Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.

abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...

journal_title：Human immunology

authors： Snoussi K,Mahfoudh W,Bouaouina N,Ahmed SB,Helal AN,Chouchane L

更新日期：2006-01-01 00:00:00

abstract：:Many factors induce or enhance expression of major histocompatibility complex class I and class II molecules on various cell types. Human T lymphocytes are class II negative in the resting state but show expression of class II molecules following activation. We analyzed the modulating capacity of the lymphokines recom...

journal_title：Human immunology

authors： Diedrichs-Möhring M,Epplen JT,Schendel DJ

更新日期：1991-08-01 00:00:00

abstract：:There are four DRw8 haplotypes with different DQ alleles in Japanese: DRw8-DQw6 (w1), DRw8-DQw4, DRw8-DQw8(w3), and DRw8-DQw7 (w3). We previously reported the nucleotide sequence of DRB1 gene of DRw8-DQw6(w1) and it was named DRB1*08032. The nucleotide sequences of the other DRw8 DRB1 alleles and their correspondence ...

journal_title：Human immunology

authors： Watanabe Y,Matsushita S,Kohsaka T,Kobayashi N,Nose Y,Tokunaga K,Juji T

更新日期：1992-07-01 00:00:00

abstract：:In the present study, we explored the specific requirements for lysis of human activated T cells by CD4+ CTLs. This was achieved by using human CD4+ T cell lines or clones specific for a peptidic fragment of influenza virus as both CTL effectors and target T cells (TTCs). Our results further establish that human activ...

journal_title：Human immunology

authors： Eljaafari A,Dorval I,Zeliszewski D,Le Gac S,Sterkers G

更新日期：1992-09-01 00:00:00

abstract：:We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...

journal_title：Human immunology

authors： Gonzalez-Escribano MF,Rodriguez R,Valenzuela A,Garcia A,Núñez-Roldan A

更新日期：1999-12-01 00:00:00

abstract：:The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...

journal_title：Human immunology

authors： Liwski RS,Greenshields AL,Murphey C,Bray RA,Gebel HM

更新日期：2017-01-01 00:00:00

abstract：:The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

journal_title：Human immunology

authors： Zachary AA,Delaney NL,Lucas DP,Leffell MS

更新日期：2001-03-01 00:00:00

abstract：:To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

journal_title：Human immunology

authors： Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

更新日期：1995-03-01 00:00:00

abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...

journal_title：Human immunology

authors： Kaufman CL,Zeevi A,Kormos RL,Zerbe TR,Keenan RJ,Uretsky BF,Griffith BP,Hardesty RL,Duquesnoy RJ

更新日期：1990-06-01 00:00:00

abstract：:The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...

journal_title：Human immunology

authors： Orgad S,Yang SY,Gazit E,Relias V,Zaizov R,Lyson S,Yunis EJ

更新日期：1985-03-01 00:00:00

abstract：:More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...

journal_title：Human immunology

authors： Dankers MK,Roelen DL,Korfage N,de Lange P,Witvliet M,Sandkuijl L,Doxiadis II,Claas FH

更新日期：2003-06-01 00:00:00

abstract：:Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typ...

journal_title：Human immunology

authors： Torío A,Sánchez-Guerrero I,Muro M,Villar LM,Minguela A,Marín L,Moya-Quiles MR,Montes-Ares O,Pagán J,Alvarez-López MR

更新日期：2003-08-01 00:00:00

abstract：:HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immu...

journal_title：Human immunology

authors： Jacquier A,Dumont C,Carosella ED,Rouas-Freiss N,LeMaoult J

更新日期：2020-04-01 00:00:00

abstract：:The purpose of this article is to study the amounts of gamma-aminobutyric acid-transaminase (GABA-t) during immune response in the human thymus. GABA-t was studied by biochemical and histochemical methods in 7 immunostimulated (treated) and 7 non-immunostimulated (untreated) patients (4 young adult, age range: 24-36 y...

journal_title：Human immunology

authors： Cavallotti D,Artico M,D'Andrea V,Cavallotti C

更新日期：2000-07-01 00:00:00

abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

journal_title：Human immunology

authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

更新日期：2006-04-01 00:00:00

abstract：:The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...

journal_title：Human immunology

authors： Georgel P

更新日期：2016-11-01 00:00:00

abstract：:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...

journal_title：Human immunology

authors： Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JP

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...

journal_title：Human immunology

authors： Mine KL,Tedesco-Silva H,Mourão TB,Campos EF,Salzedas LA,Aguiar B,Felipe CR,Medina-Pestana JO,Gerbase-DeLima M

更新日期：2018-08-01 00:00:00

abstract：:The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an autoimmune disease characterized by persistent chronic arthritis, has been proven highly successful so far. Moreover, accumulated evidence indicates that an ethnic heterogeneity...

journal_title：Human immunology

authors： Dimopoulou DG,Zervou MI,Trachana M,Myrthianou E,Pratsidou-Gertsi P,Kardassis D,Garyfallos A,Goulielmos GN

更新日期：2013-09-01 00:00:00

abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...

journal_title：Human immunology

authors： Chen Q,Yuan S,Sun H,Peng L

更新日期：2019-03-01 00:00:00

abstract：:Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1...

journal_title：Human immunology

authors： Frisullo G,Iorio R,Plantone D,Nociti V,Patanella AK,Marti A,Palermo C,Valentini P,Mariotti P,Batocchi AP

更新日期：2011-08-01 00:00:00

abstract：:Resident macrophages are mainly responsible for the clearance of apoptotic cells from tissue by phagocytosis. Phagocytosis of apoptotic cells is not accompanied by activation of inflammatory mechanisms, unlike what happens when necrotic phenomena occur. We analyzed the effect of phagocytosis of apoptotic bodies on mac...

journal_title：Human immunology

authors： Filaci G,Contini P,Fravega M,Fenoglio D,Azzarone B,Julien-Giron M,Fiocca R,Boggio M,Necchi V,De Lerma Barbaro A,Merlo A,Rizzi M,Ghio M,Setti M,Puppo F,Zanetti M,Indiveri F

更新日期：2003-01-01 00:00:00

abstract：:Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...

journal_title：Human immunology

authors： Matte C,Lacaille J,Zijenah L,Ward B,Roger M

更新日期：2000-11-01 00:00:00

abstract：:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...

journal_title：Human immunology

authors： Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris J

更新日期：2017-01-01 00:00:00

abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haploty...

journal_title：Human immunology

authors： Lara-Riegos J,Barquera R,Castillo-Chávez OD,Medina-Escobedo CE,Hernández-Zaragoza DI,Arrieta-Bolaños E,Clayton S,Ponnandai-Shanmugavel KS,Bravo-Acevedo A,Zúñiga J,Yunis EJ,Bekker-Méndez C,Granados J

更新日期：2020-09-01 00:00:00

abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

journal_title：Human immunology

authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

更新日期：2018-02-01 00:00:00

abstract：:To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...

journal_title：Human immunology

authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Laitinen I,Kotilainen P,Rajamäki A,Nikoskelainen J,Lilius EM

更新日期：2009-04-01 00:00:00

abstract：:Natural killer (NK) cells are key members of innate immunity against tumor and infection. Killer cell immunoglobulin-like receptor (KIR) genes regulates NK cell function, which varies substantially between individuals in the number and type. Specific KIRs are associated with certain diseases. Herein we investigated if...

journal_title：Human immunology

authors： Ashouri E,Dabbaghmanesh MH,Rowhanirad S,Bakhshayeshkaram M,Ranjbar Omrani G,Ghaderi A

更新日期：2012-10-01 00:00:00

abstract：:Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remain...

journal_title：Human immunology

authors： Hefazi M,Hogan WJ,Wakefield LL,Gandhi MJ

更新日期：2018-12-01 00:00:00

abstract：:Little is known about the etiologies of diseases associated with circulating antineutrophil cytoplasm autoantibodies (ANCA), such as primary vasculitides and inflammatory bowel diseases. However, the understanding of immune mechanisms supposedly involved in the pathogenesis of these diseases is still growing. In the p...

journal_title：Human immunology

authors： Reumaux D,Duthilleul P,Roos D

更新日期：2004-01-01 00:00:00