Urinary high-mobility group box-1 associates specifically with lupus nephritis class V.

abstract：:Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...

journal_title：Lupus

authors： Otsa K,Talli S,Harding P,Parsik E,Esko M,Teepere A,Tammaru M

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:The heterogeneous spectrum of systemic lupus erythematosus (SLE) often presents with secondary complications such as cardiovascular disease (CVD), infections and neoplasms. Our study assessed whether the presence of SLE independently increases or reduces the disparities, accounting for the already higher risk...

journal_title：Lupus

authors： Falasinnu T,Chaichian Y,Li J,Chung S,Waitzfelder BE,Fortmann SP,Palaniappan L,Simard JF

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine if dehydroepiandrosterone (DHEA) is beneficial in severe systemic lupus erythematosus (SLE). METHODS:A double-blinded, placebo-controlled, randomized clinical trial in 21 patients with severe and active SLE, manifestated primarily by nephritis, serositis or hematological abnormalities. In additi...

journal_title：Lupus

authors： van Vollenhoven RF,Park JL,Genovese MC,West JP,McGuire JL

更新日期：1999-01-01 00:00:00

abstract：:Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...

journal_title：Lupus

authors： Durupt S,Puget M,Lega JC,Durieu I,Reynaud Q

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoantibody and immune complex mediated disease. However, it is the ensuing inflammatory process that leads to irreversible organ damage. In fact several murine models of SLE suggest that this inflammatory organ damage can be prevented even in the presence of autoantibodies. G...

journal_title：Lupus

authors： Aringer M,Smolen JS

更新日期：2004-01-01 00:00:00

abstract：:We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....

journal_title：Lupus

authors： Cavazzana I,Ceribelli A,Quinzanini M,Scarsi M,Airò P,Cattaneo R,Franceschini F

更新日期：2008-08-01 00:00:00

abstract：:Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...

journal_title：Lupus

authors： Lockshin MD

更新日期：1996-10-01 00:00:00

abstract：:We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of ≥1 : 160, and the ratio of pleural effusion to serum ANA of ≥1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural eff...

journal_title：Lupus

authors： Toworakul C,Kasitanon N,Sukitawut W,Wichinun R,Louthrenoo W

更新日期：2011-10-01 00:00:00

abstract：:Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...

journal_title：Lupus

authors： Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

更新日期：2009-05-01 00:00:00

abstract：:The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...

journal_title：Lupus

authors： Ulcova-Gallova Z

更新日期：2012-06-01 00:00:00

abstract：:The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...

journal_title：Lupus

authors： Blank M,Aron-Maor A,Shoenfeld Y

更新日期：2005-01-01 00:00:00

abstract：:Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...

journal_title：Lupus

authors： Salem D,Subang R,Laplante P,Levine JS,Rauch J

更新日期：2014-10-01 00:00:00

abstract：:Objectives Avascular necrosis (AVN) is one of the most common causes of organ damage in patients with systemic lupus erythematosus (SLE) and often causes serious physical disability. The aims of this study were to investigate clinical risk factors associated with symptomatic AVN and to analyze their synergistic effect...

journal_title：Lupus

authors： Kwon HH,Bang SY,Won S,Park Y,Yi JH,Joo YB,Lee HS,Bae SC

更新日期：2018-09-01 00:00:00

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 ...

journal_title：Lupus

authors： Lee YH,Rho YH,Choi SJ,Ji JD,Song GG

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Since enhanced cardiac magnetic resonance imaging (cMRI) signals have been associated with lupus disease activity in humans prior to renal failure and novel, cardiac-focused therapeutic strategies could be investigated with an associated animal model, autoimmune myocarditis was characterized in murine lupus n...

journal_title：Lupus

authors： Young NA,Jablonski K,Schwarz E,Okafor I,Hampton J,Valiente GR,Henry C,Harb P,Barger J,Bratasz A,Kalyanasundaram A,Ardoin SP,Jarjour WN

更新日期：2020-11-01 00:00:00

abstract：:In a 76-week, randomized controlled trial, patients received 100 mg LJP 394 or placebo weekly for 16 weeks followed by three 12-week treatment cycles of 50 mg LJP 394 or placebo weekly each separated by eight-week periods when no therapy was administered. Health-related quality of life (HRQOL) was assessed using SF-36...

journal_title：Lupus

authors： Strand V,Aranow C,Cardiel MH,Alarcón-Segovia D,Furie R,Sherrer Y,Tumlin J,Wallace DJ,Crawford B,LJP 394 Investigator Consortium.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a commonly occurring condition related to systemic autoimmune disease. It is characterized histopathologically by a distinct pattern of granulomatous inflammation in the presence or absence of leukocytoclastic vasculitis. The properties of granulo...

journal_title：Lupus

authors： Terai S,Ueda-Hayakawa I,Nguyen CTH,Ly NTM,Yamazaki F,Kambe N,Son Y,Okamoto H

更新日期：2018-12-01 00:00:00

abstract：:Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the ant...

journal_title：Lupus

authors： Massaro L,Ceccarelli F,Colasanti T,Pendolino M,Perricone C,Cipriano E,Natalucci F,Capalbo G,Lucchetti R,Pecani A,Vomero M,Mancini R,Spinelli FR,Alessandri C,Valesini G,Conti F

更新日期：2018-01-01 00:00:00

abstract：:Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...

journal_title：Lupus

authors： Camps MT,Cuadrado MJ,Ocón P,Alonso A,Gutierrez A,Guil M,Grana MI,de Ramón E

更新日期：1995-02-01 00:00:00

abstract：:Objective Genetic variants in FH (complement factor H) were reported to associate with susceptibility to systemic lupus erythematosus (SLE). This study proposed that the genetic defects of FH in the susceptibility and in the development of lupus nephritis might be different. Methods This study enrolled 334 lupus nephr...

journal_title：Lupus

authors： Tan M,Hao JB,Chu H,Wang FM,Song D,Zhu L,Yu F,Li YZ,Song Y,Zhao MH

更新日期：2017-10-01 00:00:00

abstract：:A 24-y-old male who developed necrotic lesions on the lower extremities together with testicular thrombosis necessitating orchiectomy, demonstrated high level IgG anticardiolipin (aCL) associated with acute HIV infection. This is one of the first cases describing a close relationship between viral infection and the cl...

journal_title：Lupus

authors： Leder AN,Flansbaum B,Zandman-Goddard G,Asherson R,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...

journal_title：Lupus

authors： Ganguly S,Majumder S,Kumar S,Gupta R,Muhammed H,Shobha V,Aggarwal A,Misra R

更新日期：2020-11-01 00:00:00

abstract：:In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...

journal_title：Lupus

authors： Alijotas-Reig J

更新日期：2015-09-01 00:00:00

abstract：:Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically improved over the past two decades using conventional treatment with low molecular weight heparin and low-dose aspirin. However, despite this regimen, 10-15% of antiphospholipid syndrome patients experience pregnancy losses. Several stud...

journal_title：Lupus

authors： Tabacco S,Giannini A,Garufi C,Botta A,Salvi S,Del Sordo G,Benedetti Panici P,Lanzone A,De Carolis S

更新日期：2019-11-01 00:00:00

abstract：:Only recently Bartonella species have been recognized as important human pathogens. Cat scratch disease (CSD), caused by infection with Bartonella henselae, shows a steady increase in the number of cases throughout the world. We report a case of an 18-year-old woman with systemic lupus erythematosus (SLE) who presente...

journal_title：Lupus

authors： Gaubitz M,Herrmann M,Shahin M,Schotte H,Willeke P,Domschke W

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:The objective of this study is to determine whether serum concentrations of B cell activating factor from the tumour necrosis factor family (BAFF) and/or a proliferation-inducing ligand (APRIL) are associated with clinical manifestations of systemic lupus erythematosus (SLE). METHODS:BAFF and APRIL concen...

journal_title：Lupus

authors： Vincent FB,Northcott M,Hoi A,Mackay F,Morand EF

更新日期：2013-08-01 00:00:00

abstract：:Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...

journal_title：Lupus

authors： Rahimi H,Maurer K,Song L,Akhter E,Petri M,Sullivan KE

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. The aim of this paper is to review the...

journal_title：Lupus

authors： Palagini L,Mosca M,Tani C,Gemignani A,Mauri M,Bombardieri S

更新日期：2013-04-01 00:00:00

abstract：:Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...

journal_title：Lupus

authors： Choi MY,Barber MR,Barber CE,Clarke AE,Fritzler MJ

更新日期：2016-07-01 00:00:00