Abstract:
OBJECTIVE:To determine if dehydroepiandrosterone (DHEA) is beneficial in severe systemic lupus erythematosus (SLE). METHODS:A double-blinded, placebo-controlled, randomized clinical trial in 21 patients with severe and active SLE, manifestated primarily by nephritis, serositis or hematological abnormalities. In addition to conventional treatment with corticosteroids +/- immunosuppressives, patients received DHEA 200 mg/d vs. placebo for 6 months, followed by a 6-month open label period. The primary outcome was a prospectively defined responder analysis, based on a quantitatively specified improvement of the principal severe lupus manifestation at 6 months. RESULTS:Nineteen patients were available for evaluation at 6 months. Baseline imbalance between the groups was noted, with the DHEA group having greater disease activity at baseline (P<0.05 by physician's global assessment). Eleven patients were responders: 7/9 patients on DHEA vs. 4/10 patients on placebo (P<0.10). Of the secondary outcomes, mean improvement in SLE disease activity index (SLE-DAI) score was greater in the DHEA group (-10.3+/-3.1 vs. -3.9+/-1.4. P<0.07). Bone mineral density at the lumbo-sacral spine showed significant reduction in the placebo group, but was maintained in the DHEA group. CONCLUSION:DHEA therapy, when added to conventional treatment for severe SLE, may at most have a small added benefit with respect to lupus outcomes, but baseline imbalances in the study population limit the generalizability of the results. DHEA appears to have a protective effect with respect to corticosteroid-induced osteopenia in such patients.
journal_name
Lupusjournal_title
Lupusauthors
van Vollenhoven RF,Park JL,Genovese MC,West JP,McGuire JLdoi
10.1191/096120399678847588subject
Has Abstractpub_date
1999-01-01 00:00:00pages
181-7issue
3eissn
0961-2033issn
1477-0962journal_volume
8pub_type
临床试验,杂志文章,随机对照试验相关文献
LUPUS文献大全abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700209
更新日期:1998-01-01 00:00:00
abstract::This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus er...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312474705
更新日期:2013-04-01 00:00:00
abstract::Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316662721
更新日期:2017-03-01 00:00:00
abstract::The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/096120339600500105
更新日期:1996-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089401
更新日期:2008-06-01 00:00:00
abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320908936
更新日期:2020-04-01 00:00:00
abstract::The objective of this study was to examine factors predictive of a decline to low levels of disease activity in a cohort of systemic lupus erythematosus (SLE) patients. Patients with SLE of Hispanic (from Texas or Puerto Rico), African-American or Caucasian ethnicity from a multiethnic cohort were included. A decline ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2256oa
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320942296
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES:The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METH...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314555172
更新日期:2015-03-01 00:00:00
abstract::Pericardial effusions causing pericardial tamponade are rare in patients with systemic lupus erythematosus (SLE). The goal of this study is to describe in detail the clinical and laboratory characteristics of a group of patients with pericardial effusions and pericardial tamponade secondary to SLE. We retrospectively ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308100659
更新日期:2009-06-01 00:00:00
abstract:Background:Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Tha...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320911091
更新日期:2020-05-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an immune-mediated disease that is responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide (Cy), represent a subset of patients at high risk of early de...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu491oa
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. OBJECTIVES:The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions -986 (G/A), -602 (G/A), ...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319856089
更新日期:2019-07-01 00:00:00
abstract::The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive pae...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330101001107
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Complement activation plays a role in pathogenesis of the antiphospholipid syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 defi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312458839
更新日期:2012-12-01 00:00:00
abstract::Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317692434
更新日期:2017-08-01 00:00:00
abstract::To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084723
更新日期:2007-01-01 00:00:00
abstract::The objective of the study was to analyse the prevalence and clinical significance of hypocomplementemia in a large series of patients diagnosed either with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (APS) and its association with the main clinical, hematological and immunological fea...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1080oa
更新日期:2004-01-01 00:00:00
abstract::Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543922
更新日期:2014-10-01 00:00:00
abstract::Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2193oa
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314567750
更新日期:2015-08-01 00:00:00
abstract::In vitro data showed that immunoglobulin G (IgG) from lupus nephritis (LN) patients could bind to proximal renal tubular epithelial cells (PTEC), but the clinical relevance of such binding remained unclear. Binding of IgG and subclasses to PTEC was measured by cellular ELISA (expressed as OD index) in 189 serial serum...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315598018
更新日期:2016-01-01 00:00:00
abstract::Up to 80% of patients with systemic lupus erythematosus (SLE) are treated with nonsteroidal anti-inflammatory drugs (NSAID) for musculoskeletal symptoms, serositis and headache. This survey reviews the literature on non-selective and selective inhibitors of cyclooxygenases, with an emphasis on the efficacy and safety ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120300678828794
更新日期:2000-01-01 00:00:00
abstract::Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317747721
更新日期:2017-01-01 00:00:00
abstract::A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2010oa
更新日期:2004-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307078579
更新日期:2007-01-01 00:00:00
abstract::We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400609
更新日期:1995-12-01 00:00:00
abstract::High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311399606
更新日期:2011-08-01 00:00:00
abstract::The potential of oral treatment with AVEMAR (AVEMAR), a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301682430203
更新日期:2001-01-01 00:00:00