Genetic variants in FH are associated with renal histopathologic subtypes of lupus nephritis: a large cohort study from China.

abstract：:We performed a retrospective study of all systemic lupus erythematosus (SLE) pregnancies during a two-year period (2006-2007) to describe the clinical features, maternal and foetal outcomes in our centre. There were 17 pregnancies in 16 women with SLE. Our patients have a mean age of 28.31 years (SD 5.24) and a mean d...

journal_title：Lupus

authors： Teh CL,Wong JS,Ngeh NK,Loh WL

更新日期：2009-03-01 00:00:00

abstract：:The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding...

journal_title：Lupus

authors： Atsumi T,Khamashta MA,Ames PR,Ichikawa K,Koike T,Hughes GR

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...

journal_title：Lupus

authors： Jesus AA,Liphaus BL,Silva CA,Bando SY,Andrade LE,Coutinho A,Carneiro-Sampaio M

更新日期：2011-10-01 00:00:00

abstract：:Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...

journal_title：Lupus

authors： Petri M

更新日期：2010-04-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：:Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...

journal_title：Lupus

authors： Dassouki T,Benatti FB,Pinto AJ,Roschel H,Lima FR,Augusto K,Pasoto S,Pereira RMR,Gualano B,de Sá Pinto AL

更新日期：2017-06-01 00:00:00

abstract：:Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...

journal_title：Lupus

authors： Khraishi MM,Singh G

更新日期：1996-06-01 00:00:00

abstract：:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...

journal_title：Lupus

authors： La Cava A

更新日期：2008-05-01 00:00:00

abstract：:Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...

journal_title：Lupus

authors： Otsa K,Talli S,Harding P,Parsik E,Esko M,Teepere A,Tammaru M

更新日期：2017-09-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...

journal_title：Lupus

authors： Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

更新日期：2011-10-01 00:00:00

abstract：:Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe infections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Dam...

journal_title：Lupus

authors： Jönsen A,Gullstrand B,Güner N,Bengtsson AA,Nived O,Truedsson L,Sturfelt G

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...

journal_title：Lupus

authors： Barutcu A,Aksu F,Ozcelik F,Barutcu CA,Umit GE,Pamuk ON,Altun A

更新日期：2015-09-01 00:00:00

abstract：:Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...

journal_title：Lupus

authors： Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AH

更新日期：2008-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with comple...

journal_title：Lupus

authors： Lo CH,Wei JCC,Tsai CF,Li LC,Huang SW,Su CH

更新日期：2018-09-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive pae...

journal_title：Lupus

authors： Blanco-Favela F,Quintal MaG,Chavez-Rueda AK,Leaños-Miranda A,Berron-Peres R,Baca-Ruiz V,Lavalle-Montalvo C

更新日期：2001-01-01 00:00:00

abstract：:Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...

journal_title：Lupus

authors： Rattazzi M,Faggin E,Bertipaglia B,Pauletto P

更新日期：2005-01-01 00:00:00

abstract：:Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...

journal_title：Lupus

authors： Boffa MC,Lachassinne E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...

journal_title：Lupus

authors： Dorgham D,Haggag HM,Attia DH

更新日期：2020-08-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：:The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...

journal_title：Lupus

authors： Malik M,Arora P,Sachdeva R,Sharma L,Ramachandran VG,Pal R

更新日期：2016-06-01 00:00:00

abstract：:Sera from healthy individuals, relatives of lupus patients, and lupus patients with active disease and in remission were screened for IgG and IgM antibodies to ssDNA and dsDNA. The serum samples were also separated into IgG and IgM fractions which were screened for DNA reactivity at dilutions equivalent to those used ...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1996-12-01 00:00:00

abstract：:The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...

journal_title：Lupus

authors： Lui SL,Lam MF,Tse KC,Lo WK

更新日期：2002-01-01 00:00:00

abstract：:Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble...

journal_title：Lupus

authors： Cemil BC,Atas H,Canpolat F,Akca Y,Sasmaz R

更新日期：2013-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...

journal_title：Lupus

authors： Pineau CA,Urowitz MB,Fortin PJ,Ibanez D,Gladman DD

更新日期：2004-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a suggested genetic basis. The newly identified human programmed cell death 1 gene could be associated with SLE susceptibility. We aimed to investigate the association between programmed cell death 1 polymorphism (PD1.3G/A (rs11568821) and PD1...

journal_title：Lupus

authors： Abo El-Khair SM,Sameer W,Awadallah N,Shaalan D

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pregnancies in women with systemic lupus erythematosus (SLE) and lupus nephritis are considered high-risk due to high rates of maternal and fetal complications. However, there has not been a formal analysis addressing the issue of maternal deaths in these women. The aim of this study was to pe...

journal_title：Lupus

authors： Ritchie J,Smyth A,Tower C,Helbert M,Venning M,Garovic V

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...

journal_title：Lupus

authors： Fauchais AL,Lambert M,Launay D,Michon-Pasturel U,Queyrel V,Nguyen N,Hebbar M,Hachulla E,Devulder B,Hatron PY

更新日期：2004-01-01 00:00:00

abstract：:The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...

journal_title：Lupus

authors： Al-Mayouf SM,Al Sonbul A

更新日期：2006-01-01 00:00:00