvascular changes. Patients with SLE, followed prospectively between June 1991-May 1994 at The Wellesley Hospital Lupus Clinic, who under...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500113
更新日期:1996-02-01 00:00:00
abstract::The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2203oa
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318804891
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to evaluate whether the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of proliferative lupus nephritis (LN) have a distinct baseline presentation, short-term response to immunosuppression (IS) and long-term prognosis. METHODS:Ninety-eig...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313514623
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311405374
更新日期:2011-10-01 00:00:00
abstract::The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu483oa
更新日期:2003-01-01 00:00:00
abstract::To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308093458
更新日期:2008-12-01 00:00:00
abstract::Objective The objective of this article is to examine the quality, content, and readability of information and resources in the English language and accessible on the internet by pediatric patients with systemic lupus erythematosus (SLE) and their families in North America. Methods Keywords relevant to SLE were genera...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317746246
更新日期:2018-04-01 00:00:00
abstract::Platelet activation and decrease in platelet count characterize the development of the most feared form of antiphospholipid syndrome (APS), i.e. catastrophic APS (CAPS). We aimed to assess if immuno-affinity purified anti-β2-glycoprotein I (aβ2GPI) antibodies enhance platelet activation inducing a significant flow obs...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319886915
更新日期:2019-12-01 00:00:00
abstract::The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318801520
更新日期:2018-12-01 00:00:00
abstract::An assessment of prevalence for systemic lupus erythematosus (SLE) has been attempted for the population of far north Queensland in Australia. This huge area has a majority Caucasian population living in a tropical environment. Roughly 10% of the population comprises people of Australian Aboriginal or Torres Strait Is...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu381xx
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531842
更新日期:2014-09-01 00:00:00
abstract::Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308097479
更新日期:2009-04-01 00:00:00
abstract::The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2224oa
更新日期:2005-01-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract::Our objective was to investigate whether quality of life in systemic lupus erythematosus (SLE) differs across ethnoracial groups and to identify factors that may explain race-related differences. Self-administered questionnaire data from 335 White, 40 Black, and 30 Asian women with SLE were obtained from a multi-cente...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/096120330000900710
更新日期:2000-01-01 00:00:00
abstract::Allergic disorders commonly occur in patients with systemic lupus erythematosus (SLE) and allergies to some drugs may occasionally be related to disease flares. We evaluated the prevalence of several types of allergy in 132 patients with SLE and their families and compared the SLE patients with a control group of 66 p...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200311
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to examine some solid tumors incidence in patients with systemic lupus erythematosus (SLE) derived from population-based cohort studies by means of meta-analysis. METHODS:Relevant electronic databases were searched for studies characterizing the associated risk of overall malig...
journal_title:Lupus
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0961203313520060
更新日期:2014-03-01 00:00:00