解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Highly sensitized renal transplant candidates present a group at high risk for acute and chronic rejection. The probability of finding compatible donors for these recipients is significantly lower in comparison to those who have low PRA values. As a consequence, these patients spend longer time on the waiting list and...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00371-3
更新日期:2002-05-01 00:00:00
abstract::CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was design...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00361-0
更新日期:2002-04-01 00:00:00
abstract::One hundred sixty-one DRB1*03 positive individuals from each of five U.S. population groups (Caucasoids, African Americans, Asians/Pacific Islanders, Hispanics, and Native Americans) were randomly selected from a database of 82,979 individuals. DRB1*03 alleles were identified by polymerase chain reaction-sequence-spec...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00379-2
更新日期:2002-03-01 00:00:00
abstract::To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00370-6
更新日期:2002-02-01 00:00:00
abstract::TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00361-5
更新日期:2002-01-01 00:00:00
abstract::Nijmegen breakage syndrome (NBS) is a rare chromosomal-instability syndrome associated with defective DNA repair. Approximately 90% of NBS patients are homozygous for a truncating mutation of the NBS1 gene. As development of the immune system relies on recombination, which involves repair of DNA breaks, one might pred...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00345-7
更新日期:2001-12-01 00:00:00
abstract::This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00324-x
更新日期:2001-11-01 00:00:00
abstract::HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...
journal_title:Human immunology
pub_type: 多中心研究
doi:10.1016/s0198-8859(01)00305-6
更新日期:2001-10-01 00:00:00
abstract::Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00287-7
更新日期:2001-09-01 00:00:00
abstract::Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City). Ten blood group sy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00296-8
更新日期:2001-09-01 00:00:00
abstract::Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00276-2
更新日期:2001-08-01 00:00:00
abstract::Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00254-3
更新日期:2001-07-01 00:00:00
abstract::A two stage PCR-SSOP typing procedure, that permitted HLA-B allele assignment, was applied to DNA samples obtained from six diverse populations -Brazilian, Mexican (Series and Mestizos), Cuban (Caucasoid and Mulatto), South African Zulu, Omani, and Singapore Chinese. HLA-B allele frequencies and HLA-A/B two locus hapl...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00247-6
更新日期:2001-06-01 00:00:00
abstract::Human T suppressor cells (Ts), capable of preventing autologous T helper cells (Th) from reacting against xenogeneic pig endothelial cells and pig APC can be generated in vitro. Ts derive from a population of CD3(+)CD8(+)CD28(-) T lymphocytes and specifically recognize the MHC class I antigens of the APC used for in v...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00238-5
更新日期:2001-05-01 00:00:00
abstract::The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00215-4
更新日期:2001-04-01 00:00:00
abstract::The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00254-8
更新日期:2001-03-01 00:00:00
abstract::An interesting class of immune responses is that in which an environmental agent modifies a self-protein. Heparin induced thrombocytopenia (HIT) is associated with an antibody response in which the immunogen is a self-protein, platelet factor 4 (PF4), modified by an external agent, heparin. We tested the hypothesis th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00242-1
更新日期:2001-02-01 00:00:00
abstract::Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00246-9
更新日期:2001-02-01 00:00:00
abstract::In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00233-0
更新日期:2001-01-01 00:00:00
abstract::We have reviewed the literature on the association of HLA class II with rheumatoid arthritis (RA). Strong linkage disequilibrium among DQB1, DQA1 and DRB1 alleles makes it difficult to evaluate the individual contribution of each locus. Nonetheless, there is a strong case for the role of DQB1*03 and *04 combined with ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(00)00185-3
更新日期:2000-12-01 00:00:00
abstract::The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00213-5
更新日期:2000-12-01 00:00:00
abstract::We compared the immunohistochemical reaction patterns of HLA-G-specific antibodies 87G, 4H84, G233, 16G1, and BFL.1 on human placentas under three different preparative conditions and on cryosections of other human tissues. Human and murine cell lines, either naturally expressing or transfected with HLA-G, were analyz...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00207-x
更新日期:2000-11-01 00:00:00
abstract::Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00200-7
更新日期:2000-11-01 00:00:00
abstract::We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00179-8
更新日期:2000-10-01 00:00:00
abstract::One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00151-8
更新日期:2000-09-01 00:00:00
abstract::Previous studies showed that different HLA-A and -B antigens are differentially expressed in cells. Their relative quantities are genetically predetermined and inherited according to Mendelian laws. To investigate mechanisms responsible for this differential expression, a correlation study between the relative quantit...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00142-7
更新日期:2000-08-01 00:00:00
abstract::The purpose of this article is to study the amounts of gamma-aminobutyric acid-transaminase (GABA-t) during immune response in the human thymus. GABA-t was studied by biochemical and histochemical methods in 7 immunostimulated (treated) and 7 non-immunostimulated (untreated) patients (4 young adult, age range: 24-36 y...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00130-0
更新日期:2000-07-01 00:00:00
abstract::T cell mediated immunity is known to play a central role in the host response to control intra-cellular pathogens. This work demonstrates the presence of specific CD4(+) T cells to Leishmania spp. antigens in peripheral mononuclear cells of naïve individuals (normal volunteers from non-endemic regions). The responder ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00119-1
更新日期:2000-06-01 00:00:00
abstract::In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, D...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00115-4
更新日期:2000-06-01 00:00:00
abstract::The Fas-FasL system plays a crucial role in the maintenance of homeostasis in the immune system. To characterize the Fas/FasL system in macaque monkeys that are commonly used as experimental primates, we cloned and sequenced Fas cDNA derived from the cynomolgus monkey. The predicted amino acid sequence consists of 331...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00100-2
更新日期:2000-05-01 00:00:00
abstract::It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00128-7
更新日期:2000-03-01 00:00:00
abstract::In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00126-3
更新日期:2000-03-01 00:00:00
abstract::Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(99)00151-2
更新日期:2000-02-01 00:00:00
abstract::Identification of mycobacterial antigens that are recognized by CD4+ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases. Our studies in this direction have shown that several recombinant mycobacteri...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00137-8
更新日期:2000-02-01 00:00:00
abstract::One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(99)00169-x
更新日期:2000-01-01 00:00:00
abstract::We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00119-6
更新日期:1999-12-01 00:00:00
abstract::The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00090-7
更新日期:1999-11-01 00:00:00
abstract::Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00102-0
更新日期:1999-11-01 00:00:00
abstract::The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00088-9
更新日期:1999-10-01 00:00:00
abstract::The modified mixed leukocyte reaction (MMLR) test consists of the standard MLR (SMLR) test to which interleukin-4 (IL-4) has been added. It is a sensitive procedure capable of detecting alloreactivity not detected by the SMLR. In the present study we applied the MMLR test to unrelated bone marrow transplantation (BMT)...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00065-8
更新日期:1999-09-01 00:00:00