Diagnostic ANCA algorithms in daily clinical practice: evidence, experience, and effectiveness.

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Ident...

journal_title：Lupus

authors： Appenzeller S,Pineau CA,Clarke AE

更新日期：2011-08-01 00:00:00

abstract：:Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...

journal_title：Lupus

authors： Dotan N,Altstock RT,Schwarz M,Dukler A

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Patients with systemic lupus erythematosus (SLE) with B-lymphocyte stimulator (BLyS) levels ≥ 2 ng/mL are at increased risk of flare. A regression analysis was undertaken to identify routine clinical measures that correlate with BLyS ≥ 2 ng/mL. Efficacy and safety of belimumab 10 mg/kg were examined in pat...

journal_title：Lupus

authors： Roth DA,Thompson A,Tang Y,Hammer AE,Molta CT,Gordon D

更新日期：2016-04-01 00:00:00

abstract：:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...

journal_title：Lupus

authors： Hasegawa K,Hayashi T

更新日期：2003-01-01 00:00:00

abstract：:The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...

journal_title：Lupus

authors： Chung CP,Oeser A,Avalos I,Raggi P,Stein CM

更新日期：2006-01-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To determine if dehydroepiandrosterone (DHEA) is beneficial in severe systemic lupus erythematosus (SLE). METHODS:A double-blinded, placebo-controlled, randomized clinical trial in 21 patients with severe and active SLE, manifestated primarily by nephritis, serositis or hematological abnormalities. In additi...

journal_title：Lupus

authors： van Vollenhoven RF,Park JL,Genovese MC,West JP,McGuire JL

更新日期：1999-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) initially found widespread use in the immunoprophylaxis of rejection in organ transplantation. It has subsequently been used in lupus glomerulonephritis, where early studies have shown it to be effective in induction and maintenance therapy. The randomized studies have mostly studied small ...

journal_title：Lupus

authors： Karim MY,Abbs IC

更新日期：2005-01-01 00:00:00

abstract：:We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...

journal_title：Lupus

authors： Daïkha-Dahmane F,Bault JP,Molina-Gomes D,Hillion D,Ville Y

更新日期：2005-01-01 00:00:00

abstract：:The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis- (PM) and dermatomyositis- (DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81...

journal_title：Lupus

authors： Selva-O'Callaghan A,Labrador-Horrillo M,Muñoz-Gall X,Martínez-Gomez X,Majó-Masferrer J,Solans-Laque R,Simeon-Aznar CP,Morell-Brotard F,Vilardell-Tarrés M

更新日期：2005-01-01 00:00:00

abstract：:Eosinophilic gastroenteritis (EGE) is an uncommon disease and has rarely been reported in association with connective tissue diseases as systemic lupus erythematosus. We report a 36-year-old woman who developed recurrent episodes of abdominal pain, nausea, vomiting and melena. Complete blood counts showed elevated eos...

journal_title：Lupus

authors： Jaimes-Hernandez J,Aranda-Peirera P,Melendez-Mercado CI

更新日期：2009-04-01 00:00:00

abstract：:Although osteoporosis has traditionally been considered a disease of women, men also incur substantial bone loss with aging, and elderly men have age-specific hip fracture incidence rates and vertebral fracture prevalence rates that are at least half those in women. Early postmenopausal bone loss (which results in the...

journal_title：Lupus

authors： Khosla S,Melton LJ 3rd,Riggs BL

更新日期：1999-01-01 00:00:00

abstract：:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...

journal_title：Lupus

authors： La Cava A

更新日期：2008-05-01 00:00:00

abstract：:We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short...

journal_title：Lupus

authors： Jose A,Cramer AK,Davar K,Gutierrez G

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...

journal_title：Lupus

authors： Touma Z,Gladman DD,Ibañez D,Urowitz MB

更新日期：2012-10-01 00:00:00

abstract：:Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...

journal_title：Lupus

authors： Sebastiani GD,Iuliano A,Canofari C,Bracci M

更新日期：2019-03-01 00:00:00

abstract：:The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar flu...

journal_title：Lupus

authors： Rojas-Serrano J,Pedroza J,Regalado J,Robledo J,Reyes E,Sifuentes-Osornio J,Flores-Suárez LF

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...

journal_title：Lupus

authors： Nguyen QD,Uy HS,Akpek EK,Harper SL,Zacks DN,Foster CS

更新日期：2000-01-01 00:00:00

abstract：:To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...

journal_title：Lupus

authors： Cavazzana I,Sala R,Bazzani C,Ceribelli A,Zane C,Cattaneo R,Tincani A,Calzavara-Pinton PG,Franceschini F

更新日期：2009-07-01 00:00:00

abstract：:Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythem...

journal_title：Lupus

authors： Khairullah S,Jasmin R,Yahya F,Cheah TE,Ng CT,Sockalingam S

更新日期：2013-08-01 00:00:00

abstract：:Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...

journal_title：Lupus

authors： Kassi E,Vlachoyiannopoulos PG,Kominakis A,Kiaris H,Moutsopoulos HM,Moutsatsou P

更新日期：2005-01-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：:Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...

journal_title：Lupus

authors： Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

更新日期：2009-05-01 00:00:00

abstract：:This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...

journal_title：Lupus

authors： Boffa MC,Aurousseau MH,Lachassinne E,Dauphin H,Fain O,Le Toumelin P,Uzan M,Piette JC,Derenne S,Boinot C,Avcin T,Motta M,Faden D,Tincani A

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...

journal_title：Lupus

authors： Zhang Q,Sun L,Jin L

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...

journal_title：Lupus

authors： Leiss H,Niederreiter B,Bandur T,Schwarzecker B,Blüml S,Steiner G,Ulrich W,Smolen JS,Stummvoll GH

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...

journal_title：Lupus

authors： Park JW,Moon SY,Lee JH,Park JK,Lee DS,Jung KC,Song YW,Lee EB

更新日期：2014-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...

journal_title：Lupus

authors： Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

更新日期：2008-05-01 00:00:00

abstract：:Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...

journal_title：Lupus

authors： Lambrianides A,Giles IP

更新日期：2010-04-01 00:00:00