Abstract:
OBJECTIVE:The feed-forward loop of type I interferons (IFNs) production and subsequent immunopathology of systemic lupus erythematosus (SLE) has been hypothesised to be disrupted with inhibition of IFNα or type I IFN receptor subunit 1 (IFNAR). This systematic review and meta-analysis present the treatment efficacy and safety profile of monoclonal antibodies inhibiting IFNα or IFNAR. METHODS:A search was done using Medline, Embase and ClinicalTrials.gov for biologics targeting IFNα or IFNAR in SLE up to 3 Jan 2020. For the meta-analysis, analyses of binary variables were pooled using odds ratio (OR) with the Mantel Haenszel model. RESULTS:Anifrolumab 300 mg (n = 3 studies, 927 patients) was more effective than placebo in achieving SRI(4) (pooled OR = 1.91, CI 1.11-3.28, P = 0.02) and BICLA response (pooled OR = 2.25, CI 1.72-2.95, P < 0.00001). In SLE patients with high type I IFN gene signature, SRI(4) response was not achieved with anifrolumab in 2 studies, 450 patients. Treatment with IFNα and IFNAR inhibitors (n = 7 studies, 1590 patients) increased the risk of herpes zoster infection (pooled OR = 3.72, CI 1.88-7.39, P = 0.0002), upper respiratory tract infections, nasopharyngitis and bronchitis. CONCLUSION:This meta-analysis substantiates IFNAR as a therapeutic target in SLE. Inhibition of type I IFNs predisposes to herpes zoster and other viral infections.
journal_name
Lupusjournal_title
Lupusauthors
Koh JWH,Ng CH,Tay SHdoi
10.1177/0961203320959702subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1845-1853issue
14eissn
0961-2033issn
1477-0962journal_volume
29pub_type
杂志文章相关文献
LUPUS文献大全abstract::Autoantibodies to DNA were discovered over 40 years ago following the discovery a few years earlier of the 'LE' cell phenomenon by Hargraves and colleagues in 1948. These investigators noted that, when leucocytes were incubated with serum from lupus patients, changes in the nucleus could be seen together with phagocyt...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu317oa
更新日期:2002-01-01 00:00:00
abstract::Corrigendum to A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus by C Cutler et al. Published in Lupus (2018) 27, 762-770. DOI: 10.1177/0961203317746246 . The authors wish to highlight the following correction. The subheading in Table 5 shoul...
journal_title:Lupus
pub_type: 杂志文章,已发布勘误
doi:10.1177/0961203318773684
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:For patients with chronic illnesses the global burden of illness is a crucial health measure hitherto neglected in research studies and clinical practice. We tested the application and validity of PRISM (Pictorial Representation of Illness and Self-Measure), a novel visual method for assessing the burden of i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300678828479
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315580871
更新日期:2015-10-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The objective of this study is to determine whether serum concentrations of B cell activating factor from the tumour necrosis factor family (BAFF) and/or a proliferation-inducing ligand (APRIL) are associated with clinical manifestations of systemic lupus erythematosus (SLE). METHODS:BAFF and APRIL concen...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313496302
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES:The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METH...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314555172
更新日期:2015-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203306072311
更新日期:2006-01-01 00:00:00
abstract::We report the experience from the Antiphospholipid Antibodies (aPL) Regional Consortium in northwest Italy, meant to support clinical research and foster collaboration among health professionals regarding the diagnosis and management of antiphospholipid syndrome (APS) patients. This cohort-study (APS Piedmont Cohort) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312446974
更新日期:2012-06-01 00:00:00
abstract::The objective of this study is to determine if digital vasculitis (DV), a clinical manifestation with a high systemic lupus erythematosus disease activity index (SLEDAI) score, is associated with lupus severity. DV and other clinical manifestations defined according to the SLEDAI were evaluated in 168 consecutive pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309106177
更新日期:2009-10-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308089990
更新日期:2008-05-01 00:00:00
abstract::Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318776110
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to assess the role of gender on survival rate and causes of death and organ damage in systemic lupus erythematosus (SLE) patients in China from 2009 to 2015. METHODS:We conducted a multicenter cohort study to analyze the differences in outcome data between male and female SLE p...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319839845
更新日期:2019-04-01 00:00:00
abstract::We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316657435
更新日期:2017-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with comple...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318782425
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313508832
更新日期:2013-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307078579
更新日期:2007-01-01 00:00:00
abstract::Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301677213822
更新日期:2001-01-01 00:00:00
abstract::Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu250oa
更新日期:2003-01-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500504
更新日期:1996-10-01 00:00:00
abstract::We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319899478
更新日期:2020-02-01 00:00:00
abstract::Multiple sources were used to identify 325 systemic lupus erythematosus (SLE) patients within the city of Oslo during 1999-2009 who met ≥ 4 of the American College of Rheumatology (ACR) criteria. The survival, standard mortality rate (SMR), years of potential life loss before 60 years of age (YPLL60) and causes of dea...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314551083
更新日期:2014-12-01 00:00:00
abstract::Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specifi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320959441
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility. METHODS:A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms an...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203319862610
更新日期:2019-09-01 00:00:00
abstract::We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of ≥1 : 160, and the ratio of pleural effusion to serum ANA of ≥1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural eff...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311402531
更新日期:2011-10-01 00:00:00
abstract::The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive pae...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330101001107
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Current non-invasive methods of assessing disease activity in systemic lupus erythematosus (SLE) are of limited sensitivity and specificity. Testing includes acute phase markers, autoantibodies and complement levels. Although measurements of dsDNA antibodies and complement C3/C4 levels are routine, they rema...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319845487
更新日期:2019-05-01 00:00:00
abstract::The potential of oral treatment with AVEMAR (AVEMAR), a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301682430203
更新日期:2001-01-01 00:00:00
abstract::Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In thi...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301680416922
更新日期:2001-01-01 00:00:00