The CD11b-integrin (ITGAM) and systemic lupus erythematosus.

abstract：OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...

journal_title：Lupus

authors： Ntatsaki E,Vassiliou VS,Velo-Garcia A,Salama AD,Isenberg DA

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...

journal_title：Lupus

authors： Ganguly S,Majumder S,Kumar S,Gupta R,Muhammed H,Shobha V,Aggarwal A,Misra R

更新日期：2020-11-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：:Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...

journal_title：Lupus

authors： Monticielo OA,Brenol JC,Chies JA,Longo MG,Rucatti GG,Scalco R,Xavier RM

更新日期：2012-01-01 00:00:00

abstract：:In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...

journal_title：Lupus

authors： Erkeller-Yüsel F,Hulstaart F,Hannet I,Isenberg D,Lydyard P

更新日期：1993-08-01 00:00:00

abstract：:The objective of this study was to determine whether anticardiolipin antibodies (ACL) in SLE patients are associated with a specific pattern of lupus nephritis and/or with renal microvascular changes. Patients with SLE, followed prospectively between June 1991-May 1994 at The Wellesley Hospital Lupus Clinic, who under...

journal_title：Lupus

authors： Abu-Shakra M,Urowitz MB,Gladman DD,Ritchie S

更新日期：1996-02-01 00:00:00

abstract：:The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...

journal_title：Lupus

authors： Chen HY,Pertusi RM,Kirkland JB,Rubin BR,Jacobson EL

更新日期：1996-02-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00

abstract：:Concerns regarding the safety and efficacy of immunization in patients with SLE have persisted for over 60 years, despite the increased risk of infection in these patients. There are many anecdotal case reports of SLE induction or exacerbation following immunization, but overall, these events seem to be very rare. Evi...

journal_title：Lupus

authors： O'Neill SG,Isenberg DA

更新日期：2006-01-01 00:00:00

abstract：:We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...

journal_title：Lupus

authors： Lynch AM,Rutledge JH,Stephens JK,Murphy JR,Marlar RA,Davila GH,Santos ME,Emlen W

更新日期：1995-10-01 00:00:00

abstract：:Renal involvement in systemic lupus erythematosus is a common complication that significantly worsens morbidity and mortality. Although treatment with corticosteroids and cytotoxic drugs may be useful in many cases, morbidity associated with these drugs and the relapsing nature of the disease make it necessary to deve...

journal_title：Lupus

authors： Alperovich G,Rama I,Lloberas N,Franquesa M,Poveda R,Gomà M,Herrero-Fresneda I,Cruzado JM,Bolaños N,Carrera M,Grinyó JM,Torras J

更新日期：2007-01-01 00:00:00

abstract：:'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to...

journal_title：Lupus

authors： Kandiah DA,Krilis SA

更新日期：1996-04-01 00:00:00

abstract：:CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27- naïve and CD27+ memory B cells as well as CD27high plasma cells. Abnormalities in the distribution ofCD27+ B cell subsets are useful in assessing ...

journal_title：Lupus

authors： Dörner T,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...

journal_title：Lupus

authors： Lau CS,Yin G,Mok MY

更新日期：2006-01-01 00:00:00

abstract：:We report a woman with systemic lupus erythematosus (SLE) with diffuse proliferative glomerulonephritis and anti-dsDNA antibodies whose serum contained autoantibodies specific for the phosphorylated form of RNA polymerase II (RNAP IIO), Su and ribosomal P antigen, as well as anti-topoisomerase I antibodies, a marker f...

journal_title：Lupus

authors： Stojanov L,Satoh M,Dooley MA,Kuwana M,Jennette JC,Reeves WH

更新日期：1995-08-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：:There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...

journal_title：Lupus

authors： Edwards CJ,Syddall H,Goswami R,Goswami P,Dennison EM,Cooper C

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...

journal_title：Lupus

authors： Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...

journal_title：Lupus

authors： Dalby ST,Tang X,Daily JA,Sukumaran S,Collins RT,Bolin EH

更新日期：2019-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...

journal_title：Lupus

authors： James JA,Kim-Howard XR,Bruner BF,Jonsson MK,McClain MT,Arbuckle MR,Walker C,Dennis GJ,Merrill JT,Harley JB

更新日期：2007-01-01 00:00:00

abstract：:Choroidal involvement in systemic lupus erythematosus (SLE) occurs infrequently. We report a 45-y-old woman with bilateral chorioretinopathy associated with SLE. Diagnosis was performed using indirect ophthalmoscopy, retinal fluorescein angiography (FA) and green indocianin angiography (ICG). In this patient chorioret...

journal_title：Lupus

authors： Paroli MP,Riso D,Pinca M,Pivetti-Pezzi P

更新日期：2001-01-01 00:00:00

abstract：:Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...

journal_title：Lupus

authors： Kobayashi S,Yoshida M,Kitahara T,Abe Y,Tsuchida A,Nojima Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE:To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometri...

journal_title：Lupus

authors： Everett ST,Wolf R,Contento I,Haiduc V,Richey M,Erkan D

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller-Fisher syndrome, Guillain-Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations ...

journal_title：Lupus

authors： Labrador-Horrillo M,Martinez-Valle F,Gallardo E,Rojas-Garcia R,Ordi-Ros J,Vilardell M

更新日期：2012-05-01 00:00:00

abstract：:We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...

journal_title：Lupus

authors： Kaburaki J,Kuwana M,Yamamoto M,Kawai S,Matsuura E,Ikeda Y

更新日期：1995-12-01 00:00:00

abstract：:Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...

journal_title：Lupus

authors： Lockshin MD

更新日期：1996-10-01 00:00:00

abstract：:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...

journal_title：Lupus

authors： Hasegawa K,Hayashi T

更新日期：2003-01-01 00:00:00

abstract：:Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...

journal_title：Lupus

authors： Shaharir SS,Osman SS,Md Rani SA,Sakthiswary R,Said MSM

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...

journal_title：Lupus

authors： Wang SH,Chang YS,Liu CJ,Lai CC,Chen TJ,Chen WS

更新日期：2014-06-01 00:00:00

abstract：:Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...

journal_title：Lupus

authors： Beresford MW,Cleary AG,Sills JA,Couriel J,Davidson JE

更新日期：2005-01-01 00:00:00