Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus.


:Twelve systemic lupus erythematosus (SLE) patients with mild to moderate disease activity (SLEDAI of > or = 6 and on prednisolone < 0.5 mg/kg/day) were included in a prospective, randomized, double-blind, placebo-controlled pilot study for 24 weeks. Six were randomized to receive oral leflunomide and six received placebo. Primary outcome of this study included the mean change of SLEDAI at 24 weeks. Secondary outcomes included the changes in proteinuria, complement levels, anti ds-DNA binding, and prednisolone dosage. The mean age of the 12 patients was 41+/-9 years, and the mean disease duration was 8.5+/-5.8 years. All were female except one patient. The disease activity of both groups of patients decreased significantly after six months of treatment (14.7+/-6.0 to 3.7+/-2.3 in leflunomide group, P = 0.028, and 9.7+/-3.4 to 5.2+/-4.1 in placebo group, P = 0.027). Reduction in the SLEDAI from baseline to 24 weeks was significantly greater in the leflunomide group than the placebo group (11.0+/-6.1 in the leflunomide group and 4.5+/-2.4 in the placebo group respectively, P = 0.026). Minor adverse events included transient elevation in ALT, hypertension and transient leucopenia. In summary, leflunomide was more effective than placebo in treating SLE patients with mild to moderate disease activity and was safe and well-tolerated.






Tam LS,Li EK,Wong CK,Lam CW,Szeto CC




Has Abstract


2004-01-01 00:00:00














  • Anti-endothelial cell antibodies in systemic autoimmune diseases: prevalence and clinical significance.

    abstract:OBJECTIVE:To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases. METHODS:Clinical and laborat...


    pub_type: 杂志文章


    authors: Navarro M,Cervera R,Font J,Reverter JC,Monteagudo J,Escolar G,López-Soto A,Ordinas A,Ingelmo M

    更新日期:1997-01-01 00:00:00

  • Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice.

    abstract::The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...


    pub_type: 杂志文章


    authors: Hasegawa K,Hayashi T

    更新日期:2003-01-01 00:00:00

  • Systemic lupus erythematosus in Aborigines and Caucasians in central Australia: a comparative study.

    abstract::The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto Dec...


    pub_type: 杂志文章


    authors: Segasothy M,Phillips PA

    更新日期:2001-01-01 00:00:00

  • Sulpha allergy in lupus patients: a clinical perspective.

    abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...


    pub_type: 杂志文章


    authors: Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AH

    更新日期:2008-03-01 00:00:00

  • Prevention of recurrent miscarriage in women with antiphospholipid syndrome: A systematic review and network meta-analysis.

    abstract:OBJECTIVES:To compare and rank currently available pharmacological interventions for the prevention of recurrent miscarriage (RM) in women with antiphospholipid syndrome (APS). METHODS:A search was performed using PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, CNKI, ClinicalTrials....


    pub_type: 杂志文章


    authors: Yang Z,Shen X,Zhou C,Wang M,Liu Y,Zhou L

    更新日期:2021-01-01 00:00:00

  • Therapeutic drug monitoring of mycophenolate mofetil for the treatment of severely active lupus nephritis.

    abstract:BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...


    pub_type: 临床试验,杂志文章


    authors: Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

    更新日期:2013-06-01 00:00:00

  • Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?

    abstract:OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...


    pub_type: 杂志文章


    authors: Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

    更新日期:2014-09-01 00:00:00

  • Massive ovarian haemorrhage complicating oral anticoagulation in the antiphospholipid syndrome: a report of three cases.

    abstract::We report three cases of severe haemorrhagic rupture of luteal ovarian cyst requiring surgical haemostasis in young women treated with long-term oral anticoagulation for antiphospholipid syndrome (APS) who used no contraception. At the time of bleeding, the international normalized ratios were 3.78, 4.24, and 7.11. An...


    pub_type: 杂志文章


    authors: Crétel E,Cacoub P,Huong DL,Gompel A,Amoura Z,Piette JC

    更新日期:1999-01-01 00:00:00

  • Feto-maternal immune interaction at the placental level.

    abstract::A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...


    pub_type: 杂志文章,评审


    authors: Bulla R,Fischetti F,Bossi F,Tedesco F

    更新日期:2004-01-01 00:00:00

  • HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus.

    abstract::The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA m...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Galeazzi M,Sebastiani GD,Tincani A,Piette JC,Allegri F,Morozzi G,Bellisai F,Scorza R,Ferrara GB,Carcassi C,Font J,Passiu G,Smolen J,Papasteriades C,Houssiau F,Nebro AF,Ramon Garrido ED,Jedryka-Goral A,Marcolongo R

    更新日期:2000-01-01 00:00:00

  • T-regulatory cells in systemic lupus erythematosus.

    abstract::Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...


    pub_type: 杂志文章,评审


    authors: La Cava A

    更新日期:2008-05-01 00:00:00

  • The French-Canadian validation of a disease-specific, patient-reported outcome measure for lupus.

    abstract:OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...


    pub_type: 杂志文章


    authors: Bourré-Tessier J,Clarke AE,Kosinski M,Mikolaitis-Preuss RA,Bernatsky S,Block JA,Jolly M

    更新日期:2014-12-01 00:00:00

  • Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies.

    abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...


    pub_type: 杂志文章


    authors: Barutcu A,Aksu F,Ozcelik F,Barutcu CA,Umit GE,Pamuk ON,Altun A

    更新日期:2015-09-01 00:00:00

  • Low C4 as a risk factor for severe neuropsychiatric flare in patients with systemic lupus erythematosus.

    abstract:OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...


    pub_type: 杂志文章


    authors: Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

    更新日期:2020-09-01 00:00:00

  • Infodemiology of systemic lupus erythematous using Google Trends.

    abstract::Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...


    pub_type: 杂志文章


    authors: Radin M,Sciascia S

    更新日期:2017-07-01 00:00:00

  • Preliminary study on the changes of ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age.

    abstract::Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...


    pub_type: 杂志文章


    authors: Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

    更新日期:2018-03-01 00:00:00

  • The illness experience of youth with lupus/mixed connective tissue disease: a mixed methods analysis of patient and parent perspectives.

    abstract:OBJECTIVE:We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). METHODS:We conducted 32 semi-structured interviews with 16 outpatient youth with SLE/MCTD, age 11 to 22 years, and their parents. We qualitatively defined key featur...


    pub_type: 杂志文章


    authors: Knight A,Vickery M,Fiks AG,Barg FK

    更新日期:2016-08-01 00:00:00

  • Hypertension as the presenting feature of the antiphospholipid syndrome.

    abstract::The antiphospholipid or Hughes syndrome is the association between antiphospholipid antibodies (aPL), venous and arterial thromboses and pregnancy morbidity. Antiphospholipid syndrome (APS) commonly coexists with autoimmune diseases usually systemic lupus erythematosus (SLE), when it is known as secondary APS. When pr...


    pub_type: 杂志文章


    authors: Karim MY,Alba P,Tungekar MF,Abbs IC,Khamashta MA,Hughes GR,Hunt BJ

    更新日期:2002-01-01 00:00:00

  • Hypercatabolism of IgG in mice with lupus-like syndrome.

    abstract::The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. After the onset of the disease a c...


    pub_type: 杂志文章


    authors: Zhou J,Pop LM,Ghetie V

    更新日期:2005-01-01 00:00:00

  • From rheumatic fever to Libman-Sacks endocarditis: is there any possible pathogenetic link?

    abstract::The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...


    pub_type: 杂志文章,评审


    authors: Blank M,Aron-Maor A,Shoenfeld Y

    更新日期:2005-01-01 00:00:00

  • Infections in infancy and the presence of antinuclear antibodies in adult life.

    abstract::There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...


    pub_type: 杂志文章


    authors: Edwards CJ,Syddall H,Goswami R,Goswami P,Dennison EM,Cooper C

    更新日期:2006-01-01 00:00:00

  • Acute sideroblastic anemia in active systemic lupus erythematosus.

    abstract::This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...


    pub_type: 杂志文章


    authors: Jiménez-Balderas FJ,Morales-Polanco MR,Gutierrez L

    更新日期:1994-06-01 00:00:00

  • Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

    abstract:OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...


    pub_type: 杂志文章,meta分析


    authors: Lee YH,Bae SC

    更新日期:2016-10-01 00:00:00

  • The SLICC/ACR damage index: progress report and experience in the field.

    abstract::The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...


    pub_type: 杂志文章


    authors: Gladman DD,Urowitz MB

    更新日期:1999-01-01 00:00:00

  • Superior mesenteric artery syndrome and intra-abdominal compartment syndrome in systemic lupus erythematosus.

    abstract::Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...


    pub_type: 杂志文章


    authors: Bedaiwi M,Alkubeyyer MA,Al Arfaj AS

    更新日期:2014-02-01 00:00:00

  • Risk of complications of ultrasound-guided renal biopsy for adult and pediatric patients with systemic lupus erythematosus.

    abstract::Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imagin...


    pub_type: 杂志文章


    authors: Sun YS,Sun IT,Wang HK,Yang AH,Tsai CY,Huang CJ,Huang DF,Lai CC

    更新日期:2018-04-01 00:00:00

  • Antibodies against phospholipids other than cardiolipin: potential roles for both phospholipid and protein.

    abstract::Autoantibodies to phospholipids other than cardiolipin have received less attention, to date, than anti-cardiolipin antibodies. This review focuses on these antibodies and potential roles for both phospholipid and protein in their reactivity. We review data in the literature indicating that antibodies to phosphatidyle...


    pub_type: 杂志文章,评审


    authors: Rauch J,Janoff AS

    更新日期:1996-10-01 00:00:00

  • Thiazolidinediones and inflammation.

    abstract::Thiazolidinediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor gamma increasingly used in the treatment of type 2 diabetes. Both in vitro and in vivo studies provide evidence that TZDs have anti-inflammatory properties. TZDs inhibit macrophage activation and decrease inflammatory cytokin...


    pub_type: 杂志文章,评审


    authors: Consoli A,Devangelio E

    更新日期:2005-01-01 00:00:00

  • Lupus nephritis in Croatian children: clinicopathologic findings and outcome.

    abstract::We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...


    pub_type: 杂志文章


    authors: Batinić D,Milošević D,Čorić M,Topalović-Grković M,Jelušić M,Turudić D

    更新日期:2015-03-01 00:00:00

  • Systemic lupus erythematosus complicating autoimmune pulmonary alveolar proteinosis that was worsened by immunosuppressive therapy.

    abstract::A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. Autoimmune PAP is rarely associated with system...


    pub_type: 杂志文章


    authors: Nagasawa J,Kurasawa K,Maezawa R,Owada T,Hanaoka R,Fukuda T

    更新日期:2013-09-01 00:00:00