SLEDAI-2K Responder Index 50 captures 50% improvement in disease activity over 10 years.

abstract：BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...

journal_title：Lupus

authors： Wu MC,Huang JY,Chen HH,Wei JC

更新日期：2020-06-01 00:00:00

abstract：:XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...

journal_title：Lupus

authors： Lin YJ,Wan L,Huang CM,Chen SY,Huang YC,Lai CH,Lin WY,Liu HP,Wu YS,Chen CM,Tsai YH,Tsai CH,Sheu JJ,Tsai FJ

更新日期：2009-12-01 00:00:00

abstract：:In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...

journal_title：Lupus

authors： Alijotas-Reig J

更新日期：2015-09-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...

journal_title：Lupus

authors： Davey R,Bamford J,Emery P

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：:Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...

journal_title：Lupus

authors： Tselios K,Deeb M,Gladman DD,Harvey P,Urowitz MB

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...

journal_title：Lupus

authors： Wang SH,Chang YS,Liu CJ,Lai CC,Chen TJ,Chen WS

更新日期：2014-06-01 00:00:00

abstract：:Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...

journal_title：Lupus

authors： Mulliez SM,De Keyser F,Verbist C,Vantilborgh A,Wijns W,Beukinga I,Devreese KM

更新日期：2015-06-01 00:00:00

abstract：:Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...

journal_title：Lupus

authors： Clowse ME,Magder L,Petri M

更新日期：2005-01-01 00:00:00

abstract：:Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...

journal_title：Lupus

authors： Evans M,Abdou NI

更新日期：1993-12-01 00:00:00

abstract：:Although the importance of the anticardiolipin test in diagnosis of antiphospholipid syndrome (APS) is widely accepted, there remains much misunderstanding about the strengths and weaknesses of this assay. Several disorders result in formation of low levels of the antibody, hence the anticardiolipin test is not specif...

journal_title：Lupus

authors： Harris EN,Pierangeli SS

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

journal_title：Lupus

authors： De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

更新日期：2012-06-01 00:00:00

abstract：:Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement ...

journal_title：Lupus

authors： Amigo MC

更新日期：2014-10-01 00:00:00

abstract：:The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. After the onset of the disease a c...

journal_title：Lupus

authors： Zhou J,Pop LM,Ghetie V

更新日期：2005-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...

journal_title：Lupus

authors： Delfani P,Sturfelt G,Gullstrand B,Carlsson A,Kassandra M,Borrebaeck CA,Bengtsson AA,Wingren C

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...

journal_title：Lupus

authors： Zhang Q,Sun L,Jin L

更新日期：2015-08-01 00:00:00

abstract：:Recent studies have revealed new populations of T/B cells, including central/effector memory, follicular T cells and CXCR3+ or CXCR4+ B cells. In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythem...

journal_title：Lupus

authors： Watanabe T,Suzuki J,Mitsuo A,Nakano S,Tamayama Y,Katagiri A,Amano H,Morimoto S,Tokano Y,Takasaki Y

更新日期：2008-01-01 00:00:00

abstract：:Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...

journal_title：Lupus

authors： Dassouki T,Benatti FB,Pinto AJ,Roschel H,Lima FR,Augusto K,Pasoto S,Pereira RMR,Gualano B,de Sá Pinto AL

更新日期：2017-06-01 00:00:00

abstract：:Nodular or pseudomembranous tracheobronchitis due to infection by Aspergillus species is an uncommon presentation of invasive aspergillosis. Most cases have been described in severely immunocompromised hosts. We describe the case of a 23-year-old woman, with recently diagnosed systemic lupus erythematosus, who develop...

journal_title：Lupus

authors： Angelotti T,Krishna G,Scott J,Berry G,Weinacker A

更新日期：2002-01-01 00:00:00

abstract：:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...

journal_title：Lupus

authors： Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MA

更新日期：2012-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The internati...

journal_title：Lupus

authors： Prabu A,Gordon C

更新日期：2013-10-01 00:00:00

abstract：:In a 76-week, randomized controlled trial, patients received 100 mg LJP 394 or placebo weekly for 16 weeks followed by three 12-week treatment cycles of 50 mg LJP 394 or placebo weekly each separated by eight-week periods when no therapy was administered. Health-related quality of life (HRQOL) was assessed using SF-36...

journal_title：Lupus

authors： Strand V,Aranow C,Cardiel MH,Alarcón-Segovia D,Furie R,Sherrer Y,Tumlin J,Wallace DJ,Crawford B,LJP 394 Investigator Consortium.

更新日期：2003-01-01 00:00:00

abstract：:We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...

journal_title：Lupus

authors： Koh JH,Ko HS,Lee J,Jung SM,Kwok SK,Ju JH,Park SH

更新日期：2015-06-01 00:00:00

abstract：:Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...

journal_title：Lupus

authors： Laplante P,Fuentes R,Salem D,Subang R,Gillis MA,Hachem A,Farhat N,Qureshi ST,Fletcher CA,Roubey RA,Merhi Y,Thorin É,Levine JS,Mackman N,Rauch J

更新日期：2016-02-01 00:00:00

abstract：:Our objective was to investigate whether quality of life in systemic lupus erythematosus (SLE) differs across ethnoracial groups and to identify factors that may explain race-related differences. Self-administered questionnaire data from 335 White, 40 Black, and 30 Asian women with SLE were obtained from a multi-cente...

journal_title：Lupus

authors： Devins GM,Edworthy SM

更新日期：2000-01-01 00:00:00

abstract：:Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...

journal_title：Lupus

authors： Rattazzi M,Faggin E,Bertipaglia B,Pauletto P

更新日期：2005-01-01 00:00:00

abstract：:Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...

journal_title：Lupus

authors： Fraenkel L,Bogardus ST Jr,Wittink DR

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the occurrence of idiopathic intracranial hypertension (IIH) in patients with systemic lupus erythematosus (SLE) and to describe the manifestations, treatments and outcomes in these patients. METHODS:We reviewed the medical records of 1084 patients with SLE followed up from January 1997 to June 2...

journal_title：Lupus

authors： Kim JM,Kwok SK,Ju JH,Kim HY,Park SH

更新日期：2012-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial advice against pregna...

journal_title：Lupus

authors： Schreiber K

更新日期：2016-04-01 00:00:00