Abstract:
:The occurrence of ataxic sensory neuronopathy (ASN) is rare in patients with connective tissue diseases (CTDs). ASN has been described in case reports and case series in patients with CTDs, mostly Sjögren's syndrome, and most often occurring during middle or old age. ASN in association with systemic lupus erythematosus (SLE) is extremely rare; there has been only one reported case in the literature. In addition, to our knowledge, adolescent onset of symptoms in CTD-associated ASN has not been reported previously. We report the case of a young woman who presented with ASN, characterized by sensory ataxia, with elevated antinuclear antibodies, leukopenia and anemia; she fulfilled the diagnostic criteria for SLE about 7 years after the onset of sensory ataxia. Our case points out that ASN may be the initial presenting feature of SLE. SLE should be included in the differential diagnosis of ASN, especially in patients of young age.
journal_name
Lupusjournal_title
Lupusauthors
Wang JC,Lin YC,Yang TF,Lin HYdoi
10.1177/0961203311434105subject
Has Abstractpub_date
2012-07-01 00:00:00pages
905-9issue
8eissn
0961-2033issn
1477-0962pii
0961203311434105journal_volume
21pub_type
杂志文章相关文献
LUPUS文献大全abstract::The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1006oa
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remain...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313476360
更新日期:2013-04-01 00:00:00
abstract::Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317692434
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319828523
更新日期:2019-03-01 00:00:00
abstract::The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318801520
更新日期:2018-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308091539
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320923393
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320942296
更新日期:2020-10-01 00:00:00
abstract::We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400609
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314523868
更新日期:2014-06-01 00:00:00
abstract::Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308097479
更新日期:2009-04-01 00:00:00
abstract::In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200404
更新日期:1993-08-01 00:00:00
abstract::A 26-year-old Japanese female presented to us with a 2-year history of multiple arc-shaped erythematous lesions on her scalp and the right side of her forehead. Histopathological examination of two of the lesions showed lobular and septal panniculitis with deposits of IgG in the basement membrane zone. We diagnosed th...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311433917
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315600539
更新日期:2016-01-01 00:00:00
abstract::The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2224oa
更新日期:2005-01-01 00:00:00
abstract::Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308089990
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320938453
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract::Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319826695
更新日期:2019-03-01 00:00:00
abstract::The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto Dec...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301678646191
更新日期:2001-01-01 00:00:00
abstract::Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu1034oa
更新日期:2004-01-01 00:00:00
abstract::Platelet activation and decrease in platelet count characterize the development of the most feared form of antiphospholipid syndrome (APS), i.e. catastrophic APS (CAPS). We aimed to assess if immuno-affinity purified anti-β2-glycoprotein I (aβ2GPI) antibodies enhance platelet activation inducing a significant flow obs...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319886915
更新日期:2019-12-01 00:00:00
abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570164
更新日期:2015-09-01 00:00:00
abstract::The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300674499064
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314567750
更新日期:2015-08-01 00:00:00
abstract::Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313504636
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313504633
更新日期:2013-11-01 00:00:00
abstract::Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314556140
更新日期:2015-04-01 00:00:00
abstract::Vaccines have undoubtedly brought overwhelming benefits to mankind and are considered safe and effective. Nevertheless, they can occasionally stimulate autoantibody production or even a recently defined syndrome known as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is scarce data regarding autoi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311429817
更新日期:2012-02-01 00:00:00