Abstract:
:The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p<0.05) and HLA-G (p<0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Prins JR,van der Hoorn MLP,Keijser R,Ris-Stalpers C,van Beelen E,Afink GB,Claas FHJ,van der Post JAM,Scherjon SAdoi
10.1016/j.humimm.2015.10.004subject
Has Abstractpub_date
2016-01-01 00:00:00pages
68-70issue
1eissn
0198-8859issn
1879-1166pii
S0198-8859(15)00507-8journal_volume
77pub_type
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