当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children.

Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children.

Abstract：

:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percentage of resting T cells expressed CD28 in neonates and young children compared to adults. CD28 expression was similar on adult and neonatal T cells activated with PMA and ionomycin. However, CD28 was expressed at greater intensity on a higher percentage of neonatal T cells than adult T cells stimulated with CD3. CD152 expression was lower on neonatal T cells than adult T cells stimulated with PMA and ionomycin and undetectable on neonatal T cells stimulated with CD3. In contrast, intracellular CD152 was equivalent in adult and neonatal T cells stimulated with PMA and ionomycin, suggesting trafficking of CD152 to the cell surface may be differentially regulated in neonatal T cells. Since the T cell response is determined by the balance of signals received from CD28 and CD152, high levels of CD28 expression and lower surface expression of CD152 on neonatal T cells may represent specialisation to promote activation of neonatal T cells.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Elliott SR,Macardle PJ,Roberton DM,Zola H

doi

10.1016/s0198-8859(99)00090-7

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

1039-48

issue

11

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(99)00090-7

journal_volume

60

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease.

    abstract：:Celiac disease (CD) follows an autoimmune course in which both genetic and environmental factors contribute to its development. A strong association with HLA class II molecules, predominantly HLA-DQ2, has been reported in most ethnic groups with CD. The aim of this study was to determine if genetic polymorphisms in L-...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.05.001

    authors： Kaur G,Rapthap CC,Kumar S,Bhatnagar S,Bhan MK,Mehra NK

    更新日期：2006-08-01 00:00:00

  • Basophils are inept at promoting human Th17 responses.

    abstract：:Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2014.12.015

    authors： Sharma M,Stephen-Victor E,Poncet P,Kaveri SV,Bayry J

    更新日期：2015-03-01 00:00:00

  • Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.

    abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.12.007

    authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

    更新日期：2018-02-01 00:00:00

  • [C4d]FlowPRA screening--a specific assay for selective detection of complement-activating anti-HLA alloantibodies.

    abstract：:On waiting lists, transplant candidates are routinely screened for potentially harmful complement-fixing alloantibodies using complement-dependent cytotoxicity (CDC) panel-reactive antibody (PRA) testing. We have recently developed a novel cell-independent assay for assessment of complement-activating panel reactivity...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.12.007

    authors： Wahrmann M,Exner M,Haidbauer B,Schillinger M,Regele H,Körmöczi G,Böhmig GA

    更新日期：2005-05-01 00:00:00

  • HLA-DQA2 (DX alpha) polymorphism and insulin dependent diabetes.

    abstract：:A certain HLA-DQA2 locus TaqI fragment, DX alpha"U", has been reported to be associated with insulin-dependent diabetes mellitus (IDDM). Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that th...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90039-r

    authors： Rowe JR,Neme de Gimenez MH,Emler CA,Sheehy MJ

    更新日期：1990-12-01 00:00:00

  • Association between LMP2/LMP7 genetic variability and the metastasis risk of ovarian cancer in Chinese women in Beijing.

    abstract：:LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.12.006

    authors： Song L,Ma N,Han L,Yan H,Yan B,Yuan Z,Cao B

    更新日期：2014-03-01 00:00:00

  • Why do we have the kidney allocation system we have today? A history of the 2014 kidney allocation system.

    abstract：:"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...

    journal_title：Human immunology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.humimm.2016.08.008

    authors： Stegall MD,Stock PG,Andreoni K,Friedewald JJ,Leichtman AB

    更新日期：2017-01-01 00:00:00

  • Interleukin-6 gene variants and the risk of sepsis development in children.

    abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.06.003

    authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

    更新日期：2007-09-01 00:00:00

  • Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.

    abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.03.017

    authors： Idris ZM,Miswan N,Muhi J,Mohd TA,Kun JF,Noordin R

    更新日期：2011-07-01 00:00:00

  • Association between human leukocyte antigen class I and II alleles and hepatitis C virus infection in high-risk hemodialysis patients awaiting kidney transplantation.

    abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.008

    authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

    更新日期：2013-12-01 00:00:00

  • Elevated serum BAFF levels in patients with autoimmune hepatitis.

    abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.03.010

    authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

    更新日期：2007-07-01 00:00:00

  • Genetic susceptibility and anti-human platelet antigen 5b alloimmunization role of HLA class II and TAP genes.

    abstract：:Platelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(96)00019-5

    authors： Semana G,Zazoun T,Alizadeh M,Morel-Kopp MC,Genetet B,Kaplan C

    更新日期：1996-04-01 00:00:00

  • Potential influence of interleukin-1 haplotype IL-1 beta-511*T-IL-1RN*1 in conferring low risk to middle third location of esophageal cancer: a case-control study.

    abstract：:Interleukin (IL)-1 gene polymorphisms affect several inflammatory diseases, including cancer. Therefore, we studied genetic association of biallelic (-511C>T) polymorphism of IL-1 beta and 86-bp VNTR polymorphism of IL-1RN in 159 patients with esophageal cancer (EC) and 194 age- and gender-matched healthy controls. Ge...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.01.012

    authors： Upadhyay R,Jain M,Kumar S,Ghoshal UC,Mittal B

    更新日期：2008-03-01 00:00:00

  • CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.

    abstract：:Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.08.007

    authors： Liu Y,Liang WB,Gao LB,Pan XM,Chen TY,Wang YY,Xue H,Zhang LS,Zhang L

    更新日期：2010-11-01 00:00:00

  • HLA study in Bolivian Quechua Amerindians from Titikaka Lake Area.

    abstract：:Quechua Amerindians established Inca Empire and chose Cuzco as their capital. Their language is closely related to that of Aymara ethnic group and both of them were originated from Titikaka Lake Altiplano area. In the present study we have analyzed Bolivian Quechua HLA profile and found that it has common characters w...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.05.002

    authors： Arnaiz-Villena A,Juarez I,Lopez-Nares A,Crespo-Yuste E,Callado A,Suarez-Trujillo F

    更新日期：2020-07-01 00:00:00

  • A blueprint for electronic utilization of ambiguous molecular HLA typing data in organ allocation systems and virtual crossmatch.

    abstract：:Virtual crossmatch (VXM) compares a transplant candidate's unacceptable antigens to the HLA typing of the donor before an organ offer is accepted and, in selected cases, supplant a prospective physical crossmatch. However, deceased donor typing can be ambiguous, leading to uncertainty in compatibility prediction. We h...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.01.007

    authors： Kaur N,Pinelli D,Kransdorf EP,Pando MJ,Smith G,Murphey CL,Kamoun M,Bray RA,Tambur A,Gragert L

    更新日期：2020-01-01 00:00:00

  • Different HLA antigen associations for the functionally active and inactive products of the complement C4F1 allele.

    abstract：:The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90006-3

    authors： O'Neill GJ,Miniter P,Pollack MS,Dupont B

    更新日期：1980-07-01 00:00:00

  • HLA-G(∗)01:05N null allele in Mayans (Guatemala) and Uros (Titikaka Lake, Peru): evolution and population genetics.

    abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.12.013

    authors： Arnaiz-Villena A,Enriquez-de-Salamanca M,Areces C,Alonso-Rubio J,Abd-El-Fatah-Khalil S,Fernandez-Honrado M,Rey D

    更新日期：2013-04-01 00:00:00

  • Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa.

    abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.01.004

    authors： Grifoni A,Sidney J,Carpenter C,Phillips E,Mallal S,Scriba TJ,Sette A,Lindestam Arlehamn CS

    更新日期：2018-03-01 00:00:00

  • Improving the performance of virtual crossmatch results by correlating with nationally-performed physical crossmatches: Obtaining additional value from proficiency testing activities.

    abstract：PURPOSE:When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.05.009

    authors： Wrenn SM,Marroquin CE,Hain DS,Harm SK,Pineda JA,Hammond PB,Shah DH,Hillyard SE,Fung MK

    更新日期：2018-08-01 00:00:00

  • HLA-DR alpha, -DX alpha, and DR beta III gene association studies in DR3 individuals.

    abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90018-8

    authors： Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

    更新日期：1987-12-01 00:00:00

  • The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells.

    abstract：:The expression pattern of several genes associated with different processes in melanocytes, including melanogenesis, is changed in vitiligo patients. We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), a...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.01.011

    authors： Reimann E,Kingo K,Karelson M,Reemann P,Loite U,Sulakatko H,Keermann M,Raud K,Abram K,Vasar E,Silm H,Kõks S

    更新日期：2012-04-01 00:00:00

  • Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American women.

    abstract：:The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00088-9

    authors： Acton RT,Dasanayake AP,Harrison RA,Li Y,Roseman JM,Go RC,Wiener H,Caufield PW

    更新日期：1999-10-01 00:00:00

  • Identification of sequence variants in the CCL3 chemokine gene family in the HapMap West African reference population.

    abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2014.06.009

    authors： Perry RT,Nyaku MK,Aissani B,Shrestha S

    更新日期：2014-08-01 00:00:00

  • Investigation of juvenile idiopathic arthritis susceptibility loci: results from a Greek population.

    abstract：:The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an autoimmune disease characterized by persistent chronic arthritis, has been proven highly successful so far. Moreover, accumulated evidence indicates that an ethnic heterogeneity...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.06.018

    authors： Dimopoulou DG,Zervou MI,Trachana M,Myrthianou E,Pratsidou-Gertsi P,Kardassis D,Garyfallos A,Goulielmos GN

    更新日期：2013-09-01 00:00:00

  • TCR expression and clonality analysis in peripheral blood and lymph nodes of HIV-infected patients.

    abstract：:We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00205-x

    authors： Mion M,Indraccolo S,Feroli F,Minuzzo S,Masiero S,Zamarchi R,Barelli A,Borri A,Chieco-Bianchi L,Amadori A

    更新日期：1997-10-01 00:00:00

  • Emerging role of donor-specific anti-human leukocyte antigen antibody determination for clinical management after solid organ transplantation.

    abstract：:Preformed and de novo donor-specific HLA antibodies (DSA) have been associated with allograft dysfunction and failure. The application of solid-phase methods have increased the sensitivity and specificity of antibody detection; however the clinical significance of these DSA is under evaluation. In the present study, w...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.06.009

    authors： Zeevi A,Lunz JG 3rd,Shapiro R,Randhawa P,Mazariegos G,Webber S,Girnita A

    更新日期：2009-08-01 00:00:00

  • IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells.

    abstract：:Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate hum...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.06.002

    authors： Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

    更新日期：2018-08-01 00:00:00

  • Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia.

    abstract：:The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2015.10.004

    authors： Prins JR,van der Hoorn MLP,Keijser R,Ris-Stalpers C,van Beelen E,Afink GB,Claas FHJ,van der Post JAM,Scherjon SA

    更新日期：2016-01-01 00:00:00

  • Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase.

    abstract：:The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00213-5

    authors： Demaria S,Bushkin Y

    更新日期：2000-12-01 00:00:00