Lupus nephritis in Latin American patients: 10-year results from a single medical center in Argentina.

Abstract:

INTRODUCTION:Several studies have shown that Hispanic patients generally experience a worse renal prognosis than non-Hispanic white patients with lupus. To date, there is no report on American College of Rheumatology (ACR) renal response criteria (ACR-RRC) in patients from Latin America. OBJECTIVE:To evaluate treatment response in patients with proliferative and membranous lupus nephritis (LN) according to ACR-RRC. METHODS:A retrospective study (2001-2011) was performed in our hospital and the data collected included clinical information, renal assessment and immunological parameters. Details related to treatment received during induction and maintenance therapy were also recorded. RESULTS:The study included forty-three Latin American patients (37 women) from Argentina. Mean follow-up was 54 months. The regimen used for induction therapy included intravenous cyclophosphamide (IV-CYC) for six months in 36 patients and only seven received mycophenolate mofetil (MMF) given twice daily for a total dose of 2.5 ± 0.5 grams a day. For the maintenance period, six patients continued with quarterly IV-CYC, 20 patients received MMF (1.5 ± 0.5 grams a day) and 17 patients received azathioprine (AZA) 1.5 - 2 mg/kg/day. ACR-RRC observed after induction therapy was complete response in 19%, partial response in 9%, improvement in 42%, unchanged in 14%, and 16% had deterioration despite treatment. ACR-RRC observed after maintenance therapy was complete response in 30%, partial response in 23%, improvement in 19%, unchanged in 16%, and 12% had deterioration. Relapse was observed in 11 patients (25%). Ten out of 11 cases (91%) who relapsed did not achieve a complete response at the end of the induction therapy. CONCLUSION:In Latin American patients from Argentina, only 19% could achieve a complete response after induction therapy and 30% achieved a complete response after maintenance therapy. Failing to obtain a complete response after induction therapy was related to an increased risk of relapse during long-term follow-up in our study.

journal_name

Lupus

journal_title

Lupus

authors

Vinicki JP,Paniego FM,De Rosa G,Dubinsky D,Laborde HA,Marini A,Nasswetter G

doi

10.1177/0961203315600537

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

217-22

issue

2

eissn

0961-2033

issn

1477-0962

pii

0961203315600537

journal_volume

25

pub_type

杂志文章

相关文献

LUPUS文献大全
  • Visceral leishmaniasis complicating a connective tissue disease: three case reports from Italy.

    abstract::We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/0961203304lu518oa

    authors: Castellino G,Govoni M,Lo Monaco A,Montecucco C,Colombo F,Trotta F

    更新日期:2004-01-01 00:00:00

  • GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus.

    abstract:BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203315617842

    authors: Chung CP,Ormseth MJ,Connelly MA,Oeser A,Solus JF,Otvos JD,Raggi P,Stein CM

    更新日期:2016-03-01 00:00:00

  • The long-term clinical outcome of 56 patients with biopsy-proven lupus nephritis followed at a single center.

    abstract::We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/096120339200100207

    authors: Derksen RH,Hené RJ,Kater L

    更新日期:1992-02-01 00:00:00

  • Allergic disorders in systemic lupus erythematosus.

    abstract::Allergic disorders commonly occur in patients with systemic lupus erythematosus (SLE) and allergies to some drugs may occasionally be related to disease flares. We evaluated the prevalence of several types of allergy in 132 patients with SLE and their families and compared the SLE patients with a control group of 66 p...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/096120339300200311

    authors: Sequeira JF,Cesic D,Keser G,Bukelica M,Karanagnostis S,Khamashta MA,Hughes GR

    更新日期:1993-06-01 00:00:00

  • Myocardial tissue characterization in systemic lupus erythematosus: value of a comprehensive cardiovascular magnetic resonance approach.

    abstract::Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203308089401

    authors: Abdel-Aty H,Siegle N,Natusch A,Gromnica-Ihle E,Wassmuth R,Dietz R,Schulz-Menger J

    更新日期:2008-06-01 00:00:00

  • Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice.

    abstract::Therapeutic agents currently in use to treat systemic lupus erythematosus (SLE) are predominantly immunosuppressive agents with limited specificities. Multiple groups, including ours, have illustrated that inducing tolerance in SLE animal models ameliorates disease symptoms and increases survival. We examined if oral ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203311398509

    authors: Skaggs BJ,Lourenço EV,Hahn BH

    更新日期:2011-08-01 00:00:00

  • Entheseal involvement in systemic lupus erythematosus: are we missing something?

    abstract::Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupu...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203316662723

    authors: Di Matteo A,Satulu I,Di Carlo M,Lato V,Filippucci E,Grassi W

    更新日期:2017-03-01 00:00:00

  • Impaired sexual function in women with systemic lupus erythematosus: a cross-sectional study.

    abstract:OBJECTIVE:The objectives of this paper are to compare sexual function and distress in women with systemic lupus erythematosus (SLE) and in healthy controls; to determine the association between disease characteristics, quality of life, psychopathology and sexual function; and to compare sexual function and distress of ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203313500370

    authors: García Morales M,Callejas Rubio JI,Peralta-Ramírez MI,Henares Romero LJ,Ríos Fernández R,Camps García MT,Navarrete Navarrete N,Ortego Centeno N

    更新日期:2013-09-01 00:00:00

  • The national incidence and clinical picture of SLE in children in Australia - a report from the Australian Paediatric Surveillance Unit.

    abstract:OBJECTIVES:The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN:Newly diagnosed cases of pSLE were ascertained prospectively from October 20...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203314552118

    authors: Mackie FE,Kainer G,Adib N,Boros C,Elliott EJ,Fahy R,Munro J,Murray K,Rosenberg A,Wainstein B,Ziegler JB,Singh-Grewal D

    更新日期:2015-01-01 00:00:00

  • Osteoporosis in systemic lupus erythematosus: factors associated with referral for bone mineral density studies, prevalence of osteoporosis and factors associated with reduced bone density.

    abstract::The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/0961203303lu1036oa

    authors: Pineau CA,Urowitz MB,Fortin PJ,Ibanez D,Gladman DD

    更新日期:2004-01-01 00:00:00

  • Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?

    abstract:OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203314531842

    authors: Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

    更新日期:2014-09-01 00:00:00

  • Correlation of asymptomatic hyperuricaemia and serum uric acid levels with arterial stiffness in women with systemic lupus erythematosus without clinically evident atherosclerotic cardiovascular disease.

    abstract::The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203309355301

    authors: Sabio JM,Vargas-Hitos JA,Mediavilla JD,Navarrete-Navarrete N,Zamora-Posadas M,Pérez-Vicente S,Hidalgo-Tenorio C,Díaz-Chamorro A,Jáimez L,Jiménez-Alonso J,Grupo Lupus Virgen de las Nieves.

    更新日期:2010-04-01 00:00:00

  • Prothrombin as cofactor for antiphospholipids.

    abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1177/096120339800700209

    authors: Galli M,Barbui T

    更新日期:1998-01-01 00:00:00

  • Factors associated with increased white matter hyperintense lesion (WMHI) load in patients with systemic lupus erythematosus (SLE).

    abstract::Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203317707062

    authors: Shaharir SS,Osman SS,Md Rani SA,Sakthiswary R,Said MSM

    更新日期:2018-01-01 00:00:00

  • Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production.

    abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203314567750

    authors: Zhang X,Lindwall E,Gauthier C,Lyman J,Spencer N,Alarakhia A,Fraser A,Ing S,Chen M,Webb-Detiege T,Zakem J,Davis W,Choi YS,Quinet R

    更新日期:2015-08-01 00:00:00

  • The African Lupus Genetics Network (ALUGEN) registry: standardized, prospective follow-up studies in African patients with systemic lupus erythematosus.

    abstract:BACKGROUND:The prevalence and severity of systemic lupus erythematosus (SLE) differs between ethnic groups and geographical regions. Although initially reported as rare, there is growing evidence that SLE is prevalent and runs a severe course in Africa. There is a paucity of prospective studies on African SLE patients....

    journal_title:Lupus

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0961203315606984

    authors: Hodkinson B,Mapiye D,Jayne D,Kalla A,Tiffin N,Okpechi I

    更新日期:2016-03-01 00:00:00

  • Time trend and risk factors of avascular bone necrosis in patients with systemic lupus erythematosus.

    abstract::Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203316676384

    authors: Tse SM,Mok CC

    更新日期:2017-06-01 00:00:00

  • Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus.

    abstract::Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203317692434

    authors: Su-Angka N,Khositseth A,Vilaiyuk S,Tangnararatchakit K,Prangwatanagul W

    更新日期:2017-08-01 00:00:00

  • Reflections on the management of reproductive failure in the antiphospholipid syndrome--the clinician's perspective.

    abstract::It is well known that women with systemic lupus erythematosus (SLE) who have antiphospholipid antibodies (aPL) are at increased risk for pregnancy loss. Additionally, other reproductive processes, such as unexplained infertility and implantation failure after in vitro fertilization and embryo transfer may be affected ...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1191/0961203302lu237ra

    authors: Balasch J,Cervera R

    更新日期:2002-01-01 00:00:00

  • Anti-glycan antibodies as biomarkers for diagnosis and prognosis.

    abstract::Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1191/0961203306lu2331oa

    authors: Dotan N,Altstock RT,Schwarz M,Dukler A

    更新日期:2006-01-01 00:00:00

  • Systemic lupus erythematosus. Disease outcome in patients with a disease duration of at least 10 years: second evaluation.

    abstract::Data related to the disease course of patients with systemic lupus erythematosus (SLE) with special attention to the persistence of disease activity in the long term are scarce. At this moment reliable figures are only known about the survival rate as a measure of outcome. The aim of this multicenter study was to desc...

    journal_title:Lupus

    pub_type: 杂志文章,多中心研究

    doi:10.1191/096120301666282314

    authors: Swaak AJ,van den Brink HG,Smeenk RJ,Manger K,Kalden JR,Tosi S,Domljan Z,Rozman B,Logar D,Pokorny G,Kovacs L,Kovacs A,Vlachoyiannopoulos PG,Moutsopoulos HM,Chwalinska-Sadowska H,Kiss E,Cikes N,Anic B,Schneider M,Fisc

    更新日期:2001-01-01 00:00:00

  • Mannose-binding lectin serum levels in patients with systemic lupus erythematosus: association with thrombocytopaenia and seizure.

    abstract::The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203317722846

    authors: Cieslinski JZ,Skare TL,Nisihara R,De Messias-Reason IJ,Utiyama SRR

    更新日期:2018-03-01 00:00:00

  • Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-1) in active lupus.

    abstract::Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/0961203303lu250oa

    authors: Silvestris F,Grinello D,Tucci M,Cafforio P,Dammacco F

    更新日期:2003-01-01 00:00:00

  • Ferritin in the antiphospholipid syndrome and its catastrophic variant (cAPS).

    abstract:BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203313504633

    authors: Agmon-Levin N,Rosário C,Katz BS,Zandman-Goddard G,Meroni P,Cervera R,Stojanovich L,Blank M,Pierangeli S,Praprotnik S,Meis Ed,Seguro LP,Ruffatti A,Pengo V,Tincani A,Doria A,Shoenfeld Y

    更新日期:2013-11-01 00:00:00

  • Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome.

    abstract:OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203312444172

    authors: De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

    更新日期:2012-06-01 00:00:00

  • Antiphospholipid antibodies and myocardial infarction.

    abstract::In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...

    journal_title:Lupus

    pub_type: 杂志文章,评审

    doi:10.1177/096120339800700229

    authors: Vaarala O

    更新日期:1998-01-01 00:00:00

  • Association between HLA class II antigens and primary antiphospholipid syndrome from the south of Spain.

    abstract::Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/096120339500400111

    authors: Camps MT,Cuadrado MJ,Ocón P,Alonso A,Gutierrez A,Guil M,Grana MI,de Ramón E

    更新日期:1995-02-01 00:00:00

  • Frequency of antibodies to the cholesterol transport protein apolipoprotein A1 in patients with SLE.

    abstract::In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1191/096120398678920262

    authors: Dinu AR,Merrill JT,Shen C,Antonov IV,Myones BL,Lahita RG

    更新日期:1998-01-01 00:00:00

  • SLEDAI-2K Responder Index 50 captures 50% improvement in disease activity over 10 years.

    abstract:OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203312454344

    authors: Touma Z,Gladman DD,Ibañez D,Urowitz MB

    更新日期:2012-10-01 00:00:00

  • Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study.

    abstract:BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...

    journal_title:Lupus

    pub_type: 杂志文章

    doi:10.1177/0961203320923393

    authors: Wu MC,Huang JY,Chen HH,Wei JC

    更新日期:2020-06-01 00:00:00